DEDD and SLC19A2

		DEDD	SLC19A2
Description		death effector domain containing	solute carrier family 19 member 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm	Plasma Membrane Membrane
	Molecular Function	DNA Binding Protein Binding	Protein Binding Folic Acid Transmembrane Transporter Activity Thiamine Transmembrane Transporter Activity Vitamin Transmembrane Transporter Activity
	Biological Process	Developmental Process Involved In Reproduction Apoptotic Process Spermatogenesis Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Protein Catabolic Process Regulation Of Apoptotic Process Decidualization Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I	Spermatogenesis Thiamine Diphosphate Biosynthetic Process Folic Acid Transport Thiamine Transport Pyridoxine Transport Thiamine-containing Compound Metabolic Process Vitamin Transport Transmembrane Transport Thiamine Transmembrane Transport
Pathways			Vitamin B1 (thiamin) metabolism
Drugs
Diseases
GWAS			Plasma factor V levels in venous thrombosis ( 31271701) Venous thromboembolism ( 21980494)
Interacting Genes		24 interacting genes: APLP2 APP BATF2 CASP10 CASP3 CASP8 CFLAR DEDD2 FADD GTF3C1 GTF3C3 HOXD4 IRF9 KRT18 KRT8 MPZ NR1I3 PRRC2C SDHC SHMT1 SLC19A2 SMAD3 UAP1 VPS26A	3 interacting genes: CERS2 DEDD SC5D
Entrez ID		9191	10560
HPRD ID		06022	04897
Ensembl ID		ENSG00000158796	ENSG00000117479
Uniprot IDs		B1AQP5 O75618	A0A024R8Y5 A0A024R928 O60779
PDB IDs			8Z7Z 8Z80
Enriched GO Terms of Interacting Partners?		Ripoptosome CD95 Death-inducing Signaling Complex Death-inducing Signaling Complex Extrinsic Apoptotic Signaling Pathway Death Receptor Binding Apoptotic Signaling Pathway Death Effector Domain Binding Positive Regulation Of Neuron Apoptotic Process Apoptotic Process Programmed Cell Death Cell Death Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cysteine-type Endopeptidase Activity Positive Regulation Of Execution Phase Of Apoptosis Execution Phase Of Apoptosis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Necroptotic Process Regulation Of Programmed Necrotic Cell Death Regulation Of Neuron Apoptotic Process Response To Anesthetic Transcription Factor TFIIIC Complex 5S Class RRNA Transcription By RNA Polymerase III Cysteine-type Peptidase Activity Response To External Biotic Stimulus Epithelial Cell Apoptotic Process Positive Regulation Of Pyroptotic Inflammatory Response TRAIL-activated Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Response To Cobalt Ion Positive Regulation Of Interleukin-1 Beta Production Regulation Of Programmed Cell Death TRNA Transcription By RNA Polymerase III TRNA Transcription RNA Polymerase III General Transcription Initiation Factor Activity Scaffold Protein Binding Positive Regulation Of Interleukin-1 Production Cell Surface Receptor Signaling Pathway Cell Body Positive Regulation Of Macrophage Differentiation Hepatocyte Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction DNA Binding Transition Metal Ion Binding Platelet Alpha Granule Negative Regulation Of Necroptotic Process Regulation Of Interleukin-1 Beta Production Myeloid Cell Differentiation	Cholesterol Biosynthetic Process Via Lathosterol Cholesterol Biosynthetic Process Via Desmosterol C-5 Sterol Desaturase Activity Delta7-sterol 5(6)-desaturase Activity Negative Regulation Of Schwann Cell Proliferation Involved In Axon Regeneration Negative Regulation Of Schwann Cell Migration Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Sphingosine N-acyltransferase Activity Negative Regulation Of Glial Cell Migration Negative Regulation Of Schwann Cell Proliferation N-acyltransferase Activity Negative Regulation Of Transcription By RNA Polymerase I Negative Regulation Of Ferroptosis Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Negative Regulation Of Axon Regeneration Negative Regulation Of Neuron Projection Regeneration Regulation Of Ferroptosis Lipid Biosynthetic Process Negative Regulation Of Glial Cell Proliferation Regulation Of Glial Cell Migration Response To Immobilization Stress Decidualization Regulation Of Axon Regeneration Regulation Of Neuron Projection Regeneration Cholesterol Biosynthetic Process Sterol Biosynthetic Process Regulation Of Transcription By RNA Polymerase I Regulation Of Glial Cell Proliferation Negative Regulation Of Gliogenesis Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Ceramide Biosynthetic Process Endoplasmic Reticulum Membrane Lipid Metabolic Process
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