MSN and NCF4

Number of citations of the paper that reports this interaction (PubMedID 11716484)
0

Data Source:
HPRD (in vitro, in vivo)

		MSN	NCF4
Description		moesin	neutrophil cytosolic factor 4
Image
GO Annotations	Cellular Component	Uropod Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Microvillus Adherens Junction Focal Adhesion Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Filopodium Pseudopodium Microvillus Membrane Vesicle Cell Projection Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Blood Microparticle	Cytoplasm Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Phagolysosome NADPH Oxidase Complex
	Molecular Function	Double-stranded RNA Binding Actin Binding Signaling Receptor Binding Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Enzyme Binding Protein Kinase Binding Cell Adhesion Molecule Binding	Protein Binding Lipid Binding Superoxide-generating NADPH Oxidase Activator Activity Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding
	Biological Process	Immunological Synapse Formation Cytoskeleton Organization Leukocyte Cell-cell Adhesion Regulation Of Cell Shape Regulation Of Cell Size Positive Regulation Of Gene Expression Gland Morphogenesis Membrane To Membrane Docking T Cell Proliferation Establishment Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Protein Catabolic Process Leukocyte Migration Establishment Of Endothelial Barrier T Cell Aggregation Positive Regulation Of Podosome Assembly T Cell Migration Regulation Of Organelle Assembly Positive Regulation Of Protein Localization To Early Endosome Regulation Of Lymphocyte Migration Positive Regulation Of Early Endosome To Late Endosome Transport	Phagocytosis Superoxide Anion Generation Respiratory Burst
Pathways		Recycling pathway of L1 Recycling pathway of L1 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea Signaling by ALK fusions and activated point mutants	ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle
Drugs			Dextromethorphan
Diseases
GWAS		Male-pattern baldness ( 28196072)	Allergic disease (asthma, hay fever or eczema) ( 29679657) Asthma ( 32296059) Atopic dermatitis ( 22197932) Crohn's disease ( 28067908) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Inflammatory bowel disease ( 27569725) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Multiple sclerosis ( 24076602 31604244) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		33 interacting genes: BCAP31 CD46 CD93 CDK11B CEBPA CFC1 ERBB2 EZR ICAM1 ICAM2 ICAM3 L1CAM LINC01554 LMO2 MYBPC2 NCF1 NCF4 NHERF1 PLEC PPM1A PPM1B PRKAR2A PRKCQ ROCK1 SELL SELPLG SMURF1 SPN TERF1 TRIM15 TSC1 VCAM1 VPS11	11 interacting genes: CORO1A CRYAA CYBA CYBB MSN NCF1 NCF2 PRKCD PRKDC TXN XRCC6
Entrez ID		4478	4689
HPRD ID		02399	03289
Ensembl ID		ENSG00000147065	ENSG00000100365
Uniprot IDs		P26038 V9HWC0	A0A494BZS1 Q15080
PDB IDs		1E5W 1EF1 1SGH 6TXQ 6TXS 8CIR 8CIS 8CIT 8CIU	1H6H 1OEY 1W6X 1W70 1Z9Q 2DYB
Enriched GO Terms of Interacting Partners?		Leukocyte Cell-cell Adhesion Membrane To Membrane Docking Leukocyte Tethering Or Rolling Leukocyte Adhesion To Vascular Endothelial Cell Cell-cell Adhesion Cell Adhesion Uropod Plasma Membrane Microvillus Membrane Docking Immune System Process Negative Regulation Of Signal Transduction Leukocyte Activation Negative Regulation Of Cell Communication Negative Regulation Of Signaling Focal Adhesion Phagolysosome N-terminal Protein Myristoylation Regulation Of T Cell Proliferation Cell Activation Membrane Cell Migration Cell Periphery Positive Regulation Of Cell Adhesion Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Plasma Membrane Raft Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of T Cell Proliferation Activin Receptor Binding Protein Domain Specific Binding Protein Localization To Cell Periphery Leukocyte Migration Microvillus Assembly Negative Regulation Of Intracellular Signal Transduction Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Immunological Synapse Microvillus Organization Regulation Of Mononuclear Cell Proliferation Cell Motility Superoxide-generating NADPH Oxidase Activator Activity Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Intracellular Transport Regulation Of Leukocyte Proliferation Integrin Binding Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Cell Surface Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Lymphocyte Activation	Superoxide-generating NAD(P)H Oxidase Activity NADPH Oxidase Complex Respiratory Burst Superoxide Anion Generation Hydrogen Peroxide Metabolic Process Reactive Oxygen Species Metabolic Process Superoxide Metabolic Process Innate Immune Response Hydrogen Peroxide Biosynthetic Process Response To Other Organism Electron Transfer Activity Immune Response Defense Response To Symbiont Defense Response To Other Organism Immune System Process Response To Radiation Reactive Oxygen Species Biosynthetic Process Response To External Biotic Stimulus Defense Response Response To Angiotensin Cellular Response To L-glutamine Phagolysosome DNA-dependent Protein Kinase Complex Response To Gamma Radiation DNA-dependent Protein Kinase-DNA Ligase 4 Complex Response To Stress Nonhomologous End Joining Complex Regulation Of Immune System Process Superoxide-generating NADPH Oxidase Activator Activity Phagocytic Vesicle Membrane Regulation Of Intracellular Transport Response To Peptide Hormone Immunological Synapse Formation Cellular Response To Angiotensin Lymphocyte Proliferation Response To Aldosterone Cytoplasm Mononuclear Cell Proliferation Perinuclear Endoplasmic Reticulum Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation Leukocyte Proliferation Peptidyl-threonine Phosphorylation Response To Ionizing Radiation Regulation Of Defense Response Regulation Of Smooth Muscle Cell Proliferation Cellular Response To Oxygen-containing Compound Regulation Of Innate Immune Response Cellular Response To Gamma Radiation Lymphocyte Activation
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