DTYMK and CDC20

Number of citations of the paper that reports this interaction (PubMedID 16103219)
41

Data Source:
BioGRID (enzymatic study)

		DTYMK	CDC20
Description		deoxythymidylate kinase	cell division cycle 20
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol	Chromosome, Centromeric Region Kinetochore Spindle Pole Nucleoplasm Anaphase-promoting Complex Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Protein-containing Complex Mitotic Checkpoint Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Nucleoside Diphosphate Kinase Activity DTMP Kinase Activity ATP Binding Kinase Activity Transferase Activity	Protein Binding Anaphase-promoting Complex Binding Histone Deacetylase Binding Ubiquitin-protein Transferase Activator Activity Ubiquitin-like Ligase-substrate Adaptor Activity Ubiquitin Ligase Activator Activity
	Biological Process	DUDP Biosynthetic Process DTDP Biosynthetic Process DTTP Biosynthetic Process Nucleotide Biosynthetic Process Thymidine Biosynthetic Process Cellular Response To Growth Factor Stimulus	G2/M Transition Of Mitotic Cell Cycle Mitotic Sister Chromatid Cohesion Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Mitotic Cell Cycle Nervous System Development Positive Regulation Of Cell Population Proliferation Protein Ubiquitination Protein Deubiquitination Cell Differentiation Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Synaptic Plasticity Regulation Of Meiotic Nuclear Division Metaphase/anaphase Transition Of Cell Cycle Positive Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Dendrite Development Cell Division Regulation Of Meiotic Cell Cycle Positive Regulation Of Synapse Maturation Mitotic Spindle Assembly Positive Regulation Of Ubiquitin Protein Ligase Activity Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Metaphase/anaphase Transition Of Meiosis I
Pathways		Interconversion of nucleotide di- and triphosphates	Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal APC/C:Cdc20 mediated degradation of Cyclin B SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of Emi1 APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Ub-specific processing proteases Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Thymidine monophosphate 2',3'-Dideoxythymidine-5'-Monophosphate 3'-Fluoro-3'-deoxythymidine 5'-monophosphate 3'-deoxy-3'-aminothymidine monophosphate p1-(5'-adenosyl)p5-(5'-thymidyl)pentaphosphate Zidovudine monophosphate P1-(5'-Adenosyl)P5-(5'-(3'azido-3'-Deoxythymidyl))Pentaphosphate Phosphoaminophosphonic Acid-Adenylate Ester
Diseases
GWAS		Asthma ( 31959851) Diverticular disease ( 30177863) Prostate cancer ( 23535732)	Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) ( 27114598) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		5 interacting genes: CDC20 CEBPA DHFR FZR1 HSD17B7	53 interacting genes: ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC7 APP AURKA BUB1 BUB1B CCNA1 CCNA2 CDC16 CDC27 CDC6 CDK1 CDR2 CDT1 DCPS DTYMK EGLN3 FADD FBXO5 GMNN H2BC3 H3C1 HDAC1 HDAC2 HSF1 HSF2 KIF18A MAD2L1 MAD2L2 MCL1 MKI67 NEK2 OTUD7B PIM1 PTTG1 RASSF1 SIRT2 SOSTDC1 SPATC1 TBK1 TCP1 TGFBR1 TK1 TP63 TRAF1 TRIP13 UBC UBE2C UBE2S UBR5
Entrez ID		1841	991
HPRD ID		01773	04686
Ensembl ID		ENSG00000168393	ENSG00000117399
Uniprot IDs		P23919 Q53F55 Q6FGU2	Q12834
PDB IDs		1E2D 1E2E 1E2F 1E2G 1E2Q 1E98 1E99 1E9A 1E9B 1E9C 1E9D 1E9E 1E9F 1NMX 1NMY 1NMZ 1NN0 1NN1 1NN3 1NN5 2XX3	4GGA 4GGC 4GGD 4N14 5G04 5KHR 5KHU 5LCW 6F0X 6Q6G 6Q6H 9I68 9I69 9I6A
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Anaphase-promoting Complex Binding Ubiquitin-protein Transferase Activator Activity Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ubiquitin Ligase Activator Activity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Protein Catabolic Process Anaphase-promoting Complex Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Meiotic Nuclear Division Alcohol Metabolic Process Negative Regulation Of Cell Cycle Regulation Of Protein Catabolic Process Regulation Of Proteolysis Regulation Of Meiotic Cell Cycle Small Molecule Biosynthetic Process Small Molecule Metabolic Process Regulation Of Protein Metabolic Process Metaphase/anaphase Transition Of Meiosis I RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Methotrexate Positive Regulation Of Catabolic Process Ubiquitin-like Ligase-substrate Adaptor Activity Positive Regulation Of Protein Ubiquitination Cholesterol Metabolic Process Positive Regulation Of Post-translational Protein Modification Histone Deacetylase Binding Sterol Metabolic Process Regeneration Response To Vitamin B2 C/EBP Complex Dihydrofolate Reductase Activity Regulation Of Nuclear Division CHOP-C/EBP Complex Embryonic Organ Development Dihydrofolate Metabolic Process DNA Synthesis Involved In Mitotic DNA Replication Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Protein Metabolic Process Meiotic Cell Cycle Phase Transition	Cell Division Regulation Of Mitotic Cell Cycle Anaphase-promoting Complex Regulation Of Chromosome Segregation Regulation Of Sister Chromatid Segregation Regulation Of Cell Cycle Regulation Of Chromosome Organization Regulation Of Nuclear Division Anaphase-promoting Complex-dependent Catabolic Process Protein K11-linked Ubiquitination Regulation Of Mitotic Nuclear Division Regulation Of Cell Cycle Process Protein Branched Polyubiquitination Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Meiotic Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Chromosome Separation Positive Regulation Of Cell Cycle Regulation Of Organelle Organization Regulation Of Reproductive Process Nucleoplasm Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Nucleus Protein Modification Process Positive Regulation Of Cell Cycle Process Mitotic Cell Cycle Phase Transition Protein K48-linked Ubiquitination Cytosol Cell Cycle Phase Transition Spindle Negative Regulation Of Mitotic Metaphase/anaphase Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Mitotic Nuclear Division Post-translational Protein Modification Positive Regulation Of Cell Cycle Phase Transition Metaphase/anaphase Transition Of Mitotic Cell Cycle Metaphase/anaphase Transition Of Cell Cycle Negative Regulation Of Cell Cycle Mitotic Spindle Negative Regulation Of Cell Cycle Process Macromolecule Metabolic Process Regulation Of Cellular Component Organization Protein Polyubiquitination Modification-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Proteasomal Protein Catabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Phase Transition
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