NFIC and TLX3

Number of citations of the paper that reports this interaction (PubMedID 35140242)
106

Data Source:
BioGRID (proximity labelling technology, pull down)

		NFIC	TLX3
Description		nuclear factor I C	T cell leukemia homeobox 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleus Nucleoplasm	Chromatin Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Odontogenesis Of Dentin-containing Tooth Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Neuron Migration Regulation Of Respiratory Gaseous Exchange By Nervous System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Respiratory Gaseous Exchange By Respiratory System Neuron Differentiation Negative Regulation Of Neuron Differentiation Animal Organ Development Neuron Fate Specification GABAergic Neuron Differentiation
Pathways		RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation
Drugs
Diseases			Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Alzheimer's disease (APOE e4 interaction) ( 28183528) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Automobile speeding propensity ( 30643258) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Height ( 20881960 31562340 28552196 25282103) High light scatter reticulocyte count ( 32888494) Hip circumference ( 28552196) Hip circumference adjusted for BMI ( 28552196) Monocyte count ( 32888494) Nevus count or cutaneous melanoma ( 30429480) Platelet count ( 32888494) Plateletcrit ( 32888494) Serum urate levels in chronic kidney disease ( 30181573) Weight ( 28552196) Youthful appearance (self-reported) ( 32339537)	Body size at age 10 ( 32376654)
Interacting Genes		55 interacting genes: CBLC CREBBP ELK3 EPHA2 ERG ERGIC1 ETV7 FBXO7 FOS FOXL1 GATA2 GATA3 GLIS1 GLIS2 GLRX KLF16 KLF8 LATS2 LHX2 LHX3 LHX4 LLPH MAP2K3 MAPK14 MYC NFIB NSD3 PAX2 PAX6 PAX7 PAX8 PRDM1 RFX1 SFN SOX10 SOX15 SOX17 SOX2 SOX3 SOX5 SOX6 SOX9 SP7 TBR1 TBXT TEAD2 TKTL2 TLX1 TLX2 TLX3 TPD52L3 UBC YY1 ZCCHC14 ZKSCAN7	108 interacting genes: ACTMAP ACY1 AKAP9 ANKRD10 ANKRD33 AOC1 APBB1IP ARMC5 ASB12 ATP6V0D1 B9D2 BPIFA1 C2orf42 CEACAM6 CFAP68 CIMIP2B CRX CSNK2B CTNNA3 DENND4A EFEMP2 ERAS FAM168B FCSK FNTB FOSB FOXH1 GGTLC2 GOLGA6L9 GTF2A1L H2BC11 HNF1B HNRNPUL1 HOPX HSPB2 HSPB2-C11orf52 HYI IGFL2 ING4 INTS11 IRF9 ITIH6 KCNJ5-AS1 KRT34 KRTAP11-1 KRTAP13-3 KRTAP19-1 KRTAP19-7 KRTAP3-1 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 LASP1 LMO2 MAGED1 MEIS1 METTL27 MORN5 MSX2 NDUFAB1 NFIC NFIX NHLRC4 NICN1 OIP5 PLA2G10 PLAAT1 POU2AF1 POU6F2 PPP1CC PQBP1 PRR20A PRR20B PRR20C PRR20D PRR20E PSMB11 REL ROR2 RSKR SERPINE1 SLC15A2 SMU1 SNTA1 SP1 SPATA46 SPMIP9 SPRYD7 STH SYNGAP1 TBX22 TCIRG1 TEKT5 THTPA TLE2 TMEM42 TOX2 TP53BP1 TRIM42 UFSP1 WDR83 YPEL3 ZBTB32 ZNF34 ZNF41 ZNF44
Entrez ID		4782	30012
HPRD ID		09009	06868
Ensembl ID		ENSG00000141905	ENSG00000164438
Uniprot IDs		B7Z4T6 P08651	O43711
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Regulation Of Transcription By RNA Polymerase II DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Animal Organ Development Cellular Developmental Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Neuron Differentiation Nucleus Sequence-specific DNA Binding Cell Fate Specification Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Developmental Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Developmental Process Positive Regulation Of Metabolic Process Cell Fate Commitment Regulation Of Cell Differentiation Anatomical Structure Morphogenesis Negative Regulation Of Developmental Process Regulation Of MiRNA Transcription Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Regulation Of MiRNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process	Intermediate Filament Protein Binding Chromatin
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