THAP1 and PFKFB3

		THAP1	PFKFB3
Description		THAP domain containing 1	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Image
GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleus Nucleoplasm PML Body	Nucleoplasm Cytosol 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding	Nucleotide Binding Catalytic Activity 6-phosphofructo-2-kinase Activity Fructose-2,6-bisphosphate 2-phosphatase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Hydrolase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Endothelial Cell Proliferation DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Cell Cycle	Fructose Metabolic Process Fructose 2,6-bisphosphate Metabolic Process Gluconeogenesis Glycolytic Process Apoptotic Process Glial Cell Differentiation Carbohydrate Phosphorylation Motor Behavior
Pathways			Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
Drugs
Diseases		Primary torsion dystonia (PTD)
GWAS		Pelvic organ prolapse (moderate/severe) ( 26545240)	Alopecia areata ( 25608926) Asthma ( 31619474 31959851) Asthma (childhood onset) ( 31036433) Celiac disease ( 22057235 24999842) Crohn's disease ( 28067908) Latent autoimmune diabetes ( 30254083) Metabolite levels ( 23823483) Obesity (extreme) ( 31888951) Plasma anti-thyroid peroxidase levels ( 29678681) Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) ( 25117820) Selective IgA deficiency ( 27723758) Western dietary pattern ( 28644415)
Interacting Genes		114 interacting genes: ABCF3 ACOT7 AEBP2 AKAP17A AKAP9 AP2B1 APP ARL6IP4 BAG5 BEND7 BMS1P1 BYSL C1orf216 C1orf35 CDC37 CDKN2D CHD2 CHLSN CSNK2A1 DCAF8 DRC4 DVL2 FAM124A FAM133A FAM9A FGF10 FGF11 FGF12 FXR2 GOLGA7 GPATCH2L HNRNPLL HTATSF1 HYPK INO80B ITGA5 KANK2 KLF12 KRTAP10-7 L3MBTL2 LASP1 LMNB2 LMO3 LNX1 METTL13 MFAP1 MIS18A MORF4L1 MORF4L2 MRPL11 MRPL53 NDUFAB1 NKAP NKAPD1 NTAQ1 NUP62 PAWR PDIA6 PFKFB3 PHF1 PHF19 PID1 PNKP POLR2L POLR2M POMK POU6F2 PPIG PRKAA1 PRR20A PRR20B PRR20C PRR20D PRR20E QKI RAD54L2 RALY RALYL RBM10 RBM39 RIPPLY1 RNF170 RNF4 RP9P RPL22 RPS25 SAP30BP SERF2 SLU7 SPANXN2 SPMIP2 SREK1IP1 STRBP TCEA2 TCEANC TPM3 TPT1P8 TRAF5 TRIM26 TRIP10 TTLL10 TXN2 U2AF2 UBE2I VCX2 WT1 YES1 ZBTB48 ZCCHC10 ZGPAT ZMAT4 ZNF385C ZNF408 ZNF526	6 interacting genes: CTNNB1 GATA3 GCK OTUD4 PFKFB1 THAP1
Entrez ID		55145	5209
HPRD ID		15496	05612
Ensembl ID		ENSG00000131931	ENSG00000170525
Uniprot IDs		Q9NVV9	A0A1W2PR17 B7Z8A0 Q16875
PDB IDs		2JTG 2KO0 2L1G	2AXN 2DWO 2DWP 2I1V 3QPU 3QPV 3QPW 4D4J 4D4K 4D4L 4D4M 4MA4 5AJV 5AJW 5AJX 5AJY 5AJZ 5AK0 6ETJ 6HVH 6HVI 6HVJ 6IBX 6IBY 6IBZ 6IC0
Enriched GO Terms of Interacting Partners?		Nucleus RNA Splicing Nucleic Acid Binding RNA Binding Protein Binding MRNA Processing Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process PTB Domain Binding ESC/E(Z) Complex Regulation Of Nucleobase-containing Compound Metabolic Process RNA Processing MRNA Metabolic Process Positive Regulation Of Fat Cell Proliferation	Nephron Tubule Formation Histone Methyltransferase Binding Nucleobase-containing Compound Metabolic Process Regulation Of Nephron Tubule Epithelial Cell Differentiation Mesenchymal To Epithelial Transition Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Carbohydrate Phosphorylation Embryonic Epithelial Tube Formation Epithelial Tube Formation Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Morphogenesis Of An Epithelium Thymus Development Cell Fate Determination T Cell Differentiation In Thymus ADP Catabolic Process ADP Metabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Nucleoside Diphosphate Catabolic Process Regulation Of Glycolytic Process Glycolytic Process Ribonucleoside Diphosphate Catabolic Process DNA-templated Transcription Regulation Of Animal Organ Morphogenesis Glial Cell Fate Determination Regulation Of Morphogenesis Of An Epithelium Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Regulation Of Cellular Response To X-ray Negative Regulation Of Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation Type IV Hypersensitivity Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation Negative Regulation Of Cell Proliferation Involved In Mesonephros Development Pyruvate Metabolic Process Purine Ribonucleotide Catabolic Process Regulation Of Carbohydrate Catabolic Process Regulation Of ATP Metabolic Process Ribonucleoside Diphosphate Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Nucleoside Diphosphate Metabolic Process Purine Nucleotide Catabolic Process Mesenchymal Stem Cell Differentiation Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Beta-catenin-ICAT Complex Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Canonical Wnt Signaling Pathway Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Epithelial Tube Morphogenesis
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?