H1-2 and MRE11

Number of citations of the paper that reports this interaction (PubMedID 29844578)
64

Data Source:
BioGRID (affinity chromatography technology, pull down)

		H1-2	MRE11
Description		H1.2 linker histone, cluster member	MRE11 double strand break repair nuclease
Image
GO Annotations	Cellular Component	Chromatin Nucleosome Euchromatin Nucleus Chromosome	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Chromosome Cytoplasm Cytosol PML Body Mre11 Complex Site Of Double-strand Break BRCA1-C Complex Chromosomal Region
	Molecular Function	DNA Binding Double-stranded DNA Binding RNA Binding Protein Binding Structural Constituent Of Chromatin Chromatin DNA Binding Nucleosomal DNA Binding Histone H3K27me3 Reader Activity	Single-stranded DNA Endodeoxyribonuclease Activity DNA Binding DNA Helicase Activity Double-stranded DNA Binding Nuclease Activity Endonuclease Activity DNA Endonuclease Activity Exonuclease Activity Protein Binding 3'-5'-DNA Exonuclease Activity 3'-5' Exonuclease Activity Hydrolase Activity Manganese Ion Binding Identical Protein Binding Cadherin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Nucleosome Assembly Regulation Of Transcription By RNA Polymerase II Chromosome Condensation Negative Regulation Of DNA Recombination Facultative Heterochromatin Formation	Regulation Of Mitotic Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Damage Response Telomere Maintenance Via Telomerase Sister Chromatid Cohesion Mitotic G2 DNA Damage Checkpoint Signaling Homologous Chromosome Pairing At Meiosis Reciprocal Meiotic Recombination Cell Population Proliferation Mitotic Intra-S DNA Damage Checkpoint Signaling Telomeric 3' Overhang Formation Positive Regulation Of Telomere Maintenance Homologous Recombination Meiotic DNA Double-strand Break Formation Negative Regulation Of Apoptotic Process Mitotic G2/M Transition Checkpoint Chromosome Organization Meiotic Cell Cycle R-loop Processing Mitochondrial Double-strand Break Repair Via Homologous Recombination DNA Strand Resection Involved In Replication Fork Processing Positive Regulation Of Double-strand Break Repair Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)	Cytosolic sensors of pathogen-associated DNA DNA Damage/Telomere Stress Induced Senescence IRF3-mediated induction of type I IFN HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2
Drugs
Diseases			Ataxia with ocular apraxia (AOA), including: Ataxia telangiectasia (AT); Ataxia telangiectasia like disorder (ATLD); Ataxia oculomotor apraxia type 1 (AOA1); Ataxia oculomotor apraxia type 2 (AOA2) DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS
Interacting Genes		31 interacting genes: AEBP2 APP ATM CDC73 CEBPA CSNK2A2 CTNNB1 CTR9 CUL4A DDB1 F10 H3C1 IL7R IRAK4 ITCH KPNA7 KPNB1 LEO1 MRE11 NASP NCL NSD1 PAF1 PARP1 POLR2A PRKCA PRKDC PUF60 SNCA VHL WDR12	35 interacting genes: - ATM ATR CCNE1 CDK2 CDX2 CEBPA CXCR5 DCLRE1C DYNC1H1 DYNLL1 ENDOD1 EP300 FANCD2 GPR83 GRB2 H1-2 H2AX H4C1 JRKL LIG1 LOX MAPK8IP2 MLF2 NBN NEK1 NKX3-1 PRKDC RAD50 RECQL5 SPOP SUMO1 SUMO2 TMEM126A XRCC6
Entrez ID		3006	4361
HPRD ID		07514	02889
Ensembl ID		ENSG00000187837	ENSG00000020922
Uniprot IDs		P16403	F8W7U8 P49959 Q05D78
PDB IDs		8H0V 8H0W 8KE0	3T1I 7ZQY 8BAH 8K00
Enriched GO Terms of Interacting Partners?		Nucleoplasm Endodermal Cell Fate Commitment Cell Fate Commitment Involved In Formation Of Primary Germ Layer Positive Regulation Of Macromolecule Metabolic Process Nucleus Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Cdc73/Paf1 Complex Negative Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Chromatin Organization Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Macromolecule Metabolic Process Regulation Of Immune System Process Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of Hemopoiesis Protein-containing Complex Regulation Of Myeloid Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Myeloid Cell Differentiation Transcription Elongation By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription Elongation Negative Regulation Of Biosynthetic Process Regulation Of Apoptotic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death Stem Cell Population Maintenance Regulation Of RNA Metabolic Process Maintenance Of Cell Number Positive Regulation Of RNA Metabolic Process Regulation Of Cell Differentiation Negative Regulation Of Apoptotic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of Programmed Cell Death Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Enzyme Binding Cell Surface Receptor Signaling Pathway Wnt Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II	DNA Damage Response Telomere Organization DNA Metabolic Process Telomere Maintenance Chromosome Organization DNA Repair Double-strand Break Repair DNA Strand Resection Involved In Replication Fork Processing Chromosome, Telomeric Region Cellular Response To Stress Response To Ionizing Radiation Signal Transduction In Response To DNA Damage DNA Recombination DNA Damage Checkpoint Signaling Protein Localization To Chromosome Histone H2AXS139 Kinase Activity Organelle Organization Negative Regulation Of DNA Metabolic Process Nucleic Acid Metabolic Process Recombinational Repair Negative Regulation Of Cell Cycle Phase Transition Regulation Of Double-strand Break Repair Negative Regulation Of Cell Cycle Somatic Cell DNA Recombination Regulation Of DNA Metabolic Process V(D)J Recombination Negative Regulation Of Cell Cycle Process Chromosome Response To Gamma Radiation Regulation Of Cell Cycle Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Cell Cycle Process Response To Radiation Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Protein Localization To Site Of Double-strand Break Damaged DNA Binding Mitotic DNA Damage Checkpoint Signaling Double-strand Break Repair Via Homologous Recombination Response To Stress Mitotic DNA Integrity Checkpoint Signaling Regulation Of DNA Recombination Regulation Of DNA Repair Nucleobase-containing Compound Metabolic Process Negative Regulation Of Telomere Capping Nonhomologous End Joining Complex Chromatin Remodeling Regulation Of Mitotic Cell Cycle
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