PTGFR and PTGER2

Number of citations of the paper that reports this interaction (PubMedID 8163486)
0

Data Source:
HPRD (in vivo)

		PTGFR	PTGER2
Description		prostaglandin F receptor	prostaglandin E receptor 2
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane Membrane	Plasma Membrane Membrane
	Molecular Function	G Protein-coupled Receptor Activity Prostaglandin F Receptor Activity	G Protein-coupled Receptor Activity Prostaglandin E Receptor Activity
	Biological Process	Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Parturition Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Response To Estradiol Response To Lipopolysaccharide Response To Lipid Negative Regulation Of Apoptotic Process Cellular Response To Prostaglandin D Stimulus	Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Nematode Response To Lipopolysaccharide Response To Progesterone Regulation Of Cell Population Proliferation Cellular Response To Prostaglandin E Stimulus
Pathways		Prostanoid ligand receptors G alpha (q) signalling events	Prostanoid ligand receptors G alpha (s) signalling events
Drugs		Travoprost Latanoprost Bimatoprost Dinoprost tromethamine Tafluprost Latanoprostene bunod	Treprostinil Alprostadil Dinoprostone Misoprostol Trichostatin A Gemeprost Limaprost Omidenepag isopropyl Rivenprost
Diseases
GWAS		Bipolar disorder ( 22182935) Depression in multiple sclerosis (post-diagnosis) ( 33296963) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Lung function in never smokers (high FEV1 vs average FEV1) ( 26423011) Skin fluorescence in type 1 diabetes ( 27207532) Systolic blood pressure (alcohol consumption interaction) ( 24376456)
Interacting Genes		12 interacting genes: AGTR1 CTH FPGT GTPBP4 IKBKE NOC2L PHOX2B PTGDS PTGER1 PTGER2 PTGES2 PTPRT	3 interacting genes: PTGDS PTGES PTGFR
Entrez ID		5737	5732
HPRD ID		08988	08905
Ensembl ID		ENSG00000122420	ENSG00000125384
Uniprot IDs		P43088	P43116
PDB IDs		8IQ4 8IQ6 8IUK 8IUL 8IUM 8XJK 8XJL 8XJM	7CX2 7CX3 7CX4
Enriched GO Terms of Interacting Partners?		Prostaglandin E Receptor Activity Prostaglandin Biosynthetic Process Prostanoid Biosynthetic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Angiotensin Type I Receptor Activity L-cystine L-cysteine-lyase (deaminating) L-cysteine Desulfhydrase Activity Homocysteine Desulfhydrase Activity Selenocystathionine Gamma-lyase Activity Cystathionine Gamma-lyase Activity Carboxylic Acid Biosynthetic Process Protein Sulfhydration Protein-pyridoxal-5-phosphate Linkage Via Peptidyl-N6-pyridoxal Phosphate-L-lysine Prostanoid Metabolic Process Prostaglandin Metabolic Process Unsaturated Fatty Acid Biosynthetic Process Icosanoid Biosynthetic Process Response To Prostaglandin E Fucose-1-phosphate Guanylyltransferase Activity Efferent Axon Development In A Lateral Line Nerve Medullary Reticular Formation Development Retrotrapezoid Nucleus Neuron Differentiation Ribosomal Large Subunit Biogenesis Noc2p-Noc3p Complex Noc1p-Noc2p Complex G Protein-coupled Receptor Activity Phospholipase C-activating Angiotensin-activated Signaling Pathway Bradykinin Receptor Binding Renin-angiotensin Regulation Of Aldosterone Production Cysteine Biosynthetic Process Via Cystathionine Positive Regulation Of Aortic Smooth Muscle Cell Differentiation Unsaturated Fatty Acid Metabolic Process Icosanoid Metabolic Process Prostaglandin-D Synthase Activity Negative Regulation Of Male Germ Cell Proliferation Parasympathetic Nervous System Development Cellular Response To Carbon Dioxide Negative Regulation Of Type B Pancreatic Cell Proliferation Response To Carbon Dioxide Protein Phosphatase Binding IkappaB Kinase Activity 12-hydroxyheptadecatrienoic Acid Synthase Activity Prostaglandin-E Synthase Activity Regulation Of G2/M Transition Of Mitotic Cell Cycle Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Angiotensin Type II Receptor Activity Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Small Molecule Biosynthetic Process Cysteine Biosynthetic Process Transsulfuration	Prostaglandin-D Synthase Activity Prostaglandin Biosynthetic Process Prostanoid Biosynthetic Process Prostanoid Metabolic Process Prostaglandin Metabolic Process Unsaturated Fatty Acid Biosynthetic Process Icosanoid Biosynthetic Process Unsaturated Fatty Acid Metabolic Process Icosanoid Metabolic Process Fatty Acid Biosynthetic Process Prostaglandin F Receptor Activity Isomerase Activity Negative Regulation Of Male Germ Cell Proliferation Prostaglandin-E Synthase Activity Carboxylic Acid Biosynthetic Process Fatty Acid Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Male Germ Cell Proliferation Regulation Of Germ Cell Proliferation Cellular Response To Prostaglandin D Stimulus Regulation Of Fever Generation Parturition Retinoid Binding Glutathione Binding Small Molecule Biosynthetic Process Nuclear Envelope Lumen Monocarboxylic Acid Metabolic Process Positive Regulation Of Prostaglandin Secretion Lipid Biosynthetic Process Positive Regulation Of Icosanoid Secretion Regulation Of Circadian Sleep/wake Cycle, Sleep Glutathione Peroxidase Activity Positive Regulation Of Fatty Acid Transport Response To Hormone Regulation Of Circadian Sleep/wake Cycle Mast Cell Degranulation Small Molecule Binding Cellular Response To Prostaglandin Stimulus Negative Regulation Of Cell Population Proliferation Fatty Acid Binding Organic Acid Metabolic Process Perinuclear Region Of Cytoplasm Carboxylic Acid Metabolic Process Glutathione Transferase Activity Regulation Of Fatty Acid Transport Rough Endoplasmic Reticulum Response To Lipid Leukocyte Degranulation Sensory Perception Of Pain Regulation Of Acute Inflammatory Response
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