RGS4

Description		regulator of G protein signaling 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Protein-containing Complex
	Molecular Function	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity Calmodulin Binding Protein Kinase Binding
	Biological Process	Response To Amphetamine G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Heart Rate Response To Cocaine Response To Ethanol Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Calcium Ion Transport Negative Regulation Of Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Actin Filament Organization Negative Regulation Of Glycine Import Across Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Dorsal Root Ganglion Development Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events
Drugs
Diseases
GWAS		Daytime nap ( 33568662) Response to fenofibrate (triglyceride levels) ( 27002377) Response to mTOR inhibitor (rapamycin) ( 24009623)
Novel Interacting Genes		23 novel interacting genes: BYSL CALM1 COPB1 COPB2 DDR2 EGFR ERBB3 GABBR1 GNAI1 GNAI2 GNAO1 GNAQ KCMF1 KRIT1 MPZ OSMR PFDN2 PLCB1 PTAFR RRM1 SDHC UAP1 UBR1
Interacting Genes		23 interacting genes: BYSL CALM1 COPB1 COPB2 DDR2 EGFR ERBB3 GABBR1 GNAI1 GNAI2 GNAO1 GNAQ KCMF1 KRIT1 MPZ OSMR PFDN2 PLCB1 PTAFR RRM1 SDHC UAP1 UBR1
Entrez ID		5999
HPRD ID		03947
Ensembl ID		ENSG00000117152
Uniprot IDs		P49798
PDB IDs
Enriched GO Terms of Interacting Partners?		Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Secretion G Protein-coupled Serotonin Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Binding Positive Regulation Of Mitotic Cell Cycle Phase Transition Adenylate Cyclase Regulator Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Transport Plasma Membrane Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Acetylcholine Receptor Signaling Pathway Inositol Trisphosphate Metabolic Process Postsynaptic Signal Transduction Negative Regulation Of Secretion By Cell Regulation Of G1/S Transition Of Mitotic Cell Cycle Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Regulation Of Cell Cycle G1/S Phase Transition Cell Surface Receptor Signaling Pathway COPI Vesicle Coat Receptor Complex Regulation Of Secretion Regulation Of Peptide Hormone Secretion G Protein-coupled Receptor Binding G Protein Activity Membrane COPI-coated Vesicle Membrane Protein Tyrosine Kinase Activator Activity Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of Cell Cycle Process GABA-ergic Synapse Positive Regulation Of Cell Cycle Process Regulation Of Hormone Secretion Purinergic Nucleotide Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission ERBB2 Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Response To Prostaglandin E Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Inositol Phosphate Metabolic Process Membrane Coat Protein Tyrosine Kinase Activity
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