CDC20 and HSF1

Number of citations of the paper that reports this interaction (PubMedID 18059335)
0

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)

		CDC20	HSF1
Description		cell division cycle 20	heat shock transcription factor 1
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Spindle Pole Nucleoplasm Anaphase-promoting Complex Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Protein-containing Complex Mitotic Checkpoint Complex Perinuclear Region Of Cytoplasm	Chromosome, Centromeric Region Kinetochore Chromatin Euchromatin Heterochromatin Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytosol Cytoskeleton PML Body Protein-containing Complex Pronucleus Perinuclear Region Of Cytoplasm Nuclear Stress Granule Mitotic Spindle Pole Protein Folding Chaperone Complex Ribonucleoprotein Complex
	Molecular Function	Protein Binding Anaphase-promoting Complex Binding Histone Deacetylase Binding Ubiquitin-protein Transferase Activator Activity Ubiquitin-like Ligase-substrate Adaptor Activity Ubiquitin Ligase Activator Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding Heat Shock Protein Binding Chromatin DNA Binding Identical Protein Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Hsp90 Protein Binding Translation Elongation Factor Binding STAT Family Protein Binding Sequence-specific Single Stranded DNA Binding General Transcription Initiation Factor Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Sister Chromatid Cohesion Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Mitotic Cell Cycle Nervous System Development Positive Regulation Of Cell Population Proliferation Protein Ubiquitination Protein Deubiquitination Cell Differentiation Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Synaptic Plasticity Regulation Of Meiotic Nuclear Division Metaphase/anaphase Transition Of Cell Cycle Positive Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Dendrite Development Cell Division Regulation Of Meiotic Cell Cycle Positive Regulation Of Synapse Maturation Mitotic Spindle Assembly Positive Regulation Of Ubiquitin Protein Ligase Activity Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Metaphase/anaphase Transition Of Meiosis I	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade In Utero Embryonic Development Embryonic Placenta Development DNA Repair Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II MRNA Processing Defense Response DNA Damage Response Female Meiotic Nuclear Division Spermatogenesis Response To Nutrient Cell Population Proliferation Response To Heat Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Response To Activity Negative Regulation Of Protein-containing Complex Assembly Response To Estradiol Response To Lipopolysaccharide Negative Regulation Of Tumor Necrosis Factor Production Response To Testosterone Cellular Response To Heat Cellular Response To Unfolded Protein Cellular Response To Potassium Ion Positive Regulation Of Multicellular Organism Growth Response To Amino Acid Positive Regulation Of Macrophage Differentiation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation MRNA Transport Embryonic Process Involved In Female Pregnancy Positive Regulation Of Stress Granule Assembly Protein-containing Complex Assembly Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Estradiol Stimulus Cellular Response To Xenobiotic Stimulus Cellular Response To Radiation Cellular Response To Gamma Radiation Cellular Response To Diamide Negative Regulation Of Inclusion Body Assembly Positive Regulation Of Inclusion Body Assembly Positive Regulation Of Cold-induced Thermogenesis Regulation Of Cellular Response To Heat Response To Peptide Positive Regulation Of Apoptotic DNA Fragmentation Cellular Response To Sodium Arsenite Cellular Response To Angiotensin Cellular Response To Nitroglycerin Cellular Response To L-glutamine Response To Hypobaric Hypoxia Response To Psychosocial Stress Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal APC/C:Cdc20 mediated degradation of Cyclin B SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of Emi1 APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Ub-specific processing proteases Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation Antigen processing: Ubiquitination & Proteasome degradation	Regulation of HSF1-mediated heat shock response HSF1 activation Attenuation phase HSF1-dependent transactivation Aggrephagy Mitochondrial unfolded protein response (UPRmt)
