NASP and H1-2

Number of citations of the paper that reports this interaction (PubMedID 10893414)
0

Data Source:
HPRD (in vitro)

		NASP	H1-2
Description		nuclear autoantigenic sperm protein	H1.2 linker histone, cluster member
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Protein-containing Complex	Chromatin Nucleosome Euchromatin Nucleus Chromosome
	Molecular Function	Protein Binding Histone Binding Protein-containing Complex Binding	DNA Binding Double-stranded DNA Binding RNA Binding Protein Binding Structural Constituent Of Chromatin Chromatin DNA Binding Nucleosomal DNA Binding Histone H3K27me3 Reader Activity
	Biological Process	Blastocyst Development DNA Replication Nucleosome Assembly DNA Replication-dependent Chromatin Assembly Male Gonad Development Protein Transport Response To Testosterone CENP-A Containing Chromatin Assembly	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Nucleosome Assembly Regulation Of Transcription By RNA Polymerase II Chromosome Condensation Negative Regulation Of DNA Recombination Facultative Heterochromatin Formation
Pathways			Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS		Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		23 interacting genes: CDC42 FXR2 H1-1 H1-2 H3-3B H3-4 H3-5 H3C10 H3C13 H3C14 H3C4 H3C8 HDAC6 ITSN1 LUC7L2 MTNR1A OGT PTK2 ST3GAL3 TERF2 TERF2IP TIAM1 ULK2	31 interacting genes: AEBP2 APP ATM CDC73 CEBPA CSNK2A2 CTNNB1 CTR9 CUL4A DDB1 F10 H3C1 IL7R IRAK4 ITCH KPNA7 KPNB1 LEO1 MRE11 NASP NCL NSD1 PAF1 PARP1 POLR2A PRKCA PRKDC PUF60 SNCA VHL WDR12
Entrez ID		4678	3006
HPRD ID		04423	07514
Ensembl ID		ENSG00000132780	ENSG00000187837
Uniprot IDs		P49321 Q5T626	P16403
PDB IDs		7V1K 7V1L 7V1M 7V6P 7V6Q	8H0V 8H0W 8KE0
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Chromatin Nucleosome Nucleosome Assembly Nucleosome Organization Protein-DNA Complex Assembly Chromosome Protein-containing Complex Organization Protein Heterodimerization Activity Protein-containing Complex Assembly Cellular Component Assembly Chromatin Organization Chromatin Remodeling Chromosome Organization Telomere Organization Nucleosomal DNA Binding Negative Regulation Of DNA Recombination Epigenetic Regulation Of Gene Expression Negative Regulation Of DNA Recombination At Telomere Regulation Of Cellular Component Organization Shelterin Complex Organelle Organization Negative Regulation Of Cellular Component Organization Negative Regulation Of DNA Metabolic Process DNA Binding Regulation Of DNA Recombination Protection From Non-homologous End Joining At Telomere Gene Expression Protein-containing Complex Macromolecule Biosynthetic Process Nuclear Telomere Cap Complex Mitophagy Euchromatin Nucleus G-rich Strand Telomeric DNA Binding Chromosome, Telomeric Region Protein Localization To Chromosome, Telomeric Region Nucleoplasm Telomere Capping Autophagy Of Mitochondrion Telomere Maintenance In Response To DNA Damage Negative Regulation Of Chromosome Organization Regulation Of Cell Growth Chromatin DNA Binding Collateral Sprouting Dendritic Spine Morphogenesis Positive Regulation Of Cellular Component Organization RNA-templated DNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Telomeric DNA Binding Negative Regulation Of Protein-containing Complex Assembly	Nucleoplasm Endodermal Cell Fate Commitment Cell Fate Commitment Involved In Formation Of Primary Germ Layer Positive Regulation Of Macromolecule Metabolic Process Nucleus Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Cdc73/Paf1 Complex Negative Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Chromatin Organization Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Macromolecule Metabolic Process Regulation Of Immune System Process Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of Hemopoiesis Protein-containing Complex Regulation Of Myeloid Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Myeloid Cell Differentiation Transcription Elongation By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription Elongation Negative Regulation Of Biosynthetic Process Regulation Of Apoptotic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death Stem Cell Population Maintenance Regulation Of RNA Metabolic Process Maintenance Of Cell Number Positive Regulation Of RNA Metabolic Process Regulation Of Cell Differentiation Negative Regulation Of Apoptotic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of Programmed Cell Death Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Enzyme Binding Cell Surface Receptor Signaling Pathway Wnt Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II
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