SDHC and RGS4

		SDHC	RGS4
Description		succinate dehydrogenase complex subunit C	regulator of G protein signaling 4
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex II (succinate Dehydrogenase)	Nucleus Cytoplasm Plasma Membrane Protein-containing Complex
	Molecular Function	Protein Binding Electron Transfer Activity Heme Binding Metal Ion Binding	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity Calmodulin Binding Protein Kinase Binding
	Biological Process	Tricarboxylic Acid Cycle Mitochondrial Electron Transport, Succinate To Ubiquinone Aerobic Respiration Proton Motive Force-driven Mitochondrial ATP Synthesis	Response To Amphetamine G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Heart Rate Response To Cocaine Response To Ethanol Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Calcium Ion Transport Negative Regulation Of Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Actin Filament Organization Negative Regulation Of Glycine Import Across Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Dorsal Root Ganglion Development Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Respiratory electron transport Citric acid cycle (TCA cycle) Maturation of TCA enzymes and regulation of TCA cycle	G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events
Drugs		2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol Ubiquinone Q1
Diseases
GWAS		Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Visceral adipose tissue adjusted for BMI ( 22589738)	Daytime nap ( 33568662) Response to fenofibrate (triglyceride levels) ( 27002377) Response to mTOR inhibitor (rapamycin) ( 24009623)
Interacting Genes		6 interacting genes: ARHGDIA DEDD MDM2 RBFOX2 RGS4 XRCC6	23 interacting genes: BYSL CALM1 COPB1 COPB2 DDR2 EGFR ERBB3 GABBR1 GNAI1 GNAI2 GNAO1 GNAQ KCMF1 KRIT1 MPZ OSMR PFDN2 PLCB1 PTAFR RRM1 SDHC UAP1 UBR1
Entrez ID		6391	5999
HPRD ID		03878	03947
Ensembl ID		ENSG00000143252	ENSG00000117152
Uniprot IDs		A0A0S2Z4B7 A0A0S2Z4C9 A0AAQ5BHE7 Q99643	P49798
PDB IDs		8GS8
Enriched GO Terms of Interacting Partners?		Cellular Response To Gamma Radiation Rho GDP-dissociation Inhibitor Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Response To Gamma Radiation DNA End Binding Negative Regulation Of DNA-templated Transcription Response To Ionizing Radiation Ku70:Ku80 Complex Cellular Response To Ionizing Radiation Negative Regulation Of RNA Biosynthetic Process Response To Alkaloid Response To Vitamin B1 Response To Water-immersion Restraint Stress Response To Formaldehyde Cellular Response To Vitamin B1 Response To Cocaine Cellular Response To Actinomycin D Regulation Of Heart Rate Negative Regulation Of Glycine Import Across Plasma Membrane Negative Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Smooth Muscle Cell Proliferation NEDD8 Ligase Activity Response To Actinomycin D Regulation Of Muscle Cell Differentiation Traversing Start Control Point Of Mitotic Cell Cycle Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Cellular Response To Radiation Cellular Hyperosmotic Salinity Response Protein-containing Complex DNA-dependent Protein Kinase Complex Cellular Response To UV-C Dorsal Root Ganglion Development Hyperosmotic Salinity Response Receptor Serine/threonine Kinase Binding Regulation Of Heart Contraction DNA-dependent Protein Kinase-DNA Ligase 4 Complex 5'-deoxyribose-5-phosphate Lyase Activity GTPase Activator Activity Nucleus Nucleolus Cellular Response To X-ray Negative Regulation Of Macromolecule Biosynthetic Process Nuclear Telomere Cap Complex Cellular Response To Salt Stress Double-stranded Telomeric DNA Binding Nonhomologous End Joining Complex Regulation Of Blood Circulation Atrial Septum Development	Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Secretion G Protein-coupled Serotonin Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Binding Positive Regulation Of Mitotic Cell Cycle Phase Transition Adenylate Cyclase Regulator Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Transport Plasma Membrane Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Acetylcholine Receptor Signaling Pathway Inositol Trisphosphate Metabolic Process Postsynaptic Signal Transduction Negative Regulation Of Secretion By Cell Regulation Of G1/S Transition Of Mitotic Cell Cycle Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Regulation Of Cell Cycle G1/S Phase Transition Cell Surface Receptor Signaling Pathway COPI Vesicle Coat Receptor Complex Regulation Of Secretion Regulation Of Peptide Hormone Secretion G Protein-coupled Receptor Binding G Protein Activity Membrane COPI-coated Vesicle Membrane Protein Tyrosine Kinase Activator Activity Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of Cell Cycle Process GABA-ergic Synapse Positive Regulation Of Cell Cycle Process Regulation Of Hormone Secretion Purinergic Nucleotide Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission ERBB2 Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Response To Prostaglandin E Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Inositol Phosphate Metabolic Process Membrane Coat Protein Tyrosine Kinase Activity
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