FGF13 and CFLAR

		FGF13	CFLAR
Description		fibroblast growth factor 13	CASP8 and FADD like apoptosis regulator
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Microtubule Plasma Membrane Intercalated Disc Membrane Lateral Plasma Membrane Filopodium Axon Dendrite Growth Cone Sarcolemma Cell Projection Neuron Projection	Cytoplasm Cytosol Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Ripoptosome
	Molecular Function	Protein Binding Microtubule Binding Growth Factor Activity Sodium Channel Regulator Activity Transmembrane Transporter Binding Beta-tubulin Binding	Protease Binding Cysteine-type Endopeptidase Activity Death Receptor Binding Protein Binding Enzyme Activator Activity Cysteine-type Peptidase Activity Protein-containing Complex Binding
	Biological Process	MAPK Cascade Neuron Migration Sodium Ion Transport Negative Regulation Of Microtubule Depolymerization Signal Transduction Cell-cell Signaling Nervous System Development Learning Or Memory Learning Memory Hippocampus Development Cerebral Cortex Cell Migration Neurogenesis Establishment Of Neuroblast Polarity Microtubule Polymerization Negative Regulation Of Collateral Sprouting Branching Morphogenesis Of A Nerve Protein Localization To Plasma Membrane Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Inhibitory Synapse Assembly Positive Regulation Of Voltage-gated Sodium Channel Activity	Response To Hypoxia Proteolysis Apoptotic Process Skeletal Muscle Tissue Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Skeletal Muscle Atrophy Regulation Of Skeletal Muscle Satellite Cell Proliferation Skeletal Myofibril Assembly Macrophage Differentiation Cellular Response To Insulin Stimulus Response To Testosterone Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Skeletal Muscle Tissue Regeneration Positive Regulation Of Neuron Apoptotic Process Regulation Of Necroptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Hypoxia Cellular Response To Dexamethasone Stimulus Cellular Response To Nitric Oxide Positive Regulation Of Glomerular Mesangial Cell Proliferation Negative Regulation Of Myoblast Fusion Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extracellular Matrix Organization Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Hepatocyte Apoptotic Process Negative Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Hepatocyte Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Phase 0 - rapid depolarisation	TRAIL signaling
Drugs
Diseases
GWAS		Breast cancer in BRCA2 mutation carriers ( 23544012) Response to taxane treatment (paclitaxel) ( 23006423)	Appendicular lean mass ( 33097823) Rheumatoid arthritis ( 24390342 30423114) Triptolide cytotoxicity ( 26121980)
Interacting Genes		10 interacting genes: APP ARHGAP5 CFLAR FBXO7 MAPK8IP2 PLEKHF2 PRNP PSEN1 SCN8A VMP1	49 interacting genes: ATF2 BCL2L1 CAB39 CASP10 CASP2 CASP3 CASP6 CASP7 CASP8 CD28 CRYGA CUL1 DAXX DEDD DEDD2 ECE1 EEF1B2 FADD FGF13 FZD5 GAPDHS GJA1 IKBKB KCNIP3 MAP2K4 MAP2K7 MEX3B MYL1 NDUFS1 NEURL3 NFKB1 PROC PSEN2 QPCT RAF1 RBX1 RIPK1 RIPK2 RLIM RNF8 SKP1 SKP2 SMAD3 SPATS1 TNFRSF10B TRAF1 TRAF2 TRIM31 USP8
Entrez ID		2258	8837
HPRD ID		02090	04671
Ensembl ID		ENSG00000129682	ENSG00000003402
Uniprot IDs		A8K1P5 Q92913	A0A024R3Y4 A0A336TY74 B4E361 E9PAP3 O15519 Q59F61
PDB IDs		3HBW 4DCK 4JPZ	2N5R 3H11 3H13 6M6O 7DEE 7LXC 8YBX 8YD7 8YD8 8YM4 8YM5 8YM6 8YNI 8YNK 8YNL 8YNM 8YNN
Enriched GO Terms of Interacting Partners?		Neuron Projection Maintenance Regulation Of Neuron Apoptotic Process Neuron Projection Organization Regulation Of Apoptotic Signaling Pathway Astrocyte Activation Involved In Immune Response Positive Regulation Of Amyloid Fibril Formation Cellular Response To Amyloid-beta Growth Factor Receptor Binding Response To Amyloid-beta Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Regulation Of Biological Quality Learning Or Memory Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Negative Regulation Of Long-term Synaptic Potentiation Cognition Regulation Of Dendritic Spine Maintenance Intracellular Copper Ion Homeostasis Regulation Of Amyloid Fibril Formation Regulation Of Membrane Potential Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Mating Behavior Regulation Of Postsynapse Organization Astrocyte Activation Memory Regulation Of Programmed Cell Death Endoplasmic Reticulum Positive Regulation Of Glycolytic Process Negative Regulation Of Cell Communication Copper Ion Homeostasis Cellular Response To Copper Ion Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Molecular Function Activator Activity Modulation Of Chemical Synaptic Transmission Reproductive Behavior Positive Regulation Of Apoptotic Process Response To Copper Ion Early Endosome Membrane Regulation Of Synaptic Plasticity Positive Regulation Of Programmed Cell Death Positive Regulation Of ATP Metabolic Process Membrane Raft Dendritic Shaft Postsynapse Regulation Of Long-term Synaptic Potentiation Regulation Of Intracellular Signal Transduction	Apoptotic Process Cell Death Programmed Cell Death Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Extrinsic Apoptotic Signaling Pathway MAPK Cascade Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Cell Surface Receptor Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway Signal Transduction Protein Metabolic Process JNK Cascade Cysteine-type Endopeptidase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Signaling Ubiquitin Protein Ligase Binding Ripoptosome Intracellular Signaling Cassette Positive Regulation Of Neuron Apoptotic Process Proteolysis Death-inducing Signaling Complex Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Execution Phase Of Apoptosis Response To Stress Cytosol Protein Modification Process Post-translational Protein Modification Response To External Biotic Stimulus Cellular Response To Mechanical Stimulus Cellular Response To Staurosporine Death Effector Domain Binding Protein Polyubiquitination Cysteine-type Peptidase Activity Regulation Of Signal Transduction Death Receptor Binding T Cell Activation Regulation Of Intracellular Signal Transduction Protein Maturation Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Regulation Of Cytokine Production
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