DTYMK and DHFR

		DTYMK	DHFR
Description		deoxythymidylate kinase	dihydrofolate reductase
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol	Cytoplasm Mitochondrion Cytosol
	Molecular Function	Nucleotide Binding Nucleoside Diphosphate Kinase Activity DTMP Kinase Activity ATP Binding Kinase Activity Transferase Activity	MRNA Regulatory Element Binding Translation Repressor Activity RNA Binding MRNA Binding Dihydrofolate Reductase Activity Protein Binding Folic Acid Binding Oxidoreductase Activity NADP Binding NADPH Binding Sequence-specific MRNA Binding
	Biological Process	DUDP Biosynthetic Process DTDP Biosynthetic Process DTTP Biosynthetic Process Nucleotide Biosynthetic Process Thymidine Biosynthetic Process Cellular Response To Growth Factor Stimulus	Tetrahydrobiopterin Biosynthetic Process One-carbon Metabolic Process Negative Regulation Of Translation Axon Regeneration Response To Methotrexate Dihydrofolate Metabolic Process Tetrahydrofolate Metabolic Process Tetrahydrofolate Biosynthetic Process Folic Acid Metabolic Process Regulation Of Removal Of Superoxide Radicals
Pathways		Interconversion of nucleotide di- and triphosphates	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Metabolism of folate and pterines G1/S-Specific Transcription
Drugs		Thymidine monophosphate 2',3'-Dideoxythymidine-5'-Monophosphate 3'-Fluoro-3'-deoxythymidine 5'-monophosphate 3'-deoxy-3'-aminothymidine monophosphate p1-(5'-adenosyl)p5-(5'-thymidyl)pentaphosphate Zidovudine monophosphate P1-(5'-Adenosyl)P5-(5'-(3'azido-3'-Deoxythymidyl))Pentaphosphate Phosphoaminophosphonic Acid-Adenylate Ester	NADH Pyrimethamine Methotrexate Pemetrexed Gentamicin Proguanil Trimetrexate 2,4-Diamino-5-Methyl-6-[(3,4,5-Trimethoxy-N-Methylanilino)Methyl]Pyrido[2,3-D]Pyrimidine 2,4-Diamino-6-[N-(2',5'-Dimethoxybenzyl)-N-Methylamino]Quinazoline 6-(Octahydro-1h-Indol-1-Ylmethyl)Decahydroquinazoline-2,4-Diamine N6-(2,5-Dimethoxy-Benzyl)-N6-Methyl-Pyrido[2,3-D]Pyrimidine-2,4,6-Triamine 2,4-Diamino-6-[N-(3',4',5'-Trimethoxybenzyl)-N-Methylamino]Pyrido[2,3-D]Pyrimidine Sri-9662 2,4-Diamino-5-(3,4,5-Trimethoxy-Benzyl)-Pyrimidin-1-Ium Sri-9439 Nicotinamide adenine dinucleotide phosphate Piritrexim Biopterin 2,4-Diamino-6-[N-(3',5'-Dimethoxybenzyl)-N-Methylamino]Pyrido[2,3-D]Pyrimidine Iclaprim Pralatrexate 5-[(3R)-3-(5-methoxybiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine 5-[(3R)-3-(5-methoxy-4'-methylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine 5-[(3R)-3-(5-methoxy-3',5'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine 5-[(3R)-3-(5-methoxy-2',6'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine 5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine [N-(2,4-DIAMINOPTERIDIN-6-YL)-METHYL]-DIBENZ[B,F]AZEPINE (4aS)-5-[(2,4-diaminopteridin-6-yl)methyl]-4a,5-dihydro-2H-dibenzo[b,f]azepin-8-ol (2R,6S)-6-{[methyl(3,4,5-trimethoxyphenyl)amino]methyl}-1,2,5,6,7,8-hexahydroquinazoline-2,4-diamine
Diseases
GWAS		Asthma ( 31959851) Diverticular disease ( 30177863) Prostate cancer ( 23535732)	Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness ( 32963231) Glomerular filtration rate (creatinine) ( 26831199) Huntington's disease progression ( 28642124) Idiopathic downbeat nystagmus ( 32157568) Shingles ( 25297839) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		5 interacting genes: CDC20 CEBPA DHFR FZR1 HSD17B7	18 interacting genes: - AMFR ASGR1 CDC42 COPS8 CRHBP DTYMK EXOC4 FKBP1A GKAP1 HSPD1 MDM2 RAE1 RHOQ THBS1 TOMM20 TOMM7 TP53
Entrez ID		1841	1719
HPRD ID		01773	00519
Ensembl ID		ENSG00000168393	ENSG00000228716
Uniprot IDs		P23919 Q53F55 Q6FGU2	B0YJ76 B4DM58 P00374
