WWP2 and OPTN

Number of citations of the paper that reports this interaction (PubMedID 35331737)
83

Data Source:
BioGRID (pull down)

		WWP2	OPTN
Description		WW domain containing E3 ubiquitin protein ligase 2	optineurin
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Membrane Extracellular Exosome	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Endosome Autophagosome Golgi Apparatus Trans-Golgi Network Cytosol Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Transferase Activity Potassium Channel Inhibitor Activity Transmembrane Transporter Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Ubiquitin Protein Ligase Activity Transcription Regulator Inhibitor Activity	Protein Binding Zinc Ion Binding Protein-macromolecule Adaptor Activity Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Extracellular Transport Negative Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Transporter Activity Regulation Of Monoatomic Ion Transmembrane Transport Protein Modification Process Regulation Of Membrane Potential Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Notch Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Symbiont Entry Into Host Cell Negative Regulation Of Protein Transport Protein Autoubiquitination Protein K63-linked Ubiquitination Negative Regulation Of Potassium Ion Export Across Plasma Membrane	Negative Regulation Of Receptor Recycling Immune System Process Autophagy Golgi Organization Signal Transduction Intracellular Protein Localization Cell Death Positive Regulation Of Autophagy Protein Localization To Golgi Apparatus Cellular Response To Unfolded Protein Golgi To Plasma Membrane Protein Transport Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Defense Response To Gram-negative Bacterium Type 2 Mitophagy Golgi Ribbon Formation Positive Regulation Of Xenophagy
Pathways		Regulation of PTEN stability and activity RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle NOTCH3 Activation and Transmission of Signal to the Nucleus	Regulation of PLK1 Activity at G2/M Transition PINK1-PRKN Mediated Mitophagy TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TBC/RABGAPs TICAM1-dependent activation of IRF3/IRF7 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
Drugs
Diseases			Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Primary open angle glaucoma
GWAS		Appendicular lean mass ( 33097823) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Cataracts ( 34127677) Cataracts (operation) ( 31816047) Diastolic blood pressure ( 30578418) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31152163) FEV1 ( 30804560) Hand grip strength ( 29691431) Height ( 31562340 28552196) IgE levels ( 23146381) Knee osteoarthritis ( 30374069) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Lung function (FVC) ( 30804560) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Menarche (age at onset) ( 25231870) Myocardial infarction ( 33532862) Plantar fascial disorders ( 29534260) Platelet count ( 32888494) Pulse pressure ( 30578418) Smoking behaviour (cigarette pack-years) ( 30679032) Smoking initiation ( 33082346) Triglyceride levels ( 31928498) Triglycerides ( 30275531) Waist circumference ( 31928498)	Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Paget's disease ( 20436471 21623375)
