FGF13

Description		fibroblast growth factor 13
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Microtubule Plasma Membrane Intercalated Disc Membrane Lateral Plasma Membrane Filopodium Axon Dendrite Growth Cone Sarcolemma Cell Projection Neuron Projection
	Molecular Function	Protein Binding Microtubule Binding Growth Factor Activity Sodium Channel Regulator Activity Transmembrane Transporter Binding Beta-tubulin Binding
	Biological Process	MAPK Cascade Neuron Migration Sodium Ion Transport Negative Regulation Of Microtubule Depolymerization Signal Transduction Cell-cell Signaling Nervous System Development Learning Or Memory Learning Memory Hippocampus Development Cerebral Cortex Cell Migration Neurogenesis Establishment Of Neuroblast Polarity Microtubule Polymerization Negative Regulation Of Collateral Sprouting Branching Morphogenesis Of A Nerve Protein Localization To Plasma Membrane Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Inhibitory Synapse Assembly Positive Regulation Of Voltage-gated Sodium Channel Activity
Pathways		Phase 0 - rapid depolarisation
Drugs
Diseases
GWAS		Breast cancer in BRCA2 mutation carriers ( 23544012) Response to taxane treatment (paclitaxel) ( 23006423)
Novel Interacting Genes		10 novel interacting genes: APP ARHGAP5 CFLAR FBXO7 MAPK8IP2 PLEKHF2 PRNP PSEN1 SCN8A VMP1
Interacting Genes		10 interacting genes: APP ARHGAP5 CFLAR FBXO7 MAPK8IP2 PLEKHF2 PRNP PSEN1 SCN8A VMP1
Entrez ID		2258
HPRD ID		02090
Ensembl ID		ENSG00000129682
Uniprot IDs		A8K1P5 Q92913
PDB IDs		3HBW 4DCK 4JPZ
Enriched GO Terms of Interacting Partners?		Neuron Projection Maintenance Regulation Of Neuron Apoptotic Process Neuron Projection Organization Regulation Of Apoptotic Signaling Pathway Astrocyte Activation Involved In Immune Response Positive Regulation Of Amyloid Fibril Formation Cellular Response To Amyloid-beta Growth Factor Receptor Binding Response To Amyloid-beta Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Regulation Of Biological Quality Learning Or Memory Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Negative Regulation Of Long-term Synaptic Potentiation Cognition Regulation Of Dendritic Spine Maintenance Intracellular Copper Ion Homeostasis Regulation Of Amyloid Fibril Formation Regulation Of Membrane Potential Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Mating Behavior Regulation Of Postsynapse Organization Astrocyte Activation Memory Regulation Of Programmed Cell Death Endoplasmic Reticulum Positive Regulation Of Glycolytic Process Negative Regulation Of Cell Communication Copper Ion Homeostasis Cellular Response To Copper Ion Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Molecular Function Activator Activity Modulation Of Chemical Synaptic Transmission Reproductive Behavior Positive Regulation Of Apoptotic Process Response To Copper Ion Early Endosome Membrane Regulation Of Synaptic Plasticity Positive Regulation Of Programmed Cell Death Positive Regulation Of ATP Metabolic Process Membrane Raft Dendritic Shaft Postsynapse Regulation Of Long-term Synaptic Potentiation Regulation Of Intracellular Signal Transduction
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