ICAM1 and BCL7B

		ICAM1	BCL7B
Description		intercellular adhesion molecule 1	BAF chromatin remodeling complex subunit BCL7B
Image			No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Extracellular Space Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Extracellular Matrix Membrane Raft Extracellular Exosome	Chromatin Nucleoplasm SWI/SNF Complex GBAF Complex
	Molecular Function	Virus Receptor Activity Transmembrane Signaling Receptor Activity Integrin Binding Protein Binding Signaling Receptor Activity	Actin Binding Protein Binding
	Biological Process	Regulation Of Leukocyte Mediated Cytotoxicity Immune Effector Process T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell T Cell Antigen Processing And Presentation Positive Regulation Of Cellular Extravasation Immune Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Membrane To Membrane Docking Cell Adhesion Mediated By Integrin Adhesion Of Symbiont To Host Symbiont Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Leukocyte Migration Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Glucose Stimulus T Cell Extravasation Cell-cell Adhesion Regulation Of Ruffle Assembly Cellular Response To Oxygen-containing Compound Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cellular Response To Amyloid-beta Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Endothelial Cell Apoptotic Process	Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Apoptotic Process Positive Regulation Of Cell Population Proliferation Wnt Signaling Pathway Regulation Of Mitotic Metaphase/anaphase Transition Cell Differentiation Negative Regulation Of Cell Differentiation Regulation Of G0 To G1 Transition Positive Regulation Of Stem Cell Population Maintenance Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling	Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
Drugs		Natalizumab Hyaluronic acid Nafamostat
Diseases		Allograft rejection
GWAS		Blood protein levels ( 30072576) Crohn's disease ( 21102463) Height ( 31562340) Inflammatory bowel disease ( 23128233) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low white blood cell count (conditioned on rs2814778) ( 29596498) Lymphocyte count ( 27863252 32888494) Monocyte count ( 32888494) Pulse pressure ( 27841878) Soluble ICAM-1 ( 18604267 21533024 31217265) White blood cell count ( 32888494)	C-reactive protein levels ( 21300955 30388399) Diastolic blood pressure ( 27841878) Hypertriglyceridemia ( 23505323) Lamb consumption ( 32066663) Liver enzyme levels (alkaline phosphatase) ( 33972514) Malaria ( 31844061) Meat-related diet ( 32066663) Non-oily fish consumption ( 32066663) Red cell distribution width ( 32888494) Triglycerides ( 18193044 20864672) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		28 interacting genes: BCL7B BRAF CALR CYSRT1 EGFR EZR FANCF FGG HDAC1 HSD3B7 IL2RA IL2RG ITGAL ITGAM ITGB2 KEAP1 KIF1A KRTAP10-8 MAP2K7 MC1R MSN MTPN MYO1F SLC3A2 SLCO2B1 SPN TBL3 UBQLN2	5 interacting genes: ICAM1 MAGEA3 MAGEA6 TERF1 TERF2IP
Entrez ID		3383	9275
HPRD ID		00996	05786
Ensembl ID		ENSG00000090339	ENSG00000106635
Uniprot IDs		A0A384MEK5 P05362	F2Z3H6 Q9BQE9
PDB IDs		1D3E 1D3I 1D3L 1IAM 1IC1 1MQ8 1P53 1Z7Z 2OZ4 3TCX 5MZA 6EIT 6S8U 7BG7
Enriched GO Terms of Interacting Partners?		Cell Surface Leukocyte Cell-cell Adhesion Regulation Of Vesicle-mediated Transport Cell Adhesion Molecule Binding Cell Activation External Side Of Plasma Membrane Cell-cell Adhesion Uropod Leukocyte Activation Integrin AlphaL-beta2 Complex Integrin AlphaM-beta2 Complex Microvillus Cell-substrate Adhesion Cell Adhesion T Cell Activation Interleukin-2 Binding Interleukin-2 Receptor Activity ICAM-3 Receptor Activity Positive Regulation Of Neutrophil Degranulation Integrin Complex Positive Regulation Of Cell Adhesion Gland Morphogenesis Negative Regulation Of Dopamine Metabolic Process Positive Regulation Of Metabolic Process Cell-matrix Adhesion Plasma Membrane Raft Negative Regulation Of Catecholamine Metabolic Process Membrane To Membrane Docking Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Transport Regulation Of Developmental Process Basolateral Plasma Membrane Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Neutrophil Degranulation Regulation Of Multicellular Organismal Process Lymphocyte Activation Regulation Of ERK1 And ERK2 Cascade Lymphocyte Migration Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Localization To Early Endosome Regulation Of Immune System Process Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Macromolecule Metabolic Process Complement Component C3b Binding Heat Shock Protein Binding Basal Plasma Membrane Interleukin-2-mediated Signaling Pathway Positive Regulation Of Protein Localization To Endosome Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Adhesion	Nuclear Telomere Cap Complex Shelterin Complex G-rich Strand Telomeric DNA Binding Telomere Capping Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Telomere Maintenance DNA Biosynthetic Process Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Negative Regulation Of Chromosome Organization Positive Regulation Of Shelterin Complex Assembly Telomere Maintenance Negative Regulation Of Autophagy Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Histone Deacetylase Binding Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomere Organization Negative Regulation Of DNA Recombination At Telomere Negative Regulation Of DNA Metabolic Process Chromosome, Telomeric Region T Cell Antigen Processing And Presentation Membrane To Membrane Docking T Cell Extravasation Negative Regulation Of Apoptotic Signaling Pathway Receptor-mediated Virion Attachment To Host Cell Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Establishment Of Protein Localization To Telomere Telomerase Activity Regulation Of Chromosome Organization Ankyrin Repeat Binding Protection From Non-homologous End Joining At Telomere Negative Regulation Of Macromolecule Metabolic Process T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Positive Regulation Of DNA Metabolic Process Telomere Localization Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding Negative Regulation Of Metabolic Process Virion Attachment To Host Cell Telomeric Loop Disassembly
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