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DVL2 and RUSC1
Number of citations of the paper that reports this interaction (PubMedID
21516116
)
20
Data Source:
BioGRID
(two hybrid)
DVL2
RUSC1
Description
dishevelled segment polarity protein 2
RUN and SH3 domain containing 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Aggresome
Lateral Plasma Membrane
Nuclear Body
Clathrin-coated Vesicle
Cytoplasmic Vesicle
Apical Part Of Cell
Clathrin-coated Endocytic Vesicle
Nucleus
Cytoplasm
Endosome
Early Endosome
Golgi Apparatus
Cytosol
Cytoskeleton
Microtubule
Postsynaptic Density
Microtubule Cytoskeleton
Cytoplasmic Vesicle
Synapse
Molecular Function
Frizzled Binding
Protein Binding
Protein Kinase Binding
Protein Domain Specific Binding
Protein-macromolecule Adaptor Activity
Small GTPase Binding
Identical Protein Binding
Actin Binding
Protein Binding
Biological Process
Neural Tube Closure
Heart Looping
Heart Morphogenesis
Outflow Tract Morphogenesis
Regulation Of DNA-templated Transcription
Segment Specification
Heart Development
Intracellular Protein Localization
Wnt Signaling Pathway
Convergent Extension Involved In Neural Plate Elongation
Regulation Of Actin Cytoskeleton Organization
Segmentation
Intracellular Signal Transduction
Non-canonical Wnt Signaling Pathway
Regulation Of Cell Population Proliferation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of JNK Cascade
Convergent Extension Involved In Organogenesis
Canonical Wnt Signaling Pathway
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Cochlea Morphogenesis
Positive Regulation Of Neuron Projection Arborization
Positive Regulation Of Signal Transduction By P53 Class Mediator
Protein Polyubiquitination
Pathways
TCF dependent signaling in response to WNT
WNT mediated activation of DVL
Signaling by Hippo
PCP/CE pathway
PCP/CE pathway
Asymmetric localization of PCP proteins
Degradation of DVL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
WNT5A-dependent internalization of FZD4
Negative regulation of TCF-dependent signaling by DVL-interacting proteins
RHO GTPases Activate Formins
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
WNT5:FZD7-mediated leishmania damping
WNT5:FZD7-mediated leishmania damping
Drugs
Diseases
GWAS
Metabolite levels (
31628463
)
Body fat distribution (leg fat ratio) (
30664634
)
Body fat distribution (trunk fat ratio) (
30664634
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (min-P) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (min-P) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Interacting Genes
106 interacting genes:
ABL1
AKAP9
AP1M1
AP2M1
AQP9
ARHGEF39
ARR3
ARRB1
ARRB2
ATN1
AXIN1
BAG3
BAHD1
BCL6
BEND7
BYSL
CARD9
CCDC33
CPSF7
CSNK1E
CTBP2
CUL1
DAAM1
DCUN1D1
DDI1
DPPA2
DYNLT1
EIF1B
ELOA2
ENKD1
FAM161A
FAM90A1
FZD4
GABARAP
GABARAPL1
GMCL2
GOLGA2
GRAP2
GRB2
HIP1
IHO1
LMO3
LRRK2
MAGOHB
MAP1LC3A
MCRS1
NOL12
NUP62CL
NUP88
OTULIN
PARD6A
PCBD1
PLA2G12A
POLI
PPM1A
PPP1R16B
PRKAA1
PRKCA
PRKCB
PRKCG
PRPF3
PRPF31
PSMF1
RAC1
RAP1B
RBFOX1
RBPMS
RHOA
RHOXF2
RNF185
RNPS1
RUNX2
RUSC1
SCNM1
SMURF1
SNF8
SNIP1
SORBS3
SSX2IP
TAB1
TDP2
THAP1
TIFA
TLE5
TP53
TPM3
TRAF2
U2AF2
UBAC1
UIMC1
USP5
USP9X
VANGL1
VHL
WAS
WT1
WWP2
YES1
ZBTB48
ZBTB8A
ZGPAT
ZNF165
ZNF250
ZNF263
ZNF410
ZNF581
93 interacting genes:
ABHD11
ABHD5
ABI2
AIRIM
AKAP8L
ANKS1A
APP
ATP6V0D2
BPIFA1
CCDC120
CCDC57
CCHCR1
CCNC
CDKN2B
CMTM6
CREM
CRYBA2
CTAG1A
CTAG1B
DMRT3
DOK6
DPH5
DTX2
DVL2
EXOC8
EXOSC8
FAM9B
FNDC3B
GCM2
HMG20A
HNRNPF
INSC
KCTD9
KRTAP19-1
KRTAP19-5
KRTAP6-2
KRTAP8-1
LIMS3
LIMS4
LMO2
MAGEA3
MAGEA6
MAGED1
MED25
MEIS2
MISP
MOAP1
MORN3
MYOZ3
N4BP3
NICN1
NTAQ1
NTRK1
NUDT22
OIP5
P4HA3
PFDN5
PIK3R3
PLA2G6
PM20D2
PNMA1
POLR1C
PRDM14
PRR35
RBPMS
SMARCB1
SMYD1
SOHLH1
SPAG8
STUB1
SUOX
TBC1D25
TCHP
TEKT4
TENT5B
TLE5
TRAPPC6A
TRIM55
TRIM63
TRIM73
TSSK3
TTC19
TTC7B
UFSP1
VGLL3
WWOX
WWP2
ZIC1
ZMYND12
ZNF34
ZNF620
ZNF765
ZNF77
Entrez ID
1856
23623
HPRD ID
03690
10206
Ensembl ID
ENSG00000004975
ENSG00000160753
Uniprot IDs
O14641
A0A8Q3SIT1
B4DQB8
Q9BVN2
PDB IDs
2REY
3CBX
3CBY
3CBZ
3CC0
4WIP
5LNP
5SUY
5SUZ
6IW3
6JCK
8WM9
8WMA
8WWR
8YR7
4GIW
Enriched GO Terms of Interacting Partners
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Protein Binding
Regulation Of RNA Metabolic Process
Regulation Of Primary Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Nucleus
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Non-canonical Wnt Signaling Pathway
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Wnt Signaling Pathway
Regulation Of Signal Transduction
Intracellular Signaling Cassette
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Intracellular Signal Transduction
Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity
Regulation Of Protein Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Cytosol
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Protein Modification Process
Nucleoplasm
Cytoplasm
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Protein Ubiquitination
Negative Regulation Of Protein Metabolic Process
Negative Regulation Of Biosynthetic Process
Protein Modification Process
Cellular Component Assembly
Regulation Of Proteasomal Protein Catabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Enzyme Binding
Cytoskeleton
Regulation Of Transcription By RNA Polymerase II
Intracellular Signal Transduction
Macromolecule Metabolic Process
Positive Regulation Of Signal Transduction
Regulation Of MAPK Cascade
Negative Regulation Of RNA Metabolic Process
Post-translational Protein Modification
Autophagy
Protein Binding
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Tagcloud (Intersection)
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