DVL2 and THAP1

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DVL2	THAP1
Description		dishevelled segment polarity protein 2	THAP domain containing 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Aggresome Lateral Plasma Membrane Nuclear Body Clathrin-coated Vesicle Cytoplasmic Vesicle Apical Part Of Cell Clathrin-coated Endocytic Vesicle	Chromatin Fibrillar Center Nucleus Nucleoplasm PML Body
	Molecular Function	Frizzled Binding Protein Binding Protein Kinase Binding Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Small GTPase Binding Identical Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Neural Tube Closure Heart Looping Heart Morphogenesis Outflow Tract Morphogenesis Regulation Of DNA-templated Transcription Segment Specification Heart Development Intracellular Protein Localization Wnt Signaling Pathway Convergent Extension Involved In Neural Plate Elongation Regulation Of Actin Cytoskeleton Organization Segmentation Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Convergent Extension Involved In Organogenesis Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Cochlea Morphogenesis Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Signal Transduction By P53 Class Mediator	Negative Regulation Of Transcription By RNA Polymerase II Endothelial Cell Proliferation DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Cell Cycle
Pathways		TCF dependent signaling in response to WNT WNT mediated activation of DVL Signaling by Hippo PCP/CE pathway PCP/CE pathway Asymmetric localization of PCP proteins Degradation of DVL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane WNT5A-dependent internalization of FZD4 Negative regulation of TCF-dependent signaling by DVL-interacting proteins RHO GTPases Activate Formins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping
Drugs
Diseases			Primary torsion dystonia (PTD)
GWAS		Metabolite levels ( 31628463)	Pelvic organ prolapse (moderate/severe) ( 26545240)
Interacting Genes		106 interacting genes: ABL1 AKAP9 AP1M1 AP2M1 AQP9 ARHGEF39 ARR3 ARRB1 ARRB2 ATN1 AXIN1 BAG3 BAHD1 BCL6 BEND7 BYSL CARD9 CCDC33 CPSF7 CSNK1E CTBP2 CUL1 DAAM1 DCUN1D1 DDI1 DPPA2 DYNLT1 EIF1B ELOA2 ENKD1 FAM161A FAM90A1 FZD4 GABARAP GABARAPL1 GMCL2 GOLGA2 GRAP2 GRB2 HIP1 IHO1 LMO3 LRRK2 MAGOHB MAP1LC3A MCRS1 NOL12 NUP62CL NUP88 OTULIN PARD6A PCBD1 PLA2G12A POLI PPM1A PPP1R16B PRKAA1 PRKCA PRKCB PRKCG PRPF3 PRPF31 PSMF1 RAC1 RAP1B RBFOX1 RBPMS RHOA RHOXF2 RNF185 RNPS1 RUNX2 RUSC1 SCNM1 SMURF1 SNF8 SNIP1 SORBS3 SSX2IP TAB1 TDP2 THAP1 TIFA TLE5 TP53 TPM3 TRAF2 U2AF2 UBAC1 UIMC1 USP5 USP9X VANGL1 VHL WAS WT1 WWP2 YES1 ZBTB48 ZBTB8A ZGPAT ZNF165 ZNF250 ZNF263 ZNF410 ZNF581	114 interacting genes: ABCF3 ACOT7 AEBP2 AKAP17A AKAP9 AP2B1 APP ARL6IP4 BAG5 BEND7 BMS1P1 BYSL C1orf216 C1orf35 CDC37 CDKN2D CHD2 CHLSN CSNK2A1 DCAF8 DRC4 DVL2 FAM124A FAM133A FAM9A FGF10 FGF11 FGF12 FXR2 GOLGA7 GPATCH2L HNRNPLL HTATSF1 HYPK INO80B ITGA5 KANK2 KLF12 KRTAP10-7 L3MBTL2 LASP1 LMNB2 LMO3 LNX1 METTL13 MFAP1 MIS18A MORF4L1 MORF4L2 MRPL11 MRPL53 NDUFAB1 NKAP NKAPD1 NTAQ1 NUP62 PAWR PDIA6 PFKFB3 PHF1 PHF19 PID1 PNKP POLR2L POLR2M POMK POU6F2 PPIG PRKAA1 PRR20A PRR20B PRR20C PRR20D PRR20E QKI RAD54L2 RALY RALYL RBM10 RBM39 RIPPLY1 RNF170 RNF4 RP9P RPL22 RPS25 SAP30BP SERF2 SLU7 SPANXN2 SPMIP2 SREK1IP1 STRBP TCEA2 TCEANC TPM3 TPT1P8 TRAF5 TRIM26 TRIP10 TTLL10 TXN2 U2AF2 UBE2I VCX2 WT1 YES1 ZBTB48 ZCCHC10 ZGPAT ZMAT4 ZNF385C ZNF408 ZNF526
Entrez ID		1856	55145
HPRD ID		03690	15496
Ensembl ID		ENSG00000004975	ENSG00000131931
Uniprot IDs		O14641	Q9NVV9
PDB IDs		2REY 3CBX 3CBY 3CBZ 3CC0 4WIP 5LNP 5SUY 5SUZ 6IW3 6JCK 8WM9 8WMA 8WWR 8YR7	2JTG 2KO0 2L1G
Enriched GO Terms of Interacting Partners?		Protein Binding Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Non-canonical Wnt Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Wnt Signaling Pathway Regulation Of Signal Transduction Intracellular Signaling Cassette Negative Regulation Of Macromolecule Metabolic Process Regulation Of Intracellular Signal Transduction Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Cytosol Protein Modification By Small Protein Conjugation Protein Ubiquitination Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Protein Modification Process Nucleoplasm Cytoplasm Regulation Of Signaling Regulation Of Cell Communication Regulation Of Protein Ubiquitination Negative Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process Protein Modification Process Cellular Component Assembly Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Enzyme Binding Cytoskeleton Regulation Of Transcription By RNA Polymerase II Intracellular Signal Transduction Macromolecule Metabolic Process Positive Regulation Of Signal Transduction Regulation Of MAPK Cascade Negative Regulation Of RNA Metabolic Process Post-translational Protein Modification Autophagy	Nucleus RNA Splicing Nucleic Acid Binding RNA Binding Protein Binding MRNA Processing Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process PTB Domain Binding ESC/E(Z) Complex Regulation Of Nucleobase-containing Compound Metabolic Process RNA Processing MRNA Metabolic Process Positive Regulation Of Fat Cell Proliferation
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