ICAM1 and MTPN

		ICAM1	MTPN
Description		intercellular adhesion molecule 1	myotrophin
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GO Annotations	Cellular Component	Immunological Synapse Extracellular Space Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Extracellular Matrix Membrane Raft Extracellular Exosome	Nucleus Cytoplasm Cytosol F-actin Capping Protein Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Virus Receptor Activity Transmembrane Signaling Receptor Activity Integrin Binding Protein Binding Signaling Receptor Activity
	Biological Process	Regulation Of Leukocyte Mediated Cytotoxicity Immune Effector Process T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell T Cell Antigen Processing And Presentation Positive Regulation Of Cellular Extravasation Immune Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Membrane To Membrane Docking Cell Adhesion Mediated By Integrin Adhesion Of Symbiont To Host Symbiont Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Leukocyte Migration Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Glucose Stimulus T Cell Extravasation Cell-cell Adhesion Regulation Of Ruffle Assembly Cellular Response To Oxygen-containing Compound Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cellular Response To Amyloid-beta Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Endothelial Cell Apoptotic Process	Regulation Of Translation Regulation Of Cell Size Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Striated Muscle Tissue Development Neuron Differentiation Positive Regulation Of Cell Growth Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Metabolic Process Regulation Of Barbed-end Actin Filament Capping
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling
Drugs		Natalizumab Hyaluronic acid Nafamostat
Diseases		Allograft rejection
GWAS		Blood protein levels ( 30072576) Crohn's disease ( 21102463) Height ( 31562340) Inflammatory bowel disease ( 23128233) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low white blood cell count (conditioned on rs2814778) ( 29596498) Lymphocyte count ( 27863252 32888494) Monocyte count ( 32888494) Pulse pressure ( 27841878) Soluble ICAM-1 ( 18604267 21533024 31217265) White blood cell count ( 32888494)	Alcoholic chronic pancreatitis ( 28754779) Mean platelet volume ( 32888494) Platelet count ( 27863252) Platelet distribution width ( 27863252 32888494) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		28 interacting genes: BCL7B BRAF CALR CYSRT1 EGFR EZR FANCF FGG HDAC1 HSD3B7 IL2RA IL2RG ITGAL ITGAM ITGB2 KEAP1 KIF1A KRTAP10-8 MAP2K7 MC1R MSN MTPN MYO1F SLC3A2 SLCO2B1 SPN TBL3 UBQLN2	8 interacting genes: CAPZB CEBPA ICAM1 MAPK1 NFKB1 REL RELA RIPK4
Entrez ID		3383	136319
HPRD ID		00996	07574
Ensembl ID		ENSG00000090339	ENSG00000105887
Uniprot IDs		A0A384MEK5 P05362	P58546 Q69YG1
PDB IDs		1D3E 1D3I 1D3L 1IAM 1IC1 1MQ8 1P53 1Z7Z 2OZ4 3TCX 5MZA 6EIT 6S8U 7BG7	3AAA 7DF7 7DSA 7DSB
Enriched GO Terms of Interacting Partners?		Cell Surface Leukocyte Cell-cell Adhesion Regulation Of Vesicle-mediated Transport Cell Adhesion Molecule Binding Cell Activation External Side Of Plasma Membrane Cell-cell Adhesion Uropod Leukocyte Activation Integrin AlphaL-beta2 Complex Integrin AlphaM-beta2 Complex Microvillus Cell-substrate Adhesion Cell Adhesion T Cell Activation Interleukin-2 Binding Interleukin-2 Receptor Activity ICAM-3 Receptor Activity Positive Regulation Of Neutrophil Degranulation Integrin Complex Positive Regulation Of Cell Adhesion Gland Morphogenesis Negative Regulation Of Dopamine Metabolic Process Positive Regulation Of Metabolic Process Cell-matrix Adhesion Plasma Membrane Raft Negative Regulation Of Catecholamine Metabolic Process Membrane To Membrane Docking Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Transport Regulation Of Developmental Process Basolateral Plasma Membrane Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Neutrophil Degranulation Regulation Of Multicellular Organismal Process Lymphocyte Activation Regulation Of ERK1 And ERK2 Cascade Lymphocyte Migration Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Localization To Early Endosome Regulation Of Immune System Process Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Macromolecule Metabolic Process Complement Component C3b Binding Heat Shock Protein Binding Basal Plasma Membrane Interleukin-2-mediated Signaling Pathway Positive Regulation Of Protein Localization To Endosome Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Adhesion	Response To Peptide Response To Cytokine Cellular Response To Tumor Necrosis Factor Response To Tumor Necrosis Factor NF-kappaB P50/p65 Complex Non-canonical NF-kappaB Signal Transduction Cellular Response To Cytokine Stimulus Response To Nicotine NF-kappaB Complex Canonical NF-kappaB Signal Transduction Cellular Response To Nicotine Intracellular Signaling Cassette Actinin Binding Cytokine-mediated Signaling Pathway Regulation Of Inflammatory Response Cellular Response To Angiotensin Cellular Response To Interleukin-6 DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Immune System Process Sequence-specific DNA Binding Positive Regulation Of Defense Response Response To Interleukin-6 Positive Regulation Of Inflammatory Response Response To Angiotensin Inflammatory Response Response To Muscle Stretch Signal Transduction Involved In Regulation Of Gene Expression DNA-binding Transcription Factor Activity Transcription Regulator Complex Immune Response-activating Cell Surface Receptor Signaling Pathway Transcription Cis-regulatory Region Binding Negative Regulation Of Cytokine Production Involved In Inflammatory Response Response To DsRNA Gland Development Immune Response-regulating Cell Surface Receptor Signaling Pathway Transcription Coactivator Binding B Cell Receptor Signaling Pathway Response To Lipid Regulation Of Immune System Process Response To Lipopolysaccharide Regulation Of Defense Response Tumor Necrosis Factor-mediated Signaling Pathway Response To Molecule Of Bacterial Origin Positive Regulation Of MiRNA Metabolic Process Regulation Of Interleukin-12 Production Negative Regulation Of Cytokine Production RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Immune Response-activating Signaling Pathway Positive Regulation Of DNA-templated Transcription Initiation Intracellular Signal Transduction
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