RGS4 and UAP1

		RGS4	UAP1
Description		regulator of G protein signaling 4	UDP-N-acetylglucosamine pyrophosphorylase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Protein-containing Complex	Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity Calmodulin Binding Protein Kinase Binding	UDP-N-acetylglucosamine Diphosphorylase Activity Transferase Activity Transferase Activity, Transferring Phosphorus-containing Groups Nucleotidyltransferase Activity Identical Protein Binding UDP-N-acetylgalactosamine Diphosphorylase Activity Uridylyltransferase Activity Protein Serine Pyrophosphorylase Activity
	Biological Process	Response To Amphetamine G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Heart Rate Response To Cocaine Response To Ethanol Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Calcium Ion Transport Negative Regulation Of Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Actin Filament Organization Negative Regulation Of Glycine Import Across Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Dorsal Root Ganglion Development Positive Regulation Of Excitatory Postsynaptic Potential	Immune System Process UDP-N-acetylglucosamine Biosynthetic Process Positive Regulation Of Type I Interferon Production Innate Immune Response Antiviral Innate Immune Response
Pathways		G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events	Synthesis of UDP-N-acetyl-glucosamine
Drugs			Uridine-Diphosphate-N-Acetylgalactosamine Uridine-Diphosphate-N-Acetylglucosamine
Diseases
GWAS		Daytime nap ( 33568662) Response to fenofibrate (triglyceride levels) ( 27002377) Response to mTOR inhibitor (rapamycin) ( 24009623)
Interacting Genes		23 interacting genes: BYSL CALM1 COPB1 COPB2 DDR2 EGFR ERBB3 GABBR1 GNAI1 GNAI2 GNAO1 GNAQ KCMF1 KRIT1 MPZ OSMR PFDN2 PLCB1 PTAFR RRM1 SDHC UAP1 UBR1	3 interacting genes: DEDD FBXL17 RGS4
Entrez ID		5999	6675
HPRD ID		03947	04178
Ensembl ID		ENSG00000117152	ENSG00000117143
Uniprot IDs		P49798	A0A140VKC0 Q16222
PDB IDs			1JV1 1JV3 1JVD 1JVG 6Z2F 8QH2
Enriched GO Terms of Interacting Partners?		Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Secretion G Protein-coupled Serotonin Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Binding Positive Regulation Of Mitotic Cell Cycle Phase Transition Adenylate Cyclase Regulator Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Transport Plasma Membrane Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Acetylcholine Receptor Signaling Pathway Inositol Trisphosphate Metabolic Process Postsynaptic Signal Transduction Negative Regulation Of Secretion By Cell Regulation Of G1/S Transition Of Mitotic Cell Cycle Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Regulation Of Cell Cycle G1/S Phase Transition Cell Surface Receptor Signaling Pathway COPI Vesicle Coat Receptor Complex Regulation Of Secretion Regulation Of Peptide Hormone Secretion G Protein-coupled Receptor Binding G Protein Activity Membrane COPI-coated Vesicle Membrane Protein Tyrosine Kinase Activator Activity Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of Cell Cycle Process GABA-ergic Synapse Positive Regulation Of Cell Cycle Process Regulation Of Hormone Secretion Purinergic Nucleotide Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission ERBB2 Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Response To Prostaglandin E Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Inositol Phosphate Metabolic Process Membrane Coat Protein Tyrosine Kinase Activity	Negative Regulation Of Glycine Import Across Plasma Membrane Negative Regulation Of Dopamine Receptor Signaling Pathway Dorsal Root Ganglion Development Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Negative Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of Amino Acid Transport Response To Cocaine Positive Regulation Of Excitatory Postsynaptic Potential Tissue Development Ganglion Development G-protein Alpha-subunit Binding Negative Regulation Of Muscle Hypertrophy Response To Amphetamine Regulation Of Dopamine Receptor Signaling Pathway Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transport Negative Regulation Of Organ Growth Positive Regulation Of Heart Contraction Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Heart Rate Negative Regulation Of Cardiac Muscle Tissue Growth Response To Amine Negative Regulation Of Cardiac Muscle Hypertrophy Decidualization Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Transcription By RNA Polymerase I Negative Regulation Of Transcription By RNA Polymerase I Neural Crest Cell Differentiation Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Modulation Of Excitatory Postsynaptic Potential Negative Regulation Of G Protein-coupled Receptor Signaling Pathway
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