H1-2 and AEBP2

Number of citations of the paper that reports this interaction (PubMedID 16431907)
0

Data Source:
BioGRID (pull down)

		H1-2	AEBP2
Description		H1.2 linker histone, cluster member	AE binding protein 2
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GO Annotations	Cellular Component	Chromatin Nucleosome Euchromatin Nucleus Chromosome	Chromatin Nucleus Nucleoplasm ESC/E(Z) Complex
	Molecular Function	DNA Binding Double-stranded DNA Binding RNA Binding Protein Binding Structural Constituent Of Chromatin Chromatin DNA Binding Nucleosomal DNA Binding Histone H3K27me3 Reader Activity	DNA Binding Transcription Coregulator Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Nucleosome Assembly Regulation Of Transcription By RNA Polymerase II Chromosome Condensation Negative Regulation Of DNA Recombination Facultative Heterochromatin Formation	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways		Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)	PRC2 methylates histones and DNA PKMTs methylate histone lysines
Drugs
Diseases
GWAS			Body size at age 10 ( 32376654) Chronic mountain sickness ( 31417607) Diastolic blood pressure ( 30224653) Diverticular disease ( 30177863) Height ( 28552196) Lung function (FEV1/FVC) ( 30804560) Manganese levels ( 26025379) Obesity-related traits ( 23251661) Opioid use cessation ( 31936517) Pulmonary function ( 21946350) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Schizophrenia, bipolar disorder or major depressive disorder ( 34099189)
Interacting Genes		31 interacting genes: AEBP2 APP ATM CDC73 CEBPA CSNK2A2 CTNNB1 CTR9 CUL4A DDB1 F10 H3C1 IL7R IRAK4 ITCH KPNA7 KPNB1 LEO1 MRE11 NASP NCL NSD1 PAF1 PARP1 POLR2A PRKCA PRKDC PUF60 SNCA VHL WDR12	18 interacting genes: APP EED H1-1 H1-2 HMBOX1 JMJD6 KRTAP10-8 LDOC1 MDFI PICK1 RALYL RBBP4 SUZ12 THAP1 TRIM55 TRIM63 TSPYL2 ZNF408
Entrez ID		3006	121536
HPRD ID		07514	16477
Ensembl ID		ENSG00000187837	ENSG00000139154
Uniprot IDs		P16403	Q6ZN18
PDB IDs		8H0V 8H0W 8KE0	5WAI 5Y0U 5Y1U 6C23 6C24 6WKR 7KSO 8EQV 8FYH 8T9G 8TAS 8TB9 8VMI 8VML 8VNV 8VNZ 9C8U 9DCH
Enriched GO Terms of Interacting Partners?		Nucleoplasm Endodermal Cell Fate Commitment Cell Fate Commitment Involved In Formation Of Primary Germ Layer Positive Regulation Of Macromolecule Metabolic Process Nucleus Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Cdc73/Paf1 Complex Negative Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Chromatin Organization Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Macromolecule Metabolic Process Regulation Of Immune System Process Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of Hemopoiesis Protein-containing Complex Regulation Of Myeloid Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Myeloid Cell Differentiation Transcription Elongation By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription Elongation Negative Regulation Of Biosynthetic Process Regulation Of Apoptotic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death Stem Cell Population Maintenance Regulation Of RNA Metabolic Process Maintenance Of Cell Number Positive Regulation Of RNA Metabolic Process Regulation Of Cell Differentiation Negative Regulation Of Apoptotic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of Programmed Cell Death Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Enzyme Binding Cell Surface Receptor Signaling Pathway Wnt Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Remodeling Identical Protein Binding Facultative Heterochromatin Formation ESC/E(Z) Complex Chromatin Organization Protein-DNA Complex Assembly Negative Regulation Of Transcription By RNA Polymerase II Nucleosome Assembly Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Nucleosomal DNA Binding Nucleosome Organization Negative Regulation Of Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Receptor-mediated Endocytosis Sex Chromatin Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Chromatin Silencing Complex Negative Regulation Of Macromolecule Metabolic Process Chromatin DNA Binding Regulation Of Primary Metabolic Process Epigenetic Regulation Of Gene Expression Protein-containing Complex Assembly Regulation Of Receptor-mediated Endocytosis Protein-containing Complex Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of Receptor Internalization Heterochromatin Formation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromosome Chromatin Positive Regulation Of Endocytosis Chromosome Condensation Negative Regulation Of Gene Expression, Epigenetic Amyloid-beta Complex Growth Cone Lamellipodium Neuron Projection Organization Regulation Of RNA Metabolic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Oligodendrocyte Differentiation Histone H4R3 Demethylase Activity Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Peptidyl-lysine 5-dioxygenase Activity
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