OPTN and HACE1

Number of citations of the paper that reports this interaction (PubMedID 25026213)
49

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		OPTN	HACE1
Description		optineurin	HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
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GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Endosome Autophagosome Golgi Apparatus Trans-Golgi Network Cytosol Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane	Golgi Membrane Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Membrane Nuclear Body Golgi Cisterna Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Protein-macromolecule Adaptor Activity Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Small GTPase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Receptor Recycling Immune System Process Autophagy Golgi Organization Signal Transduction Intracellular Protein Localization Cell Death Positive Regulation Of Autophagy Protein Localization To Golgi Apparatus Cellular Response To Unfolded Protein Golgi To Plasma Membrane Protein Transport Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Defense Response To Gram-negative Bacterium Type 2 Mitophagy Golgi Ribbon Formation Positive Regulation Of Xenophagy	Ubiquitin-dependent Protein Catabolic Process Golgi Organization Protein Ubiquitination Rac Protein Signal Transduction Regulation Of Cell Migration Membrane Fusion Protein K48-linked Ubiquitination
Pathways		Regulation of PLK1 Activity at G2/M Transition PINK1-PRKN Mediated Mitophagy TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TBC/RABGAPs TICAM1-dependent activation of IRF3/IRF7 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Primary open angle glaucoma
GWAS		Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Paget's disease ( 20436471 21623375)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Age at voice drop ( 27182965) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Feeling guilty ( 29500382) Height ( 18391951) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 29617998) Major depressive disorder ( 27479909) Menarche (age at onset) ( 27182965 19448622) Multiple sclerosis ( 23412934) Neuroblastoma ( 22941191) Obsessive-compulsive disorder ( 22889921) Resistant hypertension ( 31545351) Schizophrenia ( 28991256) Sporadic neuroblastoma ( 28545128) Thyroid stimulating hormone levels ( 17903292) Type 2 diabetes ( 31049640) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in inactive individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500)
Interacting Genes		73 interacting genes: AIMP1 ARRDC3 ATG16L1 ATG5 CALM1 CCDC13 CDC23 CDK4 CFTR CLTC CMYA5 DAZAP2 DYSF DZIP1 ENTREP1 FLII FOS FTH1 GABARAP GABARAPL1 GABARAPL2 GNAS GRM1 GTF3A HACE1 HSF2BP HSPB1 HTT IRAK1 KANSL1L LITAF LNX2 MAILR MAP1LC3A MAP1LC3B MAP1LC3C MPP1 MYH3 MYO6 PIAS4 PICK1 POU6F2 RAB11A RAB11B RAB12 RAB14 RAB25 RAB8A RBM12 RFFL RNF11 RNF216 SDCBP SLF2 SNCA SNX6 TBC1D15 TBC1D17 UBB UQCRQ USP2 VCP WASHC3 WIPI2 WWP2 ZNF17 ZNF181 ZNF302 ZNF329 ZNF398 ZNF426 ZNF670 ZNF711	10 interacting genes: CCNC MTDH OPTN PAK1 PLXNA2 RAB4A RAC1 SNTG2 UBE2D2 UBE2L3
Entrez ID		10133	57531
HPRD ID		03891	17086
Ensembl ID		ENSG00000123240	ENSG00000085382
Uniprot IDs		Q96CV9	Q8IYU2
PDB IDs		2LO4 2LUE 3VTV 3VTW 5AAZ 5B83 5EOA 5EOF 7CZM 9B0B 9B0Z 9B12 9IKQ	8H8X 8HAE 8PWL 8Q0N
Enriched GO Terms of Interacting Partners?		Autophagosome Cellular Response To Nitrogen Starvation Cytoplasmic Vesicle Phosphatidylethanolamine Binding Autophagy Autophagosome Maturation Endosome Autophagosome Assembly Ubiquitin Protein Ligase Binding Autophagosome Organization Autophagy Of Mitochondrion Establishment Of Protein Localization Macroautophagy Protein Transport Phospholipid Binding Autophagosome Membrane Vacuole Organization Mitophagy Myosin V Binding Cellular Response To Starvation Establishment Of Localization In Cell Recycling Endosome Membrane Protein-containing Complex Disassembly Response To Starvation Organelle Assembly Intracellular Transport Recycling Endosome Cellular Response To Nutrient Levels Intracellular Protein Localization Endosomal Transport Cellular Localization Lysosome Beta-tubulin Binding Centriolar Satellite Amyloid-beta Clearance By Transcytosis Response To Iron(II) Ion Regulation Of Cilium Assembly Vesicle-mediated Transport Cellular Response To Stress Cytoplasmic Vesicle Membrane Cytosol G Protein Activity Cytoplasm Intracellular Protein Transport Endocytic Recycling Regulation Of Protein Localization Exocytosis Endosome Membrane Catabolic Process Response To Nutrient Levels	Hepatocyte Growth Factor Receptor Signaling Pathway Recycling Endosome Membrane Regulation Of Fibroblast Migration Positive Regulation Of Microtubule Polymerization Semaphorin-plexin Signaling Pathway Ubiquitin Conjugating Enzyme Activity Positive Regulation Of Protein Polymerization Regulation Of Microtubule Polymerization Positive Regulation Of Stress Fiber Assembly Actin Filament Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Actin Filament Bundle Assembly Cerebellar Granule Cell Precursor Tangential Migration G Protein Activity Neurotransmitter Receptor Transport Postsynaptic Membrane To Endosome Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Nucleotide Binding Regulation Of Microtubule Polymerization Or Depolymerization Ruffle Membrane Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Regulation Of Stress Fiber Assembly Rho GDP-dissociation Inhibitor Binding Regulation Of Cell Adhesion Involved In Heart Morphogenesis
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