CFLAR and DEDD2

Number of citations of the paper that reports this interaction (PubMedID 11965497)
0

Data Source:
HPRD (in vitro, in vivo)

		CFLAR	DEDD2
Description		CASP8 and FADD like apoptosis regulator	death effector domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Ripoptosome	Nucleus Nucleoplasm Nucleolus
	Molecular Function	Protease Binding Cysteine-type Endopeptidase Activity Death Receptor Binding Protein Binding Enzyme Activator Activity Cysteine-type Peptidase Activity Protein-containing Complex Binding	DNA Binding Protein Binding Signaling Receptor Complex Adaptor Activity
	Biological Process	Response To Hypoxia Proteolysis Apoptotic Process Skeletal Muscle Tissue Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Skeletal Muscle Atrophy Regulation Of Skeletal Muscle Satellite Cell Proliferation Skeletal Myofibril Assembly Macrophage Differentiation Cellular Response To Insulin Stimulus Response To Testosterone Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Skeletal Muscle Tissue Regeneration Positive Regulation Of Neuron Apoptotic Process Regulation Of Necroptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Hypoxia Cellular Response To Dexamethasone Stimulus Cellular Response To Nitric Oxide Positive Regulation Of Glomerular Mesangial Cell Proliferation Negative Regulation Of Myoblast Fusion Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extracellular Matrix Organization Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Hepatocyte Apoptotic Process Negative Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Hepatocyte Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	RNA Processing Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors RRNA Catabolic Process Cellular Homeostasis Apoptotic Nuclear Changes Intracellular Signal Transduction Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		TRAIL signaling
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Rheumatoid arthritis ( 24390342 30423114) Triptolide cytotoxicity ( 26121980)	Meat-related diet ( 32066663)
Interacting Genes		49 interacting genes: ATF2 BCL2L1 CAB39 CASP10 CASP2 CASP3 CASP6 CASP7 CASP8 CD28 CRYGA CUL1 DAXX DEDD DEDD2 ECE1 EEF1B2 FADD FGF13 FZD5 GAPDHS GJA1 IKBKB KCNIP3 MAP2K4 MAP2K7 MEX3B MYL1 NDUFS1 NEURL3 NFKB1 PROC PSEN2 QPCT RAF1 RBX1 RIPK1 RIPK2 RLIM RNF8 SKP1 SKP2 SMAD3 SPATS1 TNFRSF10B TRAF1 TRAF2 TRIM31 USP8	12 interacting genes: ATG16L1 CASP10 CASP8 CDCA7L CDK6 CFLAR DEDD GTF3C3 HNRNPAB NR2E3 RBFOX2 RHOXF2
Entrez ID		8837	162989
HPRD ID		04671	10868
Ensembl ID		ENSG00000003402	ENSG00000160570
Uniprot IDs		A0A024R3Y4 A0A336TY74 B4E361 E9PAP3 O15519 Q59F61	Q8WXF8
PDB IDs		2N5R 3H11 3H13 6M6O 7DEE 7LXC 8YBX 8YD7 8YD8 8YM4 8YM5 8YM6 8YNI 8YNK 8YNL 8YNM 8YNN
Enriched GO Terms of Interacting Partners?		Apoptotic Process Cell Death Programmed Cell Death Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Extrinsic Apoptotic Signaling Pathway MAPK Cascade Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Cell Surface Receptor Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway Signal Transduction Protein Metabolic Process JNK Cascade Cysteine-type Endopeptidase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Signaling Ubiquitin Protein Ligase Binding Ripoptosome Intracellular Signaling Cassette Positive Regulation Of Neuron Apoptotic Process Proteolysis Death-inducing Signaling Complex Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Execution Phase Of Apoptosis Response To Stress Cytosol Protein Modification Process Post-translational Protein Modification Response To External Biotic Stimulus Cellular Response To Mechanical Stimulus Cellular Response To Staurosporine Death Effector Domain Binding Protein Polyubiquitination Cysteine-type Peptidase Activity Regulation Of Signal Transduction Death Receptor Binding T Cell Activation Regulation Of Intracellular Signal Transduction Protein Maturation Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Regulation Of Cytokine Production	Ripoptosome CD95 Death-inducing Signaling Complex Death Effector Domain Binding Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Death-inducing Signaling Complex Cysteine-type Endopeptidase Activity Positive Regulation Of Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway Death Receptor Binding Positive Regulation Of Execution Phase Of Apoptosis Cysteine-type Peptidase Activity Execution Phase Of Apoptosis Regulation Of Necroptotic Process Regulation Of Programmed Necrotic Cell Death Macrophage Differentiation Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Neuron Apoptotic Process Cyclin D2-CDK6 Complex Vacuole-isolation Membrane Contact Site Regulation Of Metabolic Process Positive Regulation Of Gene Expression Mononuclear Cell Differentiation Apoptotic Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Skeletal Myofibril Assembly Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway C-terminal Protein Lipidation Developmental Process Protein-containing Complex Binding Negative Regulation Of RNA Metabolic Process Leukocyte Differentiation Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Autophagosome Assembly Negative Regulation Of Myoblast Fusion Negative Stranded Viral RNA Replication Autophagosome Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nuclear Receptor-mediated Signaling Pathway Apoptotic Process Response To Estradiol Negative Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Editing Complex Negative Regulation Of Syncytium Formation By Plasma Membrane Fusion Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Negative Regulation Of Dendrite Extension
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