OPTN and GABARAPL2

Number of citations of the paper that reports this interaction (PubMedID 37219487)
66

Data Source:
BioGRID (unspecified method)

		OPTN	GABARAPL2
Description		optineurin	GABA type A receptor associated protein like 2
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GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Endosome Autophagosome Golgi Apparatus Trans-Golgi Network Cytosol Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane	Golgi Membrane Autophagosome Membrane Cytoplasm Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Cytoplasmic Vesicle
	Molecular Function	Protein Binding Zinc Ion Binding Protein-macromolecule Adaptor Activity Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	SNARE Binding Protein Binding Phospholipid Binding Microtubule Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding ATPase Binding
	Biological Process	Negative Regulation Of Receptor Recycling Immune System Process Autophagy Golgi Organization Signal Transduction Intracellular Protein Localization Cell Death Positive Regulation Of Autophagy Protein Localization To Golgi Apparatus Cellular Response To Unfolded Protein Golgi To Plasma Membrane Protein Transport Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Defense Response To Gram-negative Bacterium Type 2 Mitophagy Golgi Ribbon Formation Positive Regulation Of Xenophagy	Autophagosome Assembly Mitophagy Intra-Golgi Vesicle-mediated Transport Autophagy Cellular Response To Nitrogen Starvation Protein Transport Positive Regulation Of ATP-dependent Activity Protein Localization To Endoplasmic Reticulum Autophagosome Maturation Negative Regulation Of Proteasomal Protein Catabolic Process
Pathways		Regulation of PLK1 Activity at G2/M Transition PINK1-PRKN Mediated Mitophagy TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TBC/RABGAPs TICAM1-dependent activation of IRF3/IRF7 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	Macroautophagy TBC/RABGAPs
Drugs
Diseases		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Primary open angle glaucoma
GWAS		Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Paget's disease ( 20436471 21623375)	Age at first sexual intercourse ( 34211149) Blood protein levels ( 30072576) Pancreatic cancer ( 25086665)
Interacting Genes		73 interacting genes: AIMP1 ARRDC3 ATG16L1 ATG5 CALM1 CCDC13 CDC23 CDK4 CFTR CLTC CMYA5 DAZAP2 DYSF DZIP1 ENTREP1 FLII FOS FTH1 GABARAP GABARAPL1 GABARAPL2 GNAS GRM1 GTF3A HACE1 HSF2BP HSPB1 HTT IRAK1 KANSL1L LITAF LNX2 MAILR MAP1LC3A MAP1LC3B MAP1LC3C MPP1 MYH3 MYO6 PIAS4 PICK1 POU6F2 RAB11A RAB11B RAB12 RAB14 RAB25 RAB8A RBM12 RFFL RNF11 RNF216 SDCBP SLF2 SNCA SNX6 TBC1D15 TBC1D17 UBB UQCRQ USP2 VCP WASHC3 WIPI2 WWP2 ZNF17 ZNF181 ZNF302 ZNF329 ZNF398 ZNF426 ZNF670 ZNF711	105 interacting genes: AAMP AGTRAP AHNAK2 AMBRA1 ANK2 APP APPL1 ARFGAP1 ATG13 ATG3 ATG4A ATG4B ATG4D ATG7 AZI2 BCL2L13 BICC1 BNIP3L BRD9 BSDC1 CALCOCO1 CALCOCO2 CARS2 CDC37 CEBPA CLN8 CUL3 DYNLL1 DYNLL2 EGFR ERBB2 ERBB3 ERBB4 FUNDC1 GIMAP6 GOSR1 GPM6A GPR37 HAP1 INSYN1 KASH5 KBTBD6 KBTBD7 KIAA1958 KIF16B KLHL5 KRTAP10-7 KRTAP10-9 LRSAM1 LZTR1 MAP4K2 MCPH1 MEF2A MEFV MLX MRPL49 MYBPC1 NBR1 NCOR1 NEDD4 NPSR1 NSF NUDT15 OPTN OSBPL3 OSBPL7 PDLIM1 PRKAR2A PTPRA RAP1A RAP2A RB1CC1 RCN2 RESF1 RETREG1 RETREG3 RPS2 SCYL3 SEPTIN3 SGTA SIK2 SMO SQSTM1 TAX1BP1 TBC1D25 TBC1D5 TBC1D9 TBC1D9B TEX264 TNIP1 TP53INP1 TP53INP2 TRIM21 TRIM25 TRIM32 TRIM45 TSR2 UBA5 ULK1 ULK2 VDR WDFY3 YWHAZ ZBTB2 ZNF774
Entrez ID		10133	11345
HPRD ID		03891	16246
Ensembl ID		ENSG00000123240	ENSG00000034713
Uniprot IDs		Q96CV9	P60520
PDB IDs		2LO4 2LUE 3VTV 3VTW 5AAZ 5B83 5EOA 5EOF 7CZM 9B0B 9B0Z 9B12 9IKQ	4CO7 6H8C 7LK3 7YO8 8Q6Q
Enriched GO Terms of Interacting Partners?		Autophagosome Cellular Response To Nitrogen Starvation Cytoplasmic Vesicle Phosphatidylethanolamine Binding Autophagy Autophagosome Maturation Endosome Autophagosome Assembly Ubiquitin Protein Ligase Binding Autophagosome Organization Autophagy Of Mitochondrion Establishment Of Protein Localization Macroautophagy Protein Transport Phospholipid Binding Autophagosome Membrane Vacuole Organization Mitophagy Myosin V Binding Cellular Response To Starvation Establishment Of Localization In Cell Recycling Endosome Membrane Protein-containing Complex Disassembly Response To Starvation Organelle Assembly Intracellular Transport Recycling Endosome Cellular Response To Nutrient Levels Intracellular Protein Localization Endosomal Transport Cellular Localization Lysosome Beta-tubulin Binding Centriolar Satellite Amyloid-beta Clearance By Transcytosis Response To Iron(II) Ion Regulation Of Cilium Assembly Vesicle-mediated Transport Cellular Response To Stress Cytoplasmic Vesicle Membrane Cytosol G Protein Activity Cytoplasm Intracellular Protein Transport Endocytic Recycling Regulation Of Protein Localization Exocytosis Endosome Membrane Catabolic Process Response To Nutrient Levels	Autophagosome Autophagy Macroautophagy Autophagy Of Mitochondrion Mitophagy Autophagosome Assembly Autophagosome Organization Catabolic Process Nucleophagy Vacuole Organization Piecemeal Microautophagy Of The Nucleus Phagophore Assembly Site Microautophagy Positive Regulation Of Autophagy Regulation Of Autophagy Positive Regulation Of Catabolic Process Cytosol Reticulophagy Cytoplasm Aggrephagy Cytoplasmic Vesicle Intracellular Protein Localization Organelle Assembly Atg1/ULK1 Kinase Complex Organelle Organization Positive Regulation Of Macroautophagy Protein Polyubiquitination Regulation Of Intracellular Signal Transduction Regulation Of Macroautophagy Protein-phosphatidylethanolamide Deconjugating Activity Autophagosome Membrane Macromolecule Catabolic Process Response To Stress Regulation Of Signal Transduction Protein Delipidation Regulation Of Signaling Receptor Complex Protein Modification Process Protein K48-linked Ubiquitination Response To Mitochondrial Depolarisation Protein Modification By Small Protein Conjugation Positive Regulation Of Metabolic Process Regulation Of Cell Communication Establishment Of Protein Localization Protein Binding Phagophore Assembly Site Membrane ERBB2 Signaling Pathway Regulation Of MAPK Cascade Protein Metabolic Process Identical Protein Binding
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