PDB IDs		1E2D 1E2E 1E2F 1E2G 1E2Q 1E98 1E99 1E9A 1E9B 1E9C 1E9D 1E9E 1E9F 1NMX 1NMY 1NMZ 1NN0 1NN1 1NN3 1NN5 2XX3	1BOZ 1DHF 1DLR 1DLS 1DRF 1HFP 1HFQ 1HFR 1KMS 1KMV 1MVS 1MVT 1OHJ 1OHK 1PD8 1PD9 1PDB 1S3U 1S3V 1S3W 1U71 1U72 1YHO 2C2S 2C2T 2DHF 2W3A 2W3B 2W3M 3EIG 3F8Y 3F8Z 3F91 3FS6 3GHC 3GHV 3GHW 3GI2 3GYF 3L3R 3N0H 3NTZ 3NU0 3NXO 3NXR 3NXT 3NXV 3NXX 3NXY 3NZD 3OAF 3S3V 3S7A 4DDR 4G95 4KAK 4KBN 4KD7 4KEB 4KFJ 4M6J 4M6K 4M6L 4QHV 4QJC 5HPB 5HQY 5HQZ 5HSR 5HSU 5HT4 5HT5 5HUI 5HVB 5HVE 5SD6 5SD7 5SD8 5SD9 5SDA 5SDB 6A7C 6A7E 6DAV 6DE4 6VCJ 7ESE 7XI7 8WGN
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Anaphase-promoting Complex Binding Ubiquitin-protein Transferase Activator Activity Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ubiquitin Ligase Activator Activity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Protein Catabolic Process Anaphase-promoting Complex Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Meiotic Nuclear Division Alcohol Metabolic Process Negative Regulation Of Cell Cycle Regulation Of Protein Catabolic Process Regulation Of Proteolysis Regulation Of Meiotic Cell Cycle Small Molecule Biosynthetic Process Small Molecule Metabolic Process Regulation Of Protein Metabolic Process Metaphase/anaphase Transition Of Meiosis I RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Methotrexate Positive Regulation Of Catabolic Process Ubiquitin-like Ligase-substrate Adaptor Activity Positive Regulation Of Protein Ubiquitination Cholesterol Metabolic Process Positive Regulation Of Post-translational Protein Modification Histone Deacetylase Binding Sterol Metabolic Process Regeneration Response To Vitamin B2 C/EBP Complex Dihydrofolate Reductase Activity Regulation Of Nuclear Division CHOP-C/EBP Complex Embryonic Organ Development Dihydrofolate Metabolic Process DNA Synthesis Involved In Mitotic DNA Replication Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Protein Metabolic Process Meiotic Cell Cycle Phase Transition	GBD Domain Binding Protein Transmembrane Transport Cellular Response To Actinomycin D Migrasome Response To Actinomycin D Protein Localization To Mitochondrion Cellular Response To UV-C Intracellular Signaling Cassette TOM Complex Membrane Organization Mitochondrial Outer Membrane Translocase Complex 'de Novo' Protein Folding Cellular Response To Antibiotic P53 Binding Establishment Of Protein Localization To Mitochondrion Protein Insertion Into Mitochondrial Outer Membrane Response To UV-C Protein-folding Chaperone Binding Ubiquitin Binding Cellular Response To Estrogen Stimulus Secretory Granule Mitochondrion Organization Response To Magnesium Ion Intracellular Signal Transduction Response To Xenobiotic Stimulus Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Protein Processing Mitochondrial Membrane Organization Negative Regulation Of Protein Maturation Protein Import Into Mitochondrial Matrix Positive Regulation Of Filopodium Assembly Amyloid Fibril Formation Protein Refolding Protein Localization To Organelle Positive Regulation Of Macrophage Activation Establishment Of Protein Localization To Organelle Cellular Response To Gamma Radiation Disordered Domain Specific Binding Negative Regulation Of Proteolysis CGMP-mediated Signaling Protein Transmembrane Transporter Activity Phagocytosis, Engulfment Protein Insertion Into Mitochondrial Membrane Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Stability Establishment Of Protein Localization To Mitochondrial Membrane Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Antibiotic Protein-containing Complex Regulation Of Filopodium Assembly
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