NFIC and KLF16

Number of citations of the paper that reports this interaction (PubMedID 35140242)
106

Data Source:
BioGRID (pull down)

		NFIC	KLF16
Description		nuclear factor I C	KLF transcription factor 16
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleus Nucleoplasm	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Odontogenesis Of Dentin-containing Tooth Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II G Protein-coupled Dopamine Receptor Signaling Pathway
Pathways		RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation	TGFBR3 expression
Drugs
Diseases
GWAS		Alzheimer's disease (APOE e4 interaction) ( 28183528) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Automobile speeding propensity ( 30643258) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Height ( 20881960 31562340 28552196 25282103) High light scatter reticulocyte count ( 32888494) Hip circumference ( 28552196) Hip circumference adjusted for BMI ( 28552196) Monocyte count ( 32888494) Nevus count or cutaneous melanoma ( 30429480) Platelet count ( 32888494) Plateletcrit ( 32888494) Serum urate levels in chronic kidney disease ( 30181573) Weight ( 28552196) Youthful appearance (self-reported) ( 32339537)	Adult body size ( 32376654) Diverticular disease ( 30177863) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil count ( 32888494) Red blood cell count ( 32888494) Reticulocyte fraction of red cells ( 32888494) White blood cell count ( 32888494)
Interacting Genes		55 interacting genes: CBLC CREBBP ELK3 EPHA2 ERG ERGIC1 ETV7 FBXO7 FOS FOXL1 GATA2 GATA3 GLIS1 GLIS2 GLRX KLF16 KLF8 LATS2 LHX2 LHX3 LHX4 LLPH MAP2K3 MAPK14 MYC NFIB NSD3 PAX2 PAX6 PAX7 PAX8 PRDM1 RFX1 SFN SOX10 SOX15 SOX17 SOX2 SOX3 SOX5 SOX6 SOX9 SP7 TBR1 TBXT TEAD2 TKTL2 TLX1 TLX2 TLX3 TPD52L3 UBC YY1 ZCCHC14 ZKSCAN7	5 interacting genes: HDAC7 NFIA NFIB NFIC SIN3A
Entrez ID		4782	83855
HPRD ID		09009	12090
Ensembl ID		ENSG00000141905	ENSG00000129911
Uniprot IDs		B7Z4T6 P08651	Q9BXK1
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Regulation Of Transcription By RNA Polymerase II DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Animal Organ Development Cellular Developmental Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Neuron Differentiation Nucleus Sequence-specific DNA Binding Cell Fate Specification Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Developmental Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Developmental Process Positive Regulation Of Metabolic Process Cell Fate Commitment Regulation Of Cell Differentiation Anatomical Structure Morphogenesis Negative Regulation Of Developmental Process Regulation Of MiRNA Transcription Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Regulation Of MiRNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process	DNA Replication Glial Cell Fate Specification Exit From Mitosis DNA Metabolic Process Generation Of Neurons Neuron Fate Specification Glial Cell Proliferation Regulation Of Transcription By RNA Polymerase II Transcription Regulator Inhibitor Activity Negative Regulation Of Transcription By RNA Polymerase II Histone Deacetylase Complex Chromatin Regulation Of DNA-templated Transcription Chromatin Binding Retina Development In Camera-type Eye Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cell Fate Specification Negative Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Lung Ciliated Cell Differentiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Response To Tert-butyl Hydroperoxide Response To Methylglyoxal Neural Precursor Cell Proliferation Regulation Of RNA Metabolic Process Neurogenesis Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Double-stranded DNA Binding Cell Differentiation Involved In Salivary Gland Development Negative Regulation Of Mesenchymal Cell Proliferation Involved In Lung Development Nucleoplasm Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Nucleic Acid Metabolic Process Principal Sensory Nucleus Of Trigeminal Nerve Development Fibrillar Center DNA Binding DNA-binding Transcription Factor Binding Club Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Response To Wounding Salivary Gland Cavitation Negative Regulation Of Biosynthetic Process Transcription Corepressor Activity Regulation Of Gene Expression Negative Regulation Of Developmental Process
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