CFLAR and MEX3B

Number of citations of the paper that reports this interaction (PubMedID 33469115)
44

Data Source:
BioGRID (pull down, affinity chromatography technology)

		CFLAR	MEX3B
Description		CASP8 and FADD like apoptosis regulator	mex-3 RNA binding family member B
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Ripoptosome	P-body Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protease Binding Cysteine-type Endopeptidase Activity Death Receptor Binding Protein Binding Enzyme Activator Activity Cysteine-type Peptidase Activity Protein-containing Complex Binding	Nucleic Acid Binding RNA Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Response To Hypoxia Proteolysis Apoptotic Process Skeletal Muscle Tissue Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Skeletal Muscle Atrophy Regulation Of Skeletal Muscle Satellite Cell Proliferation Skeletal Myofibril Assembly Macrophage Differentiation Cellular Response To Insulin Stimulus Response To Testosterone Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Skeletal Muscle Tissue Regeneration Positive Regulation Of Neuron Apoptotic Process Regulation Of Necroptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Hypoxia Cellular Response To Dexamethasone Stimulus Cellular Response To Nitric Oxide Positive Regulation Of Glomerular Mesangial Cell Proliferation Negative Regulation Of Myoblast Fusion Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extracellular Matrix Organization Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Hepatocyte Apoptotic Process Negative Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Hepatocyte Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Protein Phosphorylation Protein Autophosphorylation
Pathways		TRAIL signaling
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Rheumatoid arthritis ( 24390342 30423114) Triptolide cytotoxicity ( 26121980)	Height ( 31562340) Macular thickness ( 30535121) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Post-traumatic stress disorder ( 24677629) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Tourette syndrome ( 30818990)
Interacting Genes		49 interacting genes: ATF2 BCL2L1 CAB39 CASP10 CASP2 CASP3 CASP6 CASP7 CASP8 CD28 CRYGA CUL1 DAXX DEDD DEDD2 ECE1 EEF1B2 FADD FGF13 FZD5 GAPDHS GJA1 IKBKB KCNIP3 MAP2K4 MAP2K7 MEX3B MYL1 NDUFS1 NEURL3 NFKB1 PROC PSEN2 QPCT RAF1 RBX1 RIPK1 RIPK2 RLIM RNF8 SKP1 SKP2 SMAD3 SPATS1 TNFRSF10B TRAF1 TRAF2 TRIM31 USP8	10 interacting genes: ATP13A2 CFLAR CPEB1 LINC00839 NUDT3 RAP1GAP SMAD4 SNUPN UBE2D3 USP7
Entrez ID		8837	84206
HPRD ID		04671	15256
Ensembl ID		ENSG00000003402	ENSG00000183496
Uniprot IDs		A0A024R3Y4 A0A336TY74 B4E361 E9PAP3 O15519 Q59F61	Q6ZN04
PDB IDs		2N5R 3H11 3H13 6M6O 7DEE 7LXC 8YBX 8YD7 8YD8 8YM4 8YM5 8YM6 8YNI 8YNK 8YNL 8YNM 8YNN
Enriched GO Terms of Interacting Partners?		Apoptotic Process Cell Death Programmed Cell Death Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Extrinsic Apoptotic Signaling Pathway MAPK Cascade Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Cell Surface Receptor Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway Signal Transduction Protein Metabolic Process JNK Cascade Cysteine-type Endopeptidase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Signaling Ubiquitin Protein Ligase Binding Ripoptosome Intracellular Signaling Cassette Positive Regulation Of Neuron Apoptotic Process Proteolysis Death-inducing Signaling Complex Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Execution Phase Of Apoptosis Response To Stress Cytosol Protein Modification Process Post-translational Protein Modification Response To External Biotic Stimulus Cellular Response To Mechanical Stimulus Cellular Response To Staurosporine Death Effector Domain Binding Protein Polyubiquitination Cysteine-type Peptidase Activity Regulation Of Signal Transduction Death Receptor Binding T Cell Activation Regulation Of Intracellular Signal Transduction Protein Maturation Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Regulation Of Cytokine Production	Regulation Of Extracellular Matrix Organization Positive Regulation Of Extracellular Matrix Organization Response To Growth Factor Intracellular Iron Ion Homeostasis Response To Decreased Oxygen Levels Cellular Response To Growth Factor Stimulus Negative Regulation Of Cardiac Myofibril Assembly Regulation Of Cardiac Muscle Cell Apoptotic Process Response To Hypoxia Negative Regulation Of Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Negative Regulation Of Thyroid Gland Epithelial Cell Proliferation Negative Regulation Of Microvillus Assembly Cysteine-type Endopeptidase Activity Inositol Diphosphate Tetrakisphosphate Diphosphatase Activity Inositol Diphosphate Pentakisphosphate Diphosphatase Activity Manganese Ion Binding Diphosphoinositol Polyphosphate Catabolic Process Spermine Transmembrane Transport ABC-type Polyamine Transporter Activity Response To Oxygen Levels Gonad Morphogenesis Regulation Of Protein Catabolic Process Nephrogenic Mesenchyme Morphogenesis Negative Regulation Of Catabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Glial Cell Derived Neurotrophic Factor Cellular Response To Stress Skeletal Myofibril Assembly SnRNA Import Into Nucleus 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] Diphosphatase Activity Inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase Activity Inositol Phosphate Catabolic Process Inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate Diphosphatase Activity Polyamine Transmembrane Transporter Activity Extracellular Exosome Biogenesis Activin Responsive Factor Complex Left Ventricular Cardiac Muscle Tissue Morphogenesis Metanephric Mesenchyme Morphogenesis Autophagosome Organization Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Myoblast Fusion Cellular Response To Insulin Stimulus Diphosphoinositol Polyphosphate Metabolic Process Bis(5'-adenosyl)-hexaphosphatase Activity Diadenosine Hexaphosphate Catabolic Process Diadenosine Pentaphosphate Catabolic Process Adenosine 5'-(hexahydrogen Pentaphosphate) Catabolic Process
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