THAP1 and ARL6IP4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		THAP1	ARL6IP4
Description		THAP domain containing 1	ARF like GTPase 6 interacting protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleus Nucleoplasm PML Body	Nucleus Nucleolus Nuclear Speck
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding	RNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Endothelial Cell Proliferation DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Cell Cycle	MRNA Processing RNA Splicing
Pathways
Drugs
Diseases		Primary torsion dystonia (PTD)
GWAS		Pelvic organ prolapse (moderate/severe) ( 26545240)	Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Schizophrenia ( 23974872 25056061 29483656) Tourette syndrome ( 30818990)
Interacting Genes		114 interacting genes: ABCF3 ACOT7 AEBP2 AKAP17A AKAP9 AP2B1 APP ARL6IP4 BAG5 BEND7 BMS1P1 BYSL C1orf216 C1orf35 CDC37 CDKN2D CHD2 CHLSN CSNK2A1 DCAF8 DRC4 DVL2 FAM124A FAM133A FAM9A FGF10 FGF11 FGF12 FXR2 GOLGA7 GPATCH2L HNRNPLL HTATSF1 HYPK INO80B ITGA5 KANK2 KLF12 KRTAP10-7 L3MBTL2 LASP1 LMNB2 LMO3 LNX1 METTL13 MFAP1 MIS18A MORF4L1 MORF4L2 MRPL11 MRPL53 NDUFAB1 NKAP NKAPD1 NTAQ1 NUP62 PAWR PDIA6 PFKFB3 PHF1 PHF19 PID1 PNKP POLR2L POLR2M POMK POU6F2 PPIG PRKAA1 PRR20A PRR20B PRR20C PRR20D PRR20E QKI RAD54L2 RALY RALYL RBM10 RBM39 RIPPLY1 RNF170 RNF4 RP9P RPL22 RPS25 SAP30BP SERF2 SLU7 SPANXN2 SPMIP2 SREK1IP1 STRBP TCEA2 TCEANC TPM3 TPT1P8 TRAF5 TRIM26 TRIP10 TTLL10 TXN2 U2AF2 UBE2I VCX2 WT1 YES1 ZBTB48 ZCCHC10 ZGPAT ZMAT4 ZNF385C ZNF408 ZNF526	22 interacting genes: AP1M1 ARL6 C1orf35 CEBPA CSNK2A1 ETS1 FOS IKBKG KRCC1 NKAPD1 NKAPL RBM39 RNF41 SBNO1 SREK1 SRPK2 SRRM4 SRSF11 THAP1 TRIM55 TRIM63 WEE2-AS1
Entrez ID		55145	51329
HPRD ID		15496	09640
Ensembl ID		ENSG00000131931	ENSG00000182196
Uniprot IDs		Q9NVV9	A0A0C4DG62 A0A0C4DH18 A0A8C8KBE9 F8WCT1 F8WEP2 Q66PJ3
PDB IDs		2JTG 2KO0 2L1G
Enriched GO Terms of Interacting Partners?		Nucleus RNA Splicing Nucleic Acid Binding RNA Binding Protein Binding MRNA Processing Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process PTB Domain Binding ESC/E(Z) Complex Regulation Of Nucleobase-containing Compound Metabolic Process RNA Processing MRNA Metabolic Process Positive Regulation Of Fat Cell Proliferation	RNA Metabolic Process Identical Protein Binding Nucleic Acid Metabolic Process MRNA Metabolic Process RNA Splicing MRNA Processing Nuclear Body Organization Regulation Of MRNA Splicing, Via Spliceosome
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