CDC20 and ANAPC7

Number of citations of the paper that reports this interaction (PubMedID 10318877)
0

Data Source:
HPRD (in vitro, in vivo)

		CDC20	ANAPC7
Description		cell division cycle 20	anaphase promoting complex subunit 7
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Spindle Pole Nucleoplasm Anaphase-promoting Complex Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Protein-containing Complex Mitotic Checkpoint Complex Perinuclear Region Of Cytoplasm	Heterochromatin Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Spindle Cytosol Cytoskeleton Microtubule Cytoskeleton Intercellular Bridge Mitotic Spindle
	Molecular Function	Protein Binding Anaphase-promoting Complex Binding Histone Deacetylase Binding Ubiquitin-protein Transferase Activator Activity Ubiquitin-like Ligase-substrate Adaptor Activity Ubiquitin Ligase Activator Activity	Protein Phosphatase Binding Enzyme-substrate Adaptor Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Sister Chromatid Cohesion Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Mitotic Cell Cycle Nervous System Development Positive Regulation Of Cell Population Proliferation Protein Ubiquitination Protein Deubiquitination Cell Differentiation Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Synaptic Plasticity Regulation Of Meiotic Nuclear Division Metaphase/anaphase Transition Of Cell Cycle Positive Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Dendrite Development Cell Division Regulation Of Meiotic Cell Cycle Positive Regulation Of Synapse Maturation Mitotic Spindle Assembly Positive Regulation Of Ubiquitin Protein Ligase Activity Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Metaphase/anaphase Transition Of Meiosis I	Regulation Of Mitotic Cell Cycle Brain Development Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Branched Polyubiquitination
Pathways		Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal APC/C:Cdc20 mediated degradation of Cyclin B SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of Emi1 APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Ub-specific processing proteases Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation Antigen processing: Ubiquitination & Proteasome degradation	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) ( 27114598) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Bipolar disorder ( 31043756) QT interval ( 30679814) Schizophrenia ( 28991256) Total intracranial volume ( 31530798)
Interacting Genes		53 interacting genes: ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC7 APP AURKA BUB1 BUB1B CCNA1 CCNA2 CDC16 CDC27 CDC6 CDK1 CDR2 CDT1 DCPS DTYMK EGLN3 FADD FBXO5 GMNN H2BC3 H3C1 HDAC1 HDAC2 HSF1 HSF2 KIF18A MAD2L1 MAD2L2 MCL1 MKI67 NEK2 OTUD7B PIM1 PTTG1 RASSF1 SIRT2 SOSTDC1 SPATC1 TBK1 TCP1 TGFBR1 TK1 TP63 TRAF1 TRIP13 UBC UBE2C UBE2S UBR5	19 interacting genes: ANAPC10 ANAPC2 BUB1B CDC16 CDC20 CDC27 CDH1 CDT1 CEBPA CREBBP FBXO5 FZR1 HSPB1 OGT PTEN PTGER4 UBC UBE2S WASHC4
Entrez ID		991	51434
HPRD ID		04686	16233
Ensembl ID		ENSG00000117399	ENSG00000196510
Uniprot IDs		Q12834	Q4KMX6 Q9UJX3
PDB IDs		4GGA 4GGC 4GGD 4N14 5G04 5KHR 5KHU 5LCW 6F0X 6Q6G 6Q6H 9I68 9I69 9I6A	3FFL 4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9GAW
Enriched GO Terms of Interacting Partners?		Cell Division Regulation Of Mitotic Cell Cycle Anaphase-promoting Complex Regulation Of Chromosome Segregation Regulation Of Sister Chromatid Segregation Regulation Of Cell Cycle Regulation Of Chromosome Organization Regulation Of Nuclear Division Anaphase-promoting Complex-dependent Catabolic Process Protein K11-linked Ubiquitination Regulation Of Mitotic Nuclear Division Regulation Of Cell Cycle Process Protein Branched Polyubiquitination Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Meiotic Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Chromosome Separation Positive Regulation Of Cell Cycle Regulation Of Organelle Organization Regulation Of Reproductive Process Nucleoplasm Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Nucleus Protein Modification Process Positive Regulation Of Cell Cycle Process Mitotic Cell Cycle Phase Transition Protein K48-linked Ubiquitination Cytosol Cell Cycle Phase Transition Spindle Negative Regulation Of Mitotic Metaphase/anaphase Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Mitotic Nuclear Division Post-translational Protein Modification Positive Regulation Of Cell Cycle Phase Transition Metaphase/anaphase Transition Of Mitotic Cell Cycle Metaphase/anaphase Transition Of Cell Cycle Negative Regulation Of Cell Cycle Mitotic Spindle Negative Regulation Of Cell Cycle Process Macromolecule Metabolic Process Regulation Of Cellular Component Organization Protein Polyubiquitination Modification-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Proteasomal Protein Catabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Phase Transition	Anaphase-promoting Complex Anaphase-promoting Complex-dependent Catabolic Process Anaphase-promoting Complex Binding Regulation Of Meiotic Cell Cycle Protein K11-linked Ubiquitination Cell Division Metaphase/anaphase Transition Of Cell Cycle Regulation Of Reproductive Process Regulation Of Mitotic Cell Cycle Regulation Of Sister Chromatid Segregation Regulation Of Cell Cycle Protein Branched Polyubiquitination Post-translational Protein Modification Regulation Of Chromosome Segregation Protein Ubiquitination Protein Modification Process Regulation Of Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Cell Cycle Process Metaphase/anaphase Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Modification-dependent Protein Catabolic Process Negative Regulation Of Cell Cycle Phase Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Spindle Regulation Of Chromosome Organization Ubiquitin Ligase Activator Activity Regulation Of Cell Cycle Phase Transition Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Cell Cycle Process Nucleoplasm Regulation Of Nuclear Division Protein Polyubiquitination Proteasomal Protein Catabolic Process Mitotic Cell Cycle Phase Transition Intracellular Signal Transduction Regulation Of Mitotic Sister Chromatid Separation Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Chromosome Separation Ubiquitin-dependent Protein Catabolic Process Regulation Of Cellular Component Organization Proteolysis Regulation Of Organelle Organization Regulation Of Protein Ubiquitination Negative Regulation Of Cellular Senescence
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