PRDM1 and H1-1

Number of citations of the paper that reports this interaction (PubMedID 14985713)
0

Data Source:
BioGRID (enzymatic study)

		PRDM1	H1-1
Description		PR/SET domain 1	H1.1 linker histone, cluster member
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm	Chromatin Nucleosome Euchromatin Nucleus Nucleoplasm Chromosome Cell Surface Vesicle
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding Histone Methyltransferase Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	DNA Binding Double-stranded DNA Binding Protein Binding Heparin Binding Structural Constituent Of Chromatin Chromatin DNA Binding Nucleosomal DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Morphogenesis Of A Branching Structure Kidney Development Embryonic Placenta Development Maternal Placenta Development Adaptive Immune Response Immune System Process Heart Valve Development Cardiac Septum Development Ventricular Septum Development Regulation Of Transcription By RNA Polymerase II Germ Cell Development Post-embryonic Development Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Methylation Regulation Of Natural Killer Cell Differentiation Regulation Of Extrathymic T Cell Differentiation Aorta Development Regulation Of Cell Population Proliferation Eye Photoreceptor Cell Development Innate Immune Response Cell Fate Commitment Artery Morphogenesis Cellular Developmental Process Regulation Of NK T Cell Differentiation Retinal Bipolar Neuron Differentiation Intestinal Epithelial Cell Development Trophoblast Giant Cell Differentiation Coronary Vasculature Development Sebum Secreting Cell Proliferation	Nucleosome Assembly Spermatogenesis Chromosome Condensation Negative Regulation Of DNA Recombination Positive Regulation Of Receptor-mediated Endocytosis
Pathways		Regulation of TP53 Expression STAT3 nuclear events downstream of ALK signaling Specification of primordial germ cells	Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 21102463) Diastolic blood pressure ( 30224653) Monobrow ( 27182965) Multiple myeloma ( 27363682) Response to (pegylated) interferon in HBeAG-positive hepatitis B ( 30715261) Sjögren's syndrome ( 24097067) Systemic lupus erythematosus ( 33272962 19838193 28714469 27399966 26502338 23273568 19838195) Systemic sclerosis ( 28314753) Triglyceride levels ( 32203549)
Interacting Genes		20 interacting genes: ATXN1 CFTR EXOSC3 FRK H1-1 H3C15 HNF1B HPGD IKZF3 IRF4 KDM1A MAD2L1BP MAN1A1 NFIC NFIX PIAS1 TLE1 TLE2 TLE5 UTP18	54 interacting genes: AEBP2 APP CCNA1 CCNA2 CCNB1 CCND2 CCNE1 CDK1 CDK11B CDK2 CDK4 CDK5 CDK6 CDK7 CDKN1B CRP CTCFL EED EHMT2 EP300 EZH2 GADD45A GZMA IRAK4 KAT2B LIMK1 LIMK2 LOX NAP1L1 NAP1L4 NASP NSD3 PAK4 PARP1 PARP3 PELP1 PRDM1 PRKCA PRKCB PRKCD PRKCE PRKCZ PRKDC PTMA RBBP4 RPS6KA5 SET SMYD5 SNCA SUZ12 TAF1 TERF1 TERF2IP TLK1
Entrez ID		639	3024
HPRD ID		04572	00820
Ensembl ID		ENSG00000057657	ENSG00000124610
Uniprot IDs		A0A3B3IU23 B4DW27 O75626 Q5T4E8	Q02539
PDB IDs		3DAL	9J8O
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Nucleus Regulation Of Primary Metabolic Process Transcription Corepressor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Chromatin Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Promoter-specific Chromatin Binding Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cis-regulatory Region Sequence-specific DNA Binding Transcription Regulator Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Developmental Process Positive Regulation Of Macromolecule Biosynthetic Process Animal Organ Morphogenesis DNA Binding Nucleosome Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Anoikis Regulation Of Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of DNA Recombination Positive Regulation Of RNA Metabolic Process Cell Surface Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Regulation Of Programmed Cell Death Negative Regulation Of Wnt Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Signaling Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity	Chromatin Organization Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Chromatin Remodeling Nucleus Protein Kinase Activity Kinase Activity Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Nucleobase-containing Compound Metabolic Process Transferase Activity G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Protein Phosphorylation Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Phosphorylation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Mitotic Cell Cycle Phase Transition Regulation Of Metabolic Process Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Cell Cycle Cell Cycle Phase Transition Regulation Of Cell Cycle Process Negative Regulation Of Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Cellular Response To Stress Cellular Response To Oxygen-containing Compound Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone Binding Positive Regulation Of Macromolecule Metabolic Process Protein Modification Process Response To Stress Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Negative Regulation Of RNA Metabolic Process ESC/E(Z) Complex Regulation Of Cell Cycle Phase Transition Cell Division Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Localization To Chromosome
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