ICAM1 and IL2RG

Number of citations of the paper that reports this interaction (PubMedID 1976256)
33

Data Source:
HPRD (in vivo)

		ICAM1	IL2RG
Description		intercellular adhesion molecule 1	interleukin 2 receptor subunit gamma
Image
GO Annotations	Cellular Component	Immunological Synapse Extracellular Space Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Extracellular Matrix Membrane Raft Extracellular Exosome	Nucleoplasm Endosome Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Receptor Complex
	Molecular Function	Virus Receptor Activity Transmembrane Signaling Receptor Activity Integrin Binding Protein Binding Signaling Receptor Activity	Cytokine Receptor Activity Interleukin-2 Receptor Activity Interleukin-4 Receptor Activity Interleukin-7 Receptor Activity Protein Binding Coreceptor Activity Cytokine Binding Interleukin-2 Binding Interleukin-15 Receptor Activity
	Biological Process	Regulation Of Leukocyte Mediated Cytotoxicity Immune Effector Process T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell T Cell Antigen Processing And Presentation Positive Regulation Of Cellular Extravasation Immune Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Membrane To Membrane Docking Cell Adhesion Mediated By Integrin Adhesion Of Symbiont To Host Symbiont Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Leukocyte Migration Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Glucose Stimulus T Cell Extravasation Cell-cell Adhesion Regulation Of Ruffle Assembly Cellular Response To Oxygen-containing Compound Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cellular Response To Amyloid-beta Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Endothelial Cell Apoptotic Process	Mature B Cell Differentiation CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Immune System Process Positive Regulation Of Immunoglobulin Production Immune Response Signal Transduction Gene Expression Regulation Of Gene Expression Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Cellular Homeostasis Lymphocyte Differentiation B Cell Differentiation Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation T Cell Differentiation In Thymus Positive Regulation Of T Cell Differentiation In Thymus Interleukin-15-mediated Signaling Pathway Interleukin-4-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Positive Regulation Of B Cell Differentiation Positive Regulation Of Phagocytosis
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling	Interleukin-7 signaling Interleukin-7 signaling RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-21 signaling Interleukin receptor SHC signaling STAT3 nuclear events downstream of ALK signaling
Drugs		Natalizumab Hyaluronic acid Nafamostat	Denileukin diftitox Aldesleukin Resatorvid
Diseases		Allograft rejection	T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS		Blood protein levels ( 30072576) Crohn's disease ( 21102463) Height ( 31562340) Inflammatory bowel disease ( 23128233) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low white blood cell count (conditioned on rs2814778) ( 29596498) Lymphocyte count ( 27863252 32888494) Monocyte count ( 32888494) Pulse pressure ( 27841878) Soluble ICAM-1 ( 18604267 21533024 31217265) White blood cell count ( 32888494)
Interacting Genes		28 interacting genes: BCL7B BRAF CALR CYSRT1 EGFR EZR FANCF FGG HDAC1 HSD3B7 IL2RA IL2RG ITGAL ITGAM ITGB2 KEAP1 KIF1A KRTAP10-8 MAP2K7 MC1R MSN MTPN MYO1F SLC3A2 SLCO2B1 SPN TBL3 UBQLN2	27 interacting genes: AXL CAPNS1 ERRFI1 ICAM1 IL15 IL15RA IL2 IL2RB IL4 IL4R IL7 IL7R IL9R JAK1 JAK3 KRTAP10-3 KRTAP10-8 KRTAP5-7 NOTCH2NLA PTPRJ SHB SHC1 STAT1 STAT5A STK4 WWP1 WWP2
Entrez ID		3383	3561
HPRD ID		00996	02391
Ensembl ID		ENSG00000090339	ENSG00000147168
Uniprot IDs		A0A384MEK5 P05362	H0Y8J6 P31785
PDB IDs		1D3E 1D3I 1D3L 1IAM 1IC1 1MQ8 1P53 1Z7Z 2OZ4 3TCX 5MZA 6EIT 6S8U 7BG7	2B5I 2ERJ 3BPL 3QAZ 3QB7 4GS7 5M5E 6OEL 7S2R 8ENT 8EPA 9JQT
Enriched GO Terms of Interacting Partners?		Cell Surface Leukocyte Cell-cell Adhesion Regulation Of Vesicle-mediated Transport Cell Adhesion Molecule Binding Cell Activation External Side Of Plasma Membrane Cell-cell Adhesion Uropod Leukocyte Activation Integrin AlphaL-beta2 Complex Integrin AlphaM-beta2 Complex Microvillus Cell-substrate Adhesion Cell Adhesion T Cell Activation Interleukin-2 Binding Interleukin-2 Receptor Activity ICAM-3 Receptor Activity Positive Regulation Of Neutrophil Degranulation Integrin Complex Positive Regulation Of Cell Adhesion Gland Morphogenesis Negative Regulation Of Dopamine Metabolic Process Positive Regulation Of Metabolic Process Cell-matrix Adhesion Plasma Membrane Raft Negative Regulation Of Catecholamine Metabolic Process Membrane To Membrane Docking Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Transport Regulation Of Developmental Process Basolateral Plasma Membrane Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Neutrophil Degranulation Regulation Of Multicellular Organismal Process Lymphocyte Activation Regulation Of ERK1 And ERK2 Cascade Lymphocyte Migration Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Localization To Early Endosome Regulation Of Immune System Process Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Macromolecule Metabolic Process Complement Component C3b Binding Heat Shock Protein Binding Basal Plasma Membrane Interleukin-2-mediated Signaling Pathway Positive Regulation Of Protein Localization To Endosome Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Adhesion	Cytokine-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Positive Regulation Of Lymphocyte Differentiation Regulation Of Lymphocyte Differentiation Lymphocyte Activation Cell Surface Receptor Signaling Pathway Interleukin-4-mediated Signaling Pathway Positive Regulation Of Leukocyte Differentiation Interleukin-9-mediated Signaling Pathway Leukocyte Activation Regulation Of Hemopoiesis Lymphocyte Differentiation Cell Activation Interleukin-2-mediated Signaling Pathway Positive Regulation Of Cell Activation Regulation Of T Cell Differentiation Cell Surface Receptor Signaling Pathway Via STAT Mononuclear Cell Differentiation Positive Regulation Of Lymphocyte Activation Regulation Of Cell Activation Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Leukocyte Differentiation Regulation Of Multicellular Organismal Development Positive Regulation Of Cell Development Positive Regulation Of T Cell Differentiation Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Adhesion Positive Regulation Of Natural Killer Cell Differentiation Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Development Positive Regulation Of Cell Differentiation Regulation Of Cell-cell Adhesion Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of T Cell Activation Regulation Of Natural Killer Cell Differentiation Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Signal Transduction Cytokine Receptor Activity Regulation Of T-helper Cell Differentiation Positive Regulation Of Immune System Process B Cell Activation Regulation Of Cell Differentiation Regulation Of Cytokine Production Immune System Process Natural Killer Cell Differentiation Regulation Of Immune System Process Natural Killer Cell Activation
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