PTGFR and GTPBP4

		PTGFR	GTPBP4
Description		prostaglandin F receptor	GTP binding protein 4
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane Membrane	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Nuclear Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	G Protein-coupled Receptor Activity Prostaglandin F Receptor Activity	Nucleotide Binding RNA Binding GTPase Activity Protein Binding GTP Binding Preribosome Binding
	Biological Process	Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Parturition Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Response To Estradiol Response To Lipopolysaccharide Response To Lipid Negative Regulation Of Apoptotic Process Cellular Response To Prostaglandin D Stimulus	Maturation Of LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Osteoblast Differentiation Negative Regulation Of DNA Replication Negative Regulation Of Cell Population Proliferation Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Migration Negative Regulation Of Protein Ubiquitination Ribosome Biogenesis Ribosomal Large Subunit Biogenesis Protein Stabilization
Pathways		Prostanoid ligand receptors G alpha (q) signalling events
Drugs		Travoprost Latanoprost Bimatoprost Dinoprost tromethamine Tafluprost Latanoprostene bunod
Diseases
GWAS		Bipolar disorder ( 22182935) Depression in multiple sclerosis (post-diagnosis) ( 33296963) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Lung function in never smokers (high FEV1 vs average FEV1) ( 26423011) Skin fluorescence in type 1 diabetes ( 27207532) Systolic blood pressure (alcohol consumption interaction) ( 24376456)	Height ( 28552196)
Interacting Genes		12 interacting genes: AGTR1 CTH FPGT GTPBP4 IKBKE NOC2L PHOX2B PTGDS PTGER1 PTGER2 PTGES2 PTPRT	10 interacting genes: COPB1 GGA1 GGA2 GGA3 IL2RA PRKN PTGFR SRPK2 USP7 YWHAG
Entrez ID		5737	23560
HPRD ID		08988	09976
Ensembl ID		ENSG00000122420	ENSG00000107937
Uniprot IDs		P43088	D2CFK9 Q9BZE4
PDB IDs		8IQ4 8IQ6 8IUK 8IUL 8IUM 8XJK 8XJL 8XJM	6LSS 6LU8 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8IDT 8IDY 8IE3 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8RL2
Enriched GO Terms of Interacting Partners?		Prostaglandin E Receptor Activity Prostaglandin Biosynthetic Process Prostanoid Biosynthetic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Angiotensin Type I Receptor Activity L-cystine L-cysteine-lyase (deaminating) L-cysteine Desulfhydrase Activity Homocysteine Desulfhydrase Activity Selenocystathionine Gamma-lyase Activity Cystathionine Gamma-lyase Activity Carboxylic Acid Biosynthetic Process Protein Sulfhydration Protein-pyridoxal-5-phosphate Linkage Via Peptidyl-N6-pyridoxal Phosphate-L-lysine Prostanoid Metabolic Process Prostaglandin Metabolic Process Unsaturated Fatty Acid Biosynthetic Process Icosanoid Biosynthetic Process Response To Prostaglandin E Fucose-1-phosphate Guanylyltransferase Activity Efferent Axon Development In A Lateral Line Nerve Medullary Reticular Formation Development Retrotrapezoid Nucleus Neuron Differentiation Ribosomal Large Subunit Biogenesis Noc2p-Noc3p Complex Noc1p-Noc2p Complex G Protein-coupled Receptor Activity Phospholipase C-activating Angiotensin-activated Signaling Pathway Bradykinin Receptor Binding Renin-angiotensin Regulation Of Aldosterone Production Cysteine Biosynthetic Process Via Cystathionine Positive Regulation Of Aortic Smooth Muscle Cell Differentiation Unsaturated Fatty Acid Metabolic Process Icosanoid Metabolic Process Prostaglandin-D Synthase Activity Negative Regulation Of Male Germ Cell Proliferation Parasympathetic Nervous System Development Cellular Response To Carbon Dioxide Negative Regulation Of Type B Pancreatic Cell Proliferation Response To Carbon Dioxide Protein Phosphatase Binding IkappaB Kinase Activity 12-hydroxyheptadecatrienoic Acid Synthase Activity Prostaglandin-E Synthase Activity Regulation Of G2/M Transition Of Mitotic Cell Cycle Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Angiotensin Type II Receptor Activity Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Small Molecule Biosynthetic Process Cysteine Biosynthetic Process Transsulfuration	Ubiquitin Binding Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Regulation Of Retrograde Transport, Endosome To Golgi Golgi Vesicle Transport Post-Golgi Vesicle-mediated Transport Phosphatidylinositol Binding Regulation Of Protein Stability Regulation Of Protein Catabolic Process Vesicle-mediated Transport To The Plasma Membrane Protein K6-linked Ubiquitination Intracellular Protein Localization Intracellular Protein Transport Positive Regulation Of Catabolic Process Positive Regulation Of Protein Catabolic Process Protein Localization To Plasma Membrane Early Endosome Membrane Establishment Of Protein Localization To Membrane Trans-Golgi Network Vesicle-mediated Transport Intracellular Transport Presynapse Protein Stabilization Protein Catabolic Process Protein Localization To Cell Periphery Protein Localization To Organelle Establishment Of Protein Localization Golgi Apparatus Protein Destabilization Protein Localization To Lysosome Endosome Membrane Small GTPase Binding Negative Regulation Of Spontaneous Neurotransmitter Secretion Prostaglandin F Receptor Activity TORC1 Signaling Protein Localization To Membrane Protein-containing Complex Negative Regulation Of TORC1 Signaling Positive Regulation Of Protein Metabolic Process Cellular Localization Positive Regulation Of Metabolic Process Negative Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Establishment Of Localization In Cell Interleukin-2 Receptor Complex Positive Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Intralumenal Vesicle Formation Positive Regulation Of Protein Linear Polyubiquitination
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