GTPBP4 and GGA2

Number of citations of the paper that reports this interaction (PubMedID 37219487)
66

Data Source:
BioGRID (unspecified method)

		GTPBP4	GGA2
Description		GTP binding protein 4	golgi associated, gamma adaptin ear containing, ARF binding protein 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Nuclear Membrane Perinuclear Region Of Cytoplasm	Endosome Golgi Apparatus Trans-Golgi Network Endosome Membrane Membrane Clathrin-coated Vesicle Early Endosome Membrane
	Molecular Function	Nucleotide Binding RNA Binding GTPase Activity Protein Binding GTP Binding Preribosome Binding	Protein Binding Small GTPase Binding Phosphatidylinositol Binding Ubiquitin Binding
	Biological Process	Maturation Of LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Osteoblast Differentiation Negative Regulation Of DNA Replication Negative Regulation Of Cell Population Proliferation Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Migration Negative Regulation Of Protein Ubiquitination Ribosome Biogenesis Ribosomal Large Subunit Biogenesis Protein Stabilization	Intracellular Protein Transport Golgi To Plasma Membrane Transport Protein Transport Vesicle-mediated Transport Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport
Pathways			TBC/RABGAPs Amyloid fiber formation
Drugs
Diseases
GWAS		Height ( 28552196)
Interacting Genes		10 interacting genes: COPB1 GGA1 GGA2 GGA3 IL2RA PRKN PTGFR SRPK2 USP7 YWHAG	43 interacting genes: ADRA2B AFTPH AP1G1 APP ARF1 ARF3 ATXN1 BACE1 BACE2 CA8 CCDC91 CLINT1 CLTC ETS1 FBXO7 GGA1 GGA3 GOLGA2 GTPBP4 HGS HTT IGF2R JUN LRP3 M6PR MAP3K1 MEMO1 NPM1 PIN1 RABEP1 RABGEF1 RNF11 RTN4IP1 SORL1 SORT1 SPG21 STAB1 SYNRG TOLLIP TP53 TRIM23 VPS18 ZNF536
Entrez ID		23560	23062
HPRD ID		09976	09347
Ensembl ID		ENSG00000107937	ENSG00000103365
Uniprot IDs		D2CFK9 Q9BZE4	Q9UJY4
PDB IDs		6LSS 6LU8 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8IDT 8IDY 8IE3 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8RL2	1MHQ
Enriched GO Terms of Interacting Partners?		Ubiquitin Binding Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Regulation Of Retrograde Transport, Endosome To Golgi Golgi Vesicle Transport Post-Golgi Vesicle-mediated Transport Phosphatidylinositol Binding Regulation Of Protein Stability Regulation Of Protein Catabolic Process Vesicle-mediated Transport To The Plasma Membrane Protein K6-linked Ubiquitination Intracellular Protein Localization Intracellular Protein Transport Positive Regulation Of Catabolic Process Positive Regulation Of Protein Catabolic Process Protein Localization To Plasma Membrane Early Endosome Membrane Establishment Of Protein Localization To Membrane Trans-Golgi Network Vesicle-mediated Transport Intracellular Transport Presynapse Protein Stabilization Protein Catabolic Process Protein Localization To Cell Periphery Protein Localization To Organelle Establishment Of Protein Localization Golgi Apparatus Protein Destabilization Protein Localization To Lysosome Endosome Membrane Small GTPase Binding Negative Regulation Of Spontaneous Neurotransmitter Secretion Prostaglandin F Receptor Activity TORC1 Signaling Protein Localization To Membrane Protein-containing Complex Negative Regulation Of TORC1 Signaling Positive Regulation Of Protein Metabolic Process Cellular Localization Positive Regulation Of Metabolic Process Negative Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Establishment Of Localization In Cell Interleukin-2 Receptor Complex Positive Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Intralumenal Vesicle Formation Positive Regulation Of Protein Linear Polyubiquitination	Vesicle-mediated Transport Intracellular Transport Early Endosome Endosome Cellular Localization Establishment Of Protein Localization Establishment Of Localization In Cell Protein Transport Intracellular Protein Transport Endocytosis Golgi Apparatus Lysosomal Transport Trans-Golgi Network Import Into Cell Intracellular Protein Localization Vacuolar Transport Clathrin-coated Vesicle Golgi Vesicle Transport Recycling Endosome Post-Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Protein Targeting To Lysosome Protein Targeting Perinuclear Region Of Cytoplasm Establishment Of Protein Localization To Organelle Protein Targeting To Vacuole Protein-containing Complex Trans-Golgi Network Membrane Protein Localization To Lysosome Endosome Membrane Establishment Of Protein Localization To Vacuole Early Endosome Membrane Cytoplasmic Vesicle Cytosolic Transport Clathrin-coated Pit Retromer Complex Binding Golgi To Lysosome Transport Nuclear Envelope Lumen Lysosome Protein Localization To Organelle AP-1 Adaptor Complex Endosomal Transport Protein Localization To Vacuole Ubiquitin Binding Protein Transporter Activity Regulation Of Amyloid Precursor Protein Catabolic Process Trans-Golgi Network Transport Vesicle Golgi To Vacuole Transport Vesicle-mediated Transport To The Plasma Membrane Amyloid-beta Metabolic Process
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