PTGFR and PTGES2

Number of citations of the paper that reports this interaction (PubMedID 8300593)
0

Data Source:
HPRD (in vivo)

		PTGFR	PTGES2
Description		prostaglandin F receptor	prostaglandin E synthase 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane Membrane	Golgi Membrane Extracellular Region Nucleus Cytoplasm Mitochondrion Golgi Apparatus Cytosol Membrane Azurophil Granule Lumen Perinuclear Region Of Cytoplasm
	Molecular Function	G Protein-coupled Receptor Activity Prostaglandin F Receptor Activity	DNA Binding Protein Binding Lyase Activity Isomerase Activity Heme Binding 12-hydroxyheptadecatrienoic Acid Synthase Activity Glutathione Binding Prostaglandin-E Synthase Activity
	Biological Process	Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Parturition Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Response To Estradiol Response To Lipopolysaccharide Response To Lipid Negative Regulation Of Apoptotic Process Cellular Response To Prostaglandin D Stimulus	Prostaglandin Biosynthetic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Prostaglandin Metabolic Process Positive Regulation Of DNA-templated Transcription Prostanoid Biosynthetic Process Secretion
Pathways		Prostanoid ligand receptors G alpha (q) signalling events	Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Neutrophil degranulation
Drugs		Travoprost Latanoprost Bimatoprost Dinoprost tromethamine Tafluprost Latanoprostene bunod
Diseases			Penile cancer
GWAS		Bipolar disorder ( 22182935) Depression in multiple sclerosis (post-diagnosis) ( 33296963) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Lung function in never smokers (high FEV1 vs average FEV1) ( 26423011) Skin fluorescence in type 1 diabetes ( 27207532) Systolic blood pressure (alcohol consumption interaction) ( 24376456)	Body mass index ( 26426971)
Interacting Genes		12 interacting genes: AGTR1 CTH FPGT GTPBP4 IKBKE NOC2L PHOX2B PTGDS PTGER1 PTGER2 PTGES2 PTPRT	10 interacting genes: ADRB2 C9orf78 CEBPB CFAP141 COL23A1 CRY2 EXOSC10 HSPA13 PTGFR RPL27A
Entrez ID		5737	80142
HPRD ID		08988	07458
Ensembl ID		ENSG00000122420	ENSG00000148334
Uniprot IDs		P43088	A0A7I2V5X6 A6NHH0 B3KPZ2 B4DWP1 Q9H7Z7
PDB IDs		8IQ4 8IQ6 8IUK 8IUL 8IUM 8XJK 8XJL 8XJM
Enriched GO Terms of Interacting Partners?		Prostaglandin E Receptor Activity Prostaglandin Biosynthetic Process Prostanoid Biosynthetic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Angiotensin Type I Receptor Activity L-cystine L-cysteine-lyase (deaminating) L-cysteine Desulfhydrase Activity Homocysteine Desulfhydrase Activity Selenocystathionine Gamma-lyase Activity Cystathionine Gamma-lyase Activity Carboxylic Acid Biosynthetic Process Protein Sulfhydration Protein-pyridoxal-5-phosphate Linkage Via Peptidyl-N6-pyridoxal Phosphate-L-lysine Prostanoid Metabolic Process Prostaglandin Metabolic Process Unsaturated Fatty Acid Biosynthetic Process Icosanoid Biosynthetic Process Response To Prostaglandin E Fucose-1-phosphate Guanylyltransferase Activity Efferent Axon Development In A Lateral Line Nerve Medullary Reticular Formation Development Retrotrapezoid Nucleus Neuron Differentiation Ribosomal Large Subunit Biogenesis Noc2p-Noc3p Complex Noc1p-Noc2p Complex G Protein-coupled Receptor Activity Phospholipase C-activating Angiotensin-activated Signaling Pathway Bradykinin Receptor Binding Renin-angiotensin Regulation Of Aldosterone Production Cysteine Biosynthetic Process Via Cystathionine Positive Regulation Of Aortic Smooth Muscle Cell Differentiation Unsaturated Fatty Acid Metabolic Process Icosanoid Metabolic Process Prostaglandin-D Synthase Activity Negative Regulation Of Male Germ Cell Proliferation Parasympathetic Nervous System Development Cellular Response To Carbon Dioxide Negative Regulation Of Type B Pancreatic Cell Proliferation Response To Carbon Dioxide Protein Phosphatase Binding IkappaB Kinase Activity 12-hydroxyheptadecatrienoic Acid Synthase Activity Prostaglandin-E Synthase Activity Regulation Of G2/M Transition Of Mitotic Cell Cycle Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Angiotensin Type II Receptor Activity Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Small Molecule Biosynthetic Process Cysteine Biosynthetic Process Transsulfuration	Regulation Of Sodium-dependent Phosphate Transport Regulation Of Phosphate Transport Brown Fat Cell Differentiation Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Mini Excitatory Postsynaptic Potential Photoreactive Repair Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Prostaglandin F Receptor Activity Beta2-adrenergic Receptor Activity Granuloma Formation C/EBP Complex Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Nuclear Polyadenylation-dependent SnoRNA Catabolic Process Nuclear Polyadenylation-dependent SnRNA Catabolic Process Nuclear Polyadenylation-dependent CUT Catabolic Process Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Positive Regulation Of Cold-induced Thermogenesis T-helper 1 Cell Activation Kinase Binding CHOP-C/EBP Complex Positive Regulation Of Sodium-dependent Phosphate Transport Cry-Per Complex Regulation Of Homologous Chromosome Segregation U5 SnRNA Binding Norepinephrine Binding Negative Regulation Of Glucocorticoid Secretion Sno(s)RNA Catabolic Process Positive Regulation Of MRNA Cis Splicing, Via Spliceosome Response To Psychosocial Stress Fat Cell Differentiation Positive Regulation Of Lipophagy AMPA Selective Glutamate Receptor Signaling Pathway SnRNA Catabolic Process CUT Catabolic Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Autophagosome Maturation Regulation Of Cold-induced Thermogenesis Heat Generation Nucleic Acid Metabolic Process Hepatocyte Proliferation Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Response To Blue Light Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway
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