PTGFR and PHOX2B

		PTGFR	PHOX2B
Description		prostaglandin F receptor	paired like homeobox 2B
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane Membrane	Chromatin Nucleus Nucleoplasm
	Molecular Function	G Protein-coupled Receptor Activity Prostaglandin F Receptor Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Parturition Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Response To Estradiol Response To Lipopolysaccharide Response To Lipid Negative Regulation Of Apoptotic Process Cellular Response To Prostaglandin D Stimulus	Neuron Migration Regulation Of Respiratory Gaseous Exchange By Nervous System Process Noradrenergic Neuron Differentiation Noradrenergic Neuron Development Brainstem Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Population Proliferation Glial Cell Differentiation Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Response To Activity Cell Differentiation In Hindbrain Medullary Reticular Formation Development Hindbrain Tangential Cell Migration Neuron Differentiation Skeletal Muscle Cell Differentiation Type B Pancreatic Cell Proliferation Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cell Development Autonomic Nervous System Development Enteric Nervous System Development Sympathetic Nervous System Development Parasympathetic Nervous System Development Neuron Development Inner Ear Development Efferent Axon Development In A Lateral Line Nerve Membrane Depolarization Respiratory System Development Retrotrapezoid Nucleus Neuron Differentiation Sympathetic Ganglion Development Cellular Response To Carbon Dioxide Dopaminergic Neuron Differentiation Cellular Response To BMP Stimulus Motor Neuron Migration Positive Regulation Of Cold-induced Thermogenesis Neural Crest Cell Migration Involved In Autonomic Nervous System Development Negative Regulation Of Type B Pancreatic Cell Proliferation
Pathways		Prostanoid ligand receptors G alpha (q) signalling events
Drugs		Travoprost Latanoprost Bimatoprost Dinoprost tromethamine Tafluprost Latanoprostene bunod
Diseases			Congenital central hypoventilation syndrome (CCHS)
GWAS		Bipolar disorder ( 22182935) Depression in multiple sclerosis (post-diagnosis) ( 33296963) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Lung function in never smokers (high FEV1 vs average FEV1) ( 26423011) Skin fluorescence in type 1 diabetes ( 27207532) Systolic blood pressure (alcohol consumption interaction) ( 24376456)	Bone mineral density (femoral neck) ( 26911590) Hirschsprung disease ( 27702942)
Interacting Genes		12 interacting genes: AGTR1 CTH FPGT GTPBP4 IKBKE NOC2L PHOX2B PTGDS PTGER1 PTGER2 PTGES2 PTPRT	1 interacting genes: PTGFR
Entrez ID		5737	8929
HPRD ID		08988	09157
Ensembl ID		ENSG00000122420	ENSG00000109132
Uniprot IDs		P43088	Q99453
PDB IDs		8IQ4 8IQ6 8IUK 8IUL 8IUM 8XJK 8XJL 8XJM	7MJA 8EK5 8P7G 8PTL 8PUI
Enriched GO Terms of Interacting Partners?		Prostaglandin E Receptor Activity Prostaglandin Biosynthetic Process Prostanoid Biosynthetic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Angiotensin Type I Receptor Activity L-cystine L-cysteine-lyase (deaminating) L-cysteine Desulfhydrase Activity Homocysteine Desulfhydrase Activity Selenocystathionine Gamma-lyase Activity Cystathionine Gamma-lyase Activity Carboxylic Acid Biosynthetic Process Protein Sulfhydration Protein-pyridoxal-5-phosphate Linkage Via Peptidyl-N6-pyridoxal Phosphate-L-lysine Prostanoid Metabolic Process Prostaglandin Metabolic Process Unsaturated Fatty Acid Biosynthetic Process Icosanoid Biosynthetic Process Response To Prostaglandin E Fucose-1-phosphate Guanylyltransferase Activity Efferent Axon Development In A Lateral Line Nerve Medullary Reticular Formation Development Retrotrapezoid Nucleus Neuron Differentiation Ribosomal Large Subunit Biogenesis Noc2p-Noc3p Complex Noc1p-Noc2p Complex G Protein-coupled Receptor Activity Phospholipase C-activating Angiotensin-activated Signaling Pathway Bradykinin Receptor Binding Renin-angiotensin Regulation Of Aldosterone Production Cysteine Biosynthetic Process Via Cystathionine Positive Regulation Of Aortic Smooth Muscle Cell Differentiation Unsaturated Fatty Acid Metabolic Process Icosanoid Metabolic Process Prostaglandin-D Synthase Activity Negative Regulation Of Male Germ Cell Proliferation Parasympathetic Nervous System Development Cellular Response To Carbon Dioxide Negative Regulation Of Type B Pancreatic Cell Proliferation Response To Carbon Dioxide Protein Phosphatase Binding IkappaB Kinase Activity 12-hydroxyheptadecatrienoic Acid Synthase Activity Prostaglandin-E Synthase Activity Regulation Of G2/M Transition Of Mitotic Cell Cycle Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Angiotensin Type II Receptor Activity Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Small Molecule Biosynthetic Process Cysteine Biosynthetic Process Transsulfuration	Prostaglandin F Receptor Activity Cellular Response To Prostaglandin D Stimulus Parturition Cellular Response To Prostaglandin Stimulus Response To Estradiol
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