SYNE4 and KLRG1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		SYNE4	KLRG1
Description		spectrin repeat containing nuclear envelope family member 4	killer cell lectin like receptor G1
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Outer Membrane Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex	Plasma Membrane Membrane
	Molecular Function	Protein Binding	Protein Binding Carbohydrate Binding Signaling Receptor Activity
	Biological Process	Establishment Of Epithelial Cell Apical/basal Polarity	Immune System Process Inflammatory Response Cellular Defense Response Cell Surface Receptor Signaling Pathway Innate Immune Response
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS			Appendicular lean mass ( 33097823) Refractive error ( 32231278) Sjögren's syndrome ( 28076899) Type 1 diabetes ( 34012112)
Interacting Genes		57 interacting genes: ABT1 ADIPOQ BRICD5 C3orf52 CD47 CEP19 CFTR CLDN19 CLDN7 CLDN8 CLEC7A CMTM5 CSNK2B CXCL9 DEFB121 ECE2 EDDM3B EMP1 ENTPD3 FAM241B FATE1 GADD45A GSK3B IGFBP5 ITM2B KLHL12 KLRG1 KTN1 MALL MARCHF2 NAGK OCLN OLFM4 OSTCP1 PAQR5 PLPP6 RIPPLY2 RPS6KA6 SEC22A SEC23B SENP2 SFTPC SLN SMCO4 TCEA2 TMEM115 TMEM140 TMEM147 TMEM182 TMEM248 TMPRSS4 TRIM69 TSPAN15 VTI1B WDR62 ZNF250 ZNF648	8 interacting genes: ARL13B GPR42 GPX8 KLRC1 LEPROTL1 MRM1 RHOA SYNE4
Entrez ID		163183	10219
HPRD ID		08776	16076
Ensembl ID		ENSG00000181392	ENSG00000139187
Uniprot IDs		Q8N205	Q96E93
PDB IDs		6R16 6WMD	3FF7
Enriched GO Terms of Interacting Partners?		Protein Binding Bicellular Tight Junction Assembly Tight Junction Organization Tight Junction Assembly Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Apicolateral Plasma Membrane Regulation Of Glycogen (starch) Synthase Activity	Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Establishment Of Epithelial Cell Apical/basal Polarity Establishment Of Epithelial Cell Polarity Telencephalon Cell Migration Establishment Or Maintenance Of Apical/basal Cell Polarity Forebrain Cell Migration Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Mitotic Cleavage Furrow Formation Inhibitory MHC Class Ib Receptor Activity Aortic Valve Formation Establishment Of Cell Polarity Positive Regulation Of Vascular Associated Smooth Muscle Contraction Endothelial Tube Lumen Extension Skeletal Muscle Satellite Cell Migration HLA-E Specific Inhibitory MHC Class Ib Receptor Activity RRNA (guanosine-2'-O-)-methyltransferase Activity Beta Selection Epithelial Tube Morphogenesis Natural Killer Cell Inhibitory Signaling Pathway CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation RRNA (guanine) Methyltransferase Activity RRNA 2'-O-methylation Receptor Localization To Non-motile Cilium Bone Trabecula Morphogenesis Formation Of Radial Glial Scaffolds Apolipoprotein A-I-mediated Signaling Pathway Establishment Or Maintenance Of Cell Polarity Roundabout Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Endothelin Forebrain Radial Glial Cell Differentiation MHC Class Ib Receptor Activity Positive Regulation Of Lipase Activity Cleavage Furrow Formation Cell Morphogenesis Apical Junction Assembly Negative Regulation Of Oxidative Phosphorylation Regulation Of Modification Of Postsynaptic Actin Cytoskeleton MHC Class I Protein Complex Binding Protein Localization To Ciliary Membrane Interneuron Migration From The Subpallium To The Cortex Neural Tube Patterning Negative Regulation Of Cell Size Ossification Involved In Bone Maturation Negative Regulation Of Cellular Respiration Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Protein Antigen Binding
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