PRDM1 and NFIC

Number of citations of the paper that reports this interaction (PubMedID 35140242)
106

Data Source:
BioGRID (pull down)

		PRDM1	NFIC
Description		PR/SET domain 1	nuclear factor I C
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm	Chromatin Fibrillar Center Nucleus Nucleoplasm
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding Histone Methyltransferase Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Morphogenesis Of A Branching Structure Kidney Development Embryonic Placenta Development Maternal Placenta Development Adaptive Immune Response Immune System Process Heart Valve Development Cardiac Septum Development Ventricular Septum Development Regulation Of Transcription By RNA Polymerase II Germ Cell Development Post-embryonic Development Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Methylation Regulation Of Natural Killer Cell Differentiation Regulation Of Extrathymic T Cell Differentiation Aorta Development Regulation Of Cell Population Proliferation Eye Photoreceptor Cell Development Innate Immune Response Cell Fate Commitment Artery Morphogenesis Cellular Developmental Process Regulation Of NK T Cell Differentiation Retinal Bipolar Neuron Differentiation Intestinal Epithelial Cell Development Trophoblast Giant Cell Differentiation Coronary Vasculature Development Sebum Secreting Cell Proliferation	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Odontogenesis Of Dentin-containing Tooth Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Regulation of TP53 Expression STAT3 nuclear events downstream of ALK signaling Specification of primordial germ cells	RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 21102463) Diastolic blood pressure ( 30224653) Monobrow ( 27182965) Multiple myeloma ( 27363682) Response to (pegylated) interferon in HBeAG-positive hepatitis B ( 30715261) Sjögren's syndrome ( 24097067) Systemic lupus erythematosus ( 33272962 19838193 28714469 27399966 26502338 23273568 19838195) Systemic sclerosis ( 28314753) Triglyceride levels ( 32203549)	Alzheimer's disease (APOE e4 interaction) ( 28183528) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Automobile speeding propensity ( 30643258) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Height ( 20881960 31562340 28552196 25282103) High light scatter reticulocyte count ( 32888494) Hip circumference ( 28552196) Hip circumference adjusted for BMI ( 28552196) Monocyte count ( 32888494) Nevus count or cutaneous melanoma ( 30429480) Platelet count ( 32888494) Plateletcrit ( 32888494) Serum urate levels in chronic kidney disease ( 30181573) Weight ( 28552196) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		20 interacting genes: ATXN1 CFTR EXOSC3 FRK H1-1 H3C15 HNF1B HPGD IKZF3 IRF4 KDM1A MAD2L1BP MAN1A1 NFIC NFIX PIAS1 TLE1 TLE2 TLE5 UTP18	55 interacting genes: CBLC CREBBP ELK3 EPHA2 ERG ERGIC1 ETV7 FBXO7 FOS FOXL1 GATA2 GATA3 GLIS1 GLIS2 GLRX KLF16 KLF8 LATS2 LHX2 LHX3 LHX4 LLPH MAP2K3 MAPK14 MYC NFIB NSD3 PAX2 PAX6 PAX7 PAX8 PRDM1 RFX1 SFN SOX10 SOX15 SOX17 SOX2 SOX3 SOX5 SOX6 SOX9 SP7 TBR1 TBXT TEAD2 TKTL2 TLX1 TLX2 TLX3 TPD52L3 UBC YY1 ZCCHC14 ZKSCAN7
Entrez ID		639	4782
HPRD ID		04572	09009
Ensembl ID		ENSG00000057657	ENSG00000141905
Uniprot IDs		A0A3B3IU23 B4DW27 O75626 Q5T4E8	B7Z4T6 P08651
PDB IDs		3DAL
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Nucleus Regulation Of Primary Metabolic Process Transcription Corepressor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Chromatin Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Promoter-specific Chromatin Binding Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cis-regulatory Region Sequence-specific DNA Binding Transcription Regulator Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Developmental Process Positive Regulation Of Macromolecule Biosynthetic Process Animal Organ Morphogenesis DNA Binding Nucleosome Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Anoikis Regulation Of Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of DNA Recombination Positive Regulation Of RNA Metabolic Process Cell Surface Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Regulation Of Programmed Cell Death Negative Regulation Of Wnt Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Signaling Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Regulation Of Transcription By RNA Polymerase II DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Animal Organ Development Cellular Developmental Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Neuron Differentiation Nucleus Sequence-specific DNA Binding Cell Fate Specification Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Developmental Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Developmental Process Positive Regulation Of Metabolic Process Cell Fate Commitment Regulation Of Cell Differentiation Anatomical Structure Morphogenesis Negative Regulation Of Developmental Process Regulation Of MiRNA Transcription Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Regulation Of MiRNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process
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