SYNE4 and ITM2B

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		SYNE4	ITM2B
Description		spectrin repeat containing nuclear envelope family member 4	integral membrane protein 2B
Image
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Outer Membrane Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex	Golgi Membrane Extracellular Region Extracellular Space Endosome Golgi Apparatus Plasma Membrane Endosome Membrane Membrane Golgi-associated Vesicle Membrane Organelle Membrane Extracellular Exosome
	Molecular Function	Protein Binding	Amyloid-beta Binding Protein Binding ATP Binding
	Biological Process	Establishment Of Epithelial Cell Apical/basal Polarity	Nervous System Development Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process
Pathways			Amyloid fiber formation
Drugs
Diseases
GWAS			Severe insulin-deficient type 2 diabetes ( 34737425)
Interacting Genes		57 interacting genes: ABT1 ADIPOQ BRICD5 C3orf52 CD47 CEP19 CFTR CLDN19 CLDN7 CLDN8 CLEC7A CMTM5 CSNK2B CXCL9 DEFB121 ECE2 EDDM3B EMP1 ENTPD3 FAM241B FATE1 GADD45A GSK3B IGFBP5 ITM2B KLHL12 KLRG1 KTN1 MALL MARCHF2 NAGK OCLN OLFM4 OSTCP1 PAQR5 PLPP6 RIPPLY2 RPS6KA6 SEC22A SEC23B SENP2 SFTPC SLN SMCO4 TCEA2 TMEM115 TMEM140 TMEM147 TMEM182 TMEM248 TMPRSS4 TRIM69 TSPAN15 VTI1B WDR62 ZNF250 ZNF648	7 interacting genes: APP BCL2 CREB3 KASH5 LMNA NAALADL2 SYNE4
Entrez ID		163183	9445
HPRD ID		08776	04878
Ensembl ID		ENSG00000181392	ENSG00000136156
Uniprot IDs		Q8N205	A0A384MDP7 Q9Y287
PDB IDs		6R16 6WMD	8RNU
Enriched GO Terms of Interacting Partners?		Protein Binding Bicellular Tight Junction Assembly Tight Junction Organization Tight Junction Assembly Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Apicolateral Plasma Membrane Regulation Of Glycogen (starch) Synthase Activity	Regulation Of Apoptotic Signaling Pathway Meiotic Nuclear Membrane Microtubule Tethering Complex Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Neuron Maturation Regulation Of Calcium Ion Transport Positive Regulation Of Monocyte Chemotaxis Regulation Of Monocyte Chemotaxis Negative Regulation Of Apoptotic Signaling Pathway Nuclear Envelope Nuclear Outer Membrane Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Cell Migration Regulation Of Multicellular Organism Growth Amylin Binding Positive Regulation Of Toll Signaling Pathway Cell Development Regulation Of Metal Ion Transport Regulation Of Cell Motility Identical Protein Binding Negative Regulation Of Retinal Cell Programmed Cell Death Negative Regulation Of Cellular PH Reduction Striated Muscle Cell Development Positive Regulation Of Deacetylase Activity Regulation Of Monoatomic Ion Transport Regulation Of Locomotion Chromosome Localization Acetylcholine Receptor Activator Activity Positive Regulation Of Mononuclear Cell Migration Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Leukocyte Chemotaxis Lipoprotein Particle Positive Regulation Of Protein Import Supramolecular Fiber Organization Muscle Cell Development CD8-positive, Alpha-beta T Cell Lineage Commitment BAD-BCL-2 Complex Channel Inhibitor Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Meiotic Spindle Pole PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?