MARCHF2 and SYNE4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		MARCHF2	SYNE4
Description		membrane associated ring-CH-type finger 2	spectrin repeat containing nuclear envelope family member 4
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle	Nucleus Nuclear Envelope Nuclear Outer Membrane Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Endocytosis Protein Ubiquitination Suppression Of Viral Release By Host Antibacterial Innate Immune Response Antiviral Innate Immune Response Positive Regulation Of Lysosomal Protein Catabolic Process	Establishment Of Epithelial Cell Apical/basal Polarity
Pathways
Drugs
Diseases
GWAS
Interacting Genes		36 interacting genes: AQP6 CCL4 CD79A CDC34 CFTR CREB3L1 ECSIT ERGIC3 F11R FAM209A FATE1 FBXL12 GJA8 GPX8 IKBKG KASH5 LDLRAD1 LGR4 MUC1 PEX12 PLPPR2 SCN3B SLC18A1 SSMEM1 STX6 SYNE4 TMEM106C TMEM179B TMEM52B TMEM86B TSPAN12 TSPO2 UBC UBE2D1 UBE2E1 UBE2H	57 interacting genes: ABT1 ADIPOQ BRICD5 C3orf52 CD47 CEP19 CFTR CLDN19 CLDN7 CLDN8 CLEC7A CMTM5 CSNK2B CXCL9 DEFB121 ECE2 EDDM3B EMP1 ENTPD3 FAM241B FATE1 GADD45A GSK3B IGFBP5 ITM2B KLHL12 KLRG1 KTN1 MALL MARCHF2 NAGK OCLN OLFM4 OSTCP1 PAQR5 PLPP6 RIPPLY2 RPS6KA6 SEC22A SEC23B SENP2 SFTPC SLN SMCO4 TCEA2 TMEM115 TMEM140 TMEM147 TMEM182 TMEM248 TMPRSS4 TRIM69 TSPAN15 VTI1B WDR62 ZNF250 ZNF648
Entrez ID		51257	163183
HPRD ID		14361	08776
Ensembl ID		ENSG00000099785	ENSG00000181392
Uniprot IDs		Q9P0N8	Q8N205
PDB IDs			6R16 6WMD
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Membrane Protein Binding Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Modification-dependent Protein Catabolic Process Meiotic Nuclear Membrane Microtubule Tethering Complex Protein Ubiquitination Endoplasmic Reticulum Membrane Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation	Protein Binding Bicellular Tight Junction Assembly Tight Junction Organization Tight Junction Assembly Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Apicolateral Plasma Membrane Regulation Of Glycogen (starch) Synthase Activity
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