MSN and ICAM1

Number of citations of the paper that reports this interaction (PubMedID 12082081)
52

Data Source:
HPRD (in vitro, in vivo)

		MSN	ICAM1
Description		moesin	intercellular adhesion molecule 1
Image
GO Annotations	Cellular Component	Uropod Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Microvillus Adherens Junction Focal Adhesion Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Filopodium Pseudopodium Microvillus Membrane Vesicle Cell Projection Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Blood Microparticle	Immunological Synapse Extracellular Space Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Extracellular Matrix Membrane Raft Extracellular Exosome
	Molecular Function	Double-stranded RNA Binding Actin Binding Signaling Receptor Binding Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Enzyme Binding Protein Kinase Binding Cell Adhesion Molecule Binding	Virus Receptor Activity Transmembrane Signaling Receptor Activity Integrin Binding Protein Binding Signaling Receptor Activity
	Biological Process	Immunological Synapse Formation Cytoskeleton Organization Leukocyte Cell-cell Adhesion Regulation Of Cell Shape Regulation Of Cell Size Positive Regulation Of Gene Expression Gland Morphogenesis Membrane To Membrane Docking T Cell Proliferation Establishment Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Protein Catabolic Process Leukocyte Migration Establishment Of Endothelial Barrier T Cell Aggregation Positive Regulation Of Podosome Assembly T Cell Migration Regulation Of Organelle Assembly Positive Regulation Of Protein Localization To Early Endosome Regulation Of Lymphocyte Migration Positive Regulation Of Early Endosome To Late Endosome Transport	Regulation Of Leukocyte Mediated Cytotoxicity Immune Effector Process T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell T Cell Antigen Processing And Presentation Positive Regulation Of Cellular Extravasation Immune Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Membrane To Membrane Docking Cell Adhesion Mediated By Integrin Adhesion Of Symbiont To Host Symbiont Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Leukocyte Migration Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Glucose Stimulus T Cell Extravasation Cell-cell Adhesion Regulation Of Ruffle Assembly Cellular Response To Oxygen-containing Compound Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cellular Response To Amyloid-beta Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Recycling pathway of L1 Recycling pathway of L1 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea Signaling by ALK fusions and activated point mutants	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling
Drugs			Natalizumab Hyaluronic acid Nafamostat
Diseases			Allograft rejection
GWAS		Male-pattern baldness ( 28196072)	Blood protein levels ( 30072576) Crohn's disease ( 21102463) Height ( 31562340) Inflammatory bowel disease ( 23128233) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low white blood cell count (conditioned on rs2814778) ( 29596498) Lymphocyte count ( 27863252 32888494) Monocyte count ( 32888494) Pulse pressure ( 27841878) Soluble ICAM-1 ( 18604267 21533024 31217265) White blood cell count ( 32888494)
Interacting Genes		33 interacting genes: BCAP31 CD46 CD93 CDK11B CEBPA CFC1 ERBB2 EZR ICAM1 ICAM2 ICAM3 L1CAM LINC01554 LMO2 MYBPC2 NCF1 NCF4 NHERF1 PLEC PPM1A PPM1B PRKAR2A PRKCQ ROCK1 SELL SELPLG SMURF1 SPN TERF1 TRIM15 TSC1 VCAM1 VPS11	28 interacting genes: BCL7B BRAF CALR CYSRT1 EGFR EZR FANCF FGG HDAC1 HSD3B7 IL2RA IL2RG ITGAL ITGAM ITGB2 KEAP1 KIF1A KRTAP10-8 MAP2K7 MC1R MSN MTPN MYO1F SLC3A2 SLCO2B1 SPN TBL3 UBQLN2
Entrez ID		4478	3383
HPRD ID		02399	00996
Ensembl ID		ENSG00000147065	ENSG00000090339
Uniprot IDs		P26038 V9HWC0	A0A384MEK5 P05362
PDB IDs		1E5W 1EF1 1SGH 6TXQ 6TXS 8CIR 8CIS 8CIT 8CIU	1D3E 1D3I 1D3L 1IAM 1IC1 1MQ8 1P53 1Z7Z 2OZ4 3TCX 5MZA 6EIT 6S8U 7BG7
Enriched GO Terms of Interacting Partners?		Leukocyte Cell-cell Adhesion Membrane To Membrane Docking Leukocyte Tethering Or Rolling Leukocyte Adhesion To Vascular Endothelial Cell Cell-cell Adhesion Cell Adhesion Uropod Plasma Membrane Microvillus Membrane Docking Immune System Process Negative Regulation Of Signal Transduction Leukocyte Activation Negative Regulation Of Cell Communication Negative Regulation Of Signaling Focal Adhesion Phagolysosome N-terminal Protein Myristoylation Regulation Of T Cell Proliferation Cell Activation Membrane Cell Migration Cell Periphery Positive Regulation Of Cell Adhesion Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Plasma Membrane Raft Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of T Cell Proliferation Activin Receptor Binding Protein Domain Specific Binding Protein Localization To Cell Periphery Leukocyte Migration Microvillus Assembly Negative Regulation Of Intracellular Signal Transduction Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Immunological Synapse Microvillus Organization Regulation Of Mononuclear Cell Proliferation Cell Motility Superoxide-generating NADPH Oxidase Activator Activity Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Intracellular Transport Regulation Of Leukocyte Proliferation Integrin Binding Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Cell Surface Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Lymphocyte Activation	Cell Surface Leukocyte Cell-cell Adhesion Regulation Of Vesicle-mediated Transport Cell Adhesion Molecule Binding Cell Activation External Side Of Plasma Membrane Cell-cell Adhesion Uropod Leukocyte Activation Integrin AlphaL-beta2 Complex Integrin AlphaM-beta2 Complex Microvillus Cell-substrate Adhesion Cell Adhesion T Cell Activation Interleukin-2 Binding Interleukin-2 Receptor Activity ICAM-3 Receptor Activity Positive Regulation Of Neutrophil Degranulation Integrin Complex Positive Regulation Of Cell Adhesion Gland Morphogenesis Negative Regulation Of Dopamine Metabolic Process Positive Regulation Of Metabolic Process Cell-matrix Adhesion Plasma Membrane Raft Negative Regulation Of Catecholamine Metabolic Process Membrane To Membrane Docking Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Transport Regulation Of Developmental Process Basolateral Plasma Membrane Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Neutrophil Degranulation Regulation Of Multicellular Organismal Process Lymphocyte Activation Regulation Of ERK1 And ERK2 Cascade Lymphocyte Migration Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Localization To Early Endosome Regulation Of Immune System Process Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Macromolecule Metabolic Process Complement Component C3b Binding Heat Shock Protein Binding Basal Plasma Membrane Interleukin-2-mediated Signaling Pathway Positive Regulation Of Protein Localization To Endosome Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Adhesion
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