H1-2 and LEO1

Number of citations of the paper that reports this interaction (PubMedID 24360965)
45

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		H1-2	LEO1
Description		H1.2 linker histone, cluster member	LEO1 component of Paf1/RNA polymerase II complex
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GO Annotations	Cellular Component	Chromatin Nucleosome Euchromatin Nucleus Chromosome	Fibrillar Center Nucleus Nucleoplasm Centrosome Cdc73/Paf1 Complex
	Molecular Function	DNA Binding Double-stranded DNA Binding RNA Binding Protein Binding Structural Constituent Of Chromatin Chromatin DNA Binding Nucleosomal DNA Binding Histone H3K27me3 Reader Activity	Protein Binding RNA Polymerase II C-terminal Domain Phosphoserine Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Nucleosome Assembly Regulation Of Transcription By RNA Polymerase II Chromosome Condensation Negative Regulation Of DNA Recombination Facultative Heterochromatin Formation	Endodermal Cell Fate Commitment Transcription Elongation By RNA Polymerase II Wnt Signaling Pathway Stem Cell Population Maintenance MRNA 3'-end Processing Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)	Formation of RNA Pol II elongation complex Formation of the beta-catenin:TCF transactivating complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS			Frailty index ( 34431594)
Interacting Genes		31 interacting genes: AEBP2 APP ATM CDC73 CEBPA CSNK2A2 CTNNB1 CTR9 CUL4A DDB1 F10 H3C1 IL7R IRAK4 ITCH KPNA7 KPNB1 LEO1 MRE11 NASP NCL NSD1 PAF1 PARP1 POLR2A PRKCA PRKDC PUF60 SNCA VHL WDR12	9 interacting genes: CSNK2A1 CTNNB1 DYRK1A ERCC6 GPRASP3 H1-2 POLR2A TCEA1 TCEA3
Entrez ID		3006	123169
HPRD ID		07514	11231
Ensembl ID		ENSG00000187837	ENSG00000166477
Uniprot IDs		P16403	Q8WVC0
PDB IDs		8H0V 8H0W 8KE0	4M6T 6GMH 6TED 7OOP 7OPC 7OPD 7UNC 7UND 8A3Y 9EGX 9EGY 9EGZ 9EH0 9EH2
Enriched GO Terms of Interacting Partners?		Nucleoplasm Endodermal Cell Fate Commitment Cell Fate Commitment Involved In Formation Of Primary Germ Layer Positive Regulation Of Macromolecule Metabolic Process Nucleus Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Cdc73/Paf1 Complex Negative Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Chromatin Organization Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Macromolecule Metabolic Process Regulation Of Immune System Process Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of Hemopoiesis Protein-containing Complex Regulation Of Myeloid Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Myeloid Cell Differentiation Transcription Elongation By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription Elongation Negative Regulation Of Biosynthetic Process Regulation Of Apoptotic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death Stem Cell Population Maintenance Regulation Of RNA Metabolic Process Maintenance Of Cell Number Positive Regulation Of RNA Metabolic Process Regulation Of Cell Differentiation Negative Regulation Of Apoptotic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of Programmed Cell Death Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Enzyme Binding Cell Surface Receptor Signaling Pathway Wnt Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II	DNA-templated Transcription Elongation DNA-templated Transcription Transcription Elongation By RNA Polymerase II Double-strand Break Repair Via Nonhomologous End Joining Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleic Acid Metabolic Process Transcription By RNA Polymerase II Double-strand Break Repair Via Classical Nonhomologous End Joining Regulation Of RNA Metabolic Process RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleobase-containing Compound Biosynthetic Process Regulation Of DNA Recombination Negative Regulation Of DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of DNA Metabolic Process Nucleus Double-strand Break Repair Negative Regulation Of DNA Repair Regulation Of Gene Expression Negative Regulation Of Double-strand Break Repair Positive Regulation Of RNA Splicing Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of DNA Recombination Macromolecule Biosynthetic Process Euchromatin Negative Regulation Of Nucleobase-containing Compound Metabolic Process Glial Cell Fate Determination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Positive Regulation Of DNA-templated Transcription, Elongation Histone H3T45 Kinase Activity Negative Regulation Of Cell Cycle Regulation Of Macromolecule Metabolic Process Regulation Of Double-strand Break Repair Via Homologous Recombination Mesenchymal Stem Cell Differentiation Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Beta-catenin-ICAT Complex Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Renal Outer Medulla Development Renal Vesicle Formation Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Branching Involved In Lung Morphogenesis Neural Plate Development
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