Drugs			Bimoclomol
Diseases
GWAS		Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) ( 27114598) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Dupuytren's disease ( 28886342)
Interacting Genes		53 interacting genes: ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC7 APP AURKA BUB1 BUB1B CCNA1 CCNA2 CDC16 CDC27 CDC6 CDK1 CDR2 CDT1 DCPS DTYMK EGLN3 FADD FBXO5 GMNN H2BC3 H3C1 HDAC1 HDAC2 HSF1 HSF2 KIF18A MAD2L1 MAD2L2 MCL1 MKI67 NEK2 OTUD7B PIM1 PTTG1 RASSF1 SIRT2 SOSTDC1 SPATC1 TBK1 TCP1 TGFBR1 TK1 TP63 TRAF1 TRIP13 UBC UBE2C UBE2S UBR5	53 interacting genes: CAMK2A CDC20 CDK6 CEBPB CHST10 CREBBP CSNK2A1 DAXX DNAJB1 ENO2 FILIP1 FKBP4 FKBP5 GSK3A GTF2A2 GTF2B HSBP1 HSF2 HSP90AA1 HSPA1A HSPA8 LY6E MAPK1 MAPK3 MAPK8 MAPK9 MAPKAPK2 NCOA6 OTUB1 PIM2 PPID PRKDC PTGES3 RALBP1 REPS1 RNF20 SMARCA4 STAT1 STUB1 SUB1 SUMO1 SUMO3 SYMPK TAF1 TAF7 TAF9 TBP TRRAP UBC UBE2I XRCC5 XRCC6 YWHAE
Entrez ID		991	3297
HPRD ID		04686	00778
Ensembl ID		ENSG00000117399	ENSG00000185122
Uniprot IDs		Q12834	Q00613
PDB IDs		4GGA 4GGC 4GGD 4N14 5G04 5KHR 5KHU 5LCW 6F0X 6Q6G 6Q6H 9I68 9I69 9I6A	2LDU 5D5U 5D5V 5HDG 5HDN 7DCJ 7DCS 7DCT
Enriched GO Terms of Interacting Partners?		Cell Division Regulation Of Mitotic Cell Cycle Anaphase-promoting Complex Regulation Of Chromosome Segregation Regulation Of Sister Chromatid Segregation Regulation Of Cell Cycle Regulation Of Chromosome Organization Regulation Of Nuclear Division Anaphase-promoting Complex-dependent Catabolic Process Protein K11-linked Ubiquitination Regulation Of Mitotic Nuclear Division Regulation Of Cell Cycle Process Protein Branched Polyubiquitination Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Meiotic Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Chromosome Separation Positive Regulation Of Cell Cycle Regulation Of Organelle Organization Regulation Of Reproductive Process Nucleoplasm Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Nucleus Protein Modification Process Positive Regulation Of Cell Cycle Process Mitotic Cell Cycle Phase Transition Protein K48-linked Ubiquitination Cytosol Cell Cycle Phase Transition Spindle Negative Regulation Of Mitotic Metaphase/anaphase Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Mitotic Nuclear Division Post-translational Protein Modification Positive Regulation Of Cell Cycle Phase Transition Metaphase/anaphase Transition Of Mitotic Cell Cycle Metaphase/anaphase Transition Of Cell Cycle Negative Regulation Of Cell Cycle Mitotic Spindle Negative Regulation Of Cell Cycle Process Macromolecule Metabolic Process Regulation Of Cellular Component Organization Protein Polyubiquitination Modification-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Proteasomal Protein Catabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Phase Transition	Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Cellular Response To Stress Nucleus Cellular Response To Heat Positive Regulation Of Metabolic Process Regulation Of Protein Stability Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Stabilization Enzyme Binding Regulation Of DNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Heat ATP Binding Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cytosol Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Response To Stress Transcription Factor TFIID Complex Protein Serine Kinase Activity Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Transcription Preinitiation Complex Assembly Regulation Of Gene Expression DNA Damage Response Heat Shock Protein Binding Nucleic Acid Metabolic Process Ubiquitin Protein Ligase Binding Macromolecule Metabolic Process RNA Polymerase II General Transcription Initiation Factor Activity Protein Serine/threonine Kinase Activity DNA-templated Transcription Initiation Nucleobase-containing Compound Metabolic Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding Negative Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Protein Modification Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process RNA Polymerase II Preinitiation Complex Assembly
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