FGF13 and ARHGAP5

Number of citations of the paper that reports this interaction (PubMedID 33064958)
48

Data Source:
BioGRID (two hybrid)

		FGF13	ARHGAP5
Description		fibroblast growth factor 13	Rho GTPase activating protein 5
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Microtubule Plasma Membrane Intercalated Disc Membrane Lateral Plasma Membrane Filopodium Axon Dendrite Growth Cone Sarcolemma Cell Projection Neuron Projection	Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Binding Microtubule Binding Growth Factor Activity Sodium Channel Regulator Activity Transmembrane Transporter Binding Beta-tubulin Binding	GTPase Activity GTPase Activator Activity Protein Binding SH2 Domain Binding
	Biological Process	MAPK Cascade Neuron Migration Sodium Ion Transport Negative Regulation Of Microtubule Depolymerization Signal Transduction Cell-cell Signaling Nervous System Development Learning Or Memory Learning Memory Hippocampus Development Cerebral Cortex Cell Migration Neurogenesis Establishment Of Neuroblast Polarity Microtubule Polymerization Negative Regulation Of Collateral Sprouting Branching Morphogenesis Of A Nerve Protein Localization To Plasma Membrane Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Inhibitory Synapse Assembly Positive Regulation Of Voltage-gated Sodium Channel Activity	Positive Regulation Of Mesenchymal Cell Proliferation Cell Adhesion Signal Transduction Rho Protein Signal Transduction Regulation Of Cell Size Epithelial Cell Migration Positive Regulation Of Epithelial Cell Migration Cell Migration Mammary Gland Development Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Phase 0 - rapid depolarisation	RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle
Drugs
Diseases
GWAS		Breast cancer in BRCA2 mutation carriers ( 23544012) Response to taxane treatment (paclitaxel) ( 23006423)	Asthma ( 29273806)
Interacting Genes		10 interacting genes: APP ARHGAP5 CFLAR FBXO7 MAPK8IP2 PLEKHF2 PRNP PSEN1 SCN8A VMP1	13 interacting genes: ADRB2 CSDE1 FGF13 HSPA13 ITGA5 ITGB1 PTK2B PTPN18 RASA1 RHOA RND3 SMURF2 SUZ12
Entrez ID		2258	394
HPRD ID		02090	04060
Ensembl ID		ENSG00000129682	ENSG00000100852
Uniprot IDs		A8K1P5 Q92913	Q13017
PDB IDs		3HBW 4DCK 4JPZ	2EE4 2EE5 5U4V
Enriched GO Terms of Interacting Partners?		Neuron Projection Maintenance Regulation Of Neuron Apoptotic Process Neuron Projection Organization Regulation Of Apoptotic Signaling Pathway Astrocyte Activation Involved In Immune Response Positive Regulation Of Amyloid Fibril Formation Cellular Response To Amyloid-beta Growth Factor Receptor Binding Response To Amyloid-beta Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Regulation Of Biological Quality Learning Or Memory Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Negative Regulation Of Long-term Synaptic Potentiation Cognition Regulation Of Dendritic Spine Maintenance Intracellular Copper Ion Homeostasis Regulation Of Amyloid Fibril Formation Regulation Of Membrane Potential Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Mating Behavior Regulation Of Postsynapse Organization Astrocyte Activation Memory Regulation Of Programmed Cell Death Endoplasmic Reticulum Positive Regulation Of Glycolytic Process Negative Regulation Of Cell Communication Copper Ion Homeostasis Cellular Response To Copper Ion Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Molecular Function Activator Activity Modulation Of Chemical Synaptic Transmission Reproductive Behavior Positive Regulation Of Apoptotic Process Response To Copper Ion Early Endosome Membrane Regulation Of Synaptic Plasticity Positive Regulation Of Programmed Cell Death Positive Regulation Of ATP Metabolic Process Membrane Raft Dendritic Shaft Postsynapse Regulation Of Long-term Synaptic Potentiation Regulation Of Intracellular Signal Transduction	Integrin Alpha5-beta1 Complex Wound Healing, Spreading Of Cells Regulation Of Developmental Process Focal Adhesion Cell-cell Adhesion Mediated By Integrin Anatomical Structure Formation Involved In Morphogenesis Plasma Membrane Regulation Of Cell-substrate Adhesion CD40 Signaling Pathway Regulation Of Cytoskeleton Organization Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Ruffle Membrane Integrin-mediated Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Wound Healing, Spreading Of Epidermal Cells Cell-matrix Adhesion Angiogenesis Ruffle Cell Differentiation Negative Regulation Of Anoikis Regulation Of Actin Cytoskeleton Organization Regulation Of Cell-matrix Adhesion Signal Transduction Regulation Of Organelle Organization Contractile Actin Filament Bundle Assembly Stress Fiber Assembly Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Bone Resorption Blood Vessel Diameter Maintenance Regulation Of Tube Size Cell-substrate Adhesion Regulation Of Supramolecular Fiber Organization Neuron Migration Regulation Of Actin Filament-based Process Regulation Of Anoikis Integrin Complex Cell Adhesion Mediated By Integrin LncRNA Binding Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Developmental Process Cerebral Cortex Cell Migration Response To Muscle Activity Positive Regulation Of Excitatory Postsynaptic Potential Cell Surface Receptor Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Apoptotic Process Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Angiogenesis
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