Interacting Genes		118 interacting genes: ANKRD44 ARRDC3 ATN1 ATOSB ATXN3 C3orf70 CALCOCO2 CDC34 CFAP36 CFTR CLCN5 CPSF6 DAG1 DIDO1 DVL2 EFCAB3 EGR2 ENTREP1 EWSR1 FAF1 FAM131B FAM131C FBXL18 FUT3 GADD45GIP1 GAS2L2 GGN GRAP2 HGS HNRNPUL1 IFIT2 IL2RG IL6R IST1 KHDRBS3 LGALS9B MED25 MED4 MIR19A MIR19B1 MIR92A1 NDFIP1 NDFIP2 NHERF2 NOTCH4 NUTF2 OPTN PAIP1 PATZ1 PDCD6IP PDLIM7 PLA2G15 PRKAA2 PSMD4 PSMF1 PTEN RABEP2 RAD23A RAD23B RASA1 RASD1 RNF11 RUSC1 SCAMP3 SCN5A SCNN1A SCNN1B SCNN1G SEC24D SF1 SFMBT1 SFTPC SMAD3 SMAD7 SMR3A SNRPB SNRPC SOX2 SPART SQSTM1 STAM TFAP2A THBS1 TICAM1 TNK2 TOM1 TOM1L2 TP53BP2 TRAF4 TRIP10 UBAC1 UBAP1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2J2 UBE2K UBE2L3 UBL7 UBQLN1 UBQLN4 UBTD1 USP5 USP7 VASP VPS37C WASF2 WBP1 WBP2 WDR5 WIPF1 ZNF688	73 interacting genes: AIMP1 ARRDC3 ATG16L1 ATG5 CALM1 CCDC13 CDC23 CDK4 CFTR CLTC CMYA5 DAZAP2 DYSF DZIP1 ENTREP1 FLII FOS FTH1 GABARAP GABARAPL1 GABARAPL2 GNAS GRM1 GTF3A HACE1 HSF2BP HSPB1 HTT IRAK1 KANSL1L LITAF LNX2 MAILR MAP1LC3A MAP1LC3B MAP1LC3C MPP1 MYH3 MYO6 PIAS4 PICK1 POU6F2 RAB11A RAB11B RAB12 RAB14 RAB25 RAB8A RBM12 RFFL RNF11 RNF216 SDCBP SLF2 SNCA SNX6 TBC1D15 TBC1D17 UBB UQCRQ USP2 VCP WASHC3 WIPI2 WWP2 ZNF17 ZNF181 ZNF302 ZNF329 ZNF398 ZNF426 ZNF670 ZNF711
Entrez ID		11060	10133
HPRD ID		03812	03891
Ensembl ID		ENSG00000198373	ENSG00000123240
Uniprot IDs		B4DHF6 O00308	Q96CV9
PDB IDs		4Y07 5TJ7 5TJ8 5TJQ 6J1Z 6RSS 8EI5 8EI6 8EI7 8EI8 9EQH	2LO4 2LUE 3VTV 3VTW 5AAZ 5B83 5EOA 5EOF 7CZM 9B0B 9B0Z 9B12 9IKQ
Enriched GO Terms of Interacting Partners?		Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Proteolysis WW Domain Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Macromolecule Catabolic Process Ubiquitin Binding Protein Polyubiquitination Protein Modification By Small Protein Conjugation Endosome Catabolic Process Nucleoplasm Protein Ubiquitination Cytosol Post-translational Protein Modification Protein K48-linked Ubiquitination Multivesicular Body Assembly Multivesicular Body Organization Protein Metabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Binding Sensory Perception Of Salty Taste Regulation Of Proteasomal Protein Catabolic Process Endosome Organization Macroautophagy Regulation Of Proteolysis Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Metabolic Process Proteasomal Protein Catabolic Process Protein Catabolic Process Perinuclear Region Of Cytoplasm Proteasome Binding Autophagy Protein K11-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Ubiquitin-protein Transferase Activity Cellular Response To Aldosterone Sodium Channel Complex Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process	Autophagosome Cellular Response To Nitrogen Starvation Cytoplasmic Vesicle Phosphatidylethanolamine Binding Autophagy Autophagosome Maturation Endosome Autophagosome Assembly Ubiquitin Protein Ligase Binding Autophagosome Organization Autophagy Of Mitochondrion Establishment Of Protein Localization Macroautophagy Protein Transport Phospholipid Binding Autophagosome Membrane Vacuole Organization Mitophagy Myosin V Binding Cellular Response To Starvation Establishment Of Localization In Cell Recycling Endosome Membrane Protein-containing Complex Disassembly Response To Starvation Organelle Assembly Intracellular Transport Recycling Endosome Cellular Response To Nutrient Levels Intracellular Protein Localization Endosomal Transport Cellular Localization Lysosome Beta-tubulin Binding Centriolar Satellite Amyloid-beta Clearance By Transcytosis Response To Iron(II) Ion Regulation Of Cilium Assembly Vesicle-mediated Transport Cellular Response To Stress Cytoplasmic Vesicle Membrane Cytosol G Protein Activity Cytoplasm Intracellular Protein Transport Endocytic Recycling Regulation Of Protein Localization Exocytosis Endosome Membrane Catabolic Process Response To Nutrient Levels
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