OPTN and RAB12

Number of citations of the paper that reports this interaction (PubMedID 23357852)
61

Data Source:
BioGRID (two hybrid)

		OPTN	RAB12
Description		optineurin	RAB12, member RAS oncogene family
Image
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Endosome Autophagosome Golgi Apparatus Trans-Golgi Network Cytosol Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane	Golgi Membrane Cytoplasm Lysosome Lysosomal Membrane Endosome Autophagosome Golgi Apparatus Cytosol Plasma Membrane Synaptic Vesicle Membrane Trans-Golgi Network Transport Vesicle Cytoplasmic Vesicle Recycling Endosome Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Protein-macromolecule Adaptor Activity Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Receptor Recycling Immune System Process Autophagy Golgi Organization Signal Transduction Intracellular Protein Localization Cell Death Positive Regulation Of Autophagy Protein Localization To Golgi Apparatus Cellular Response To Unfolded Protein Golgi To Plasma Membrane Protein Transport Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Defense Response To Gram-negative Bacterium Type 2 Mitophagy Golgi Ribbon Formation Positive Regulation Of Xenophagy	Exocytosis Autophagy Endosome To Lysosome Transport Protein Transport Protein Catabolic Process Endocytic Recycling Rab Protein Signal Transduction
Pathways		Regulation of PLK1 Activity at G2/M Transition PINK1-PRKN Mediated Mitophagy TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TBC/RABGAPs TICAM1-dependent activation of IRF3/IRF7 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Primary open angle glaucoma
GWAS		Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Paget's disease ( 20436471 21623375)	Metabolite levels ( 23823483) Risk-taking tendency (4-domain principal component model) ( 30643258)
Interacting Genes		73 interacting genes: AIMP1 ARRDC3 ATG16L1 ATG5 CALM1 CCDC13 CDC23 CDK4 CFTR CLTC CMYA5 DAZAP2 DYSF DZIP1 ENTREP1 FLII FOS FTH1 GABARAP GABARAPL1 GABARAPL2 GNAS GRM1 GTF3A HACE1 HSF2BP HSPB1 HTT IRAK1 KANSL1L LITAF LNX2 MAILR MAP1LC3A MAP1LC3B MAP1LC3C MPP1 MYH3 MYO6 PIAS4 PICK1 POU6F2 RAB11A RAB11B RAB12 RAB14 RAB25 RAB8A RBM12 RFFL RNF11 RNF216 SDCBP SLF2 SNCA SNX6 TBC1D15 TBC1D17 UBB UQCRQ USP2 VCP WASHC3 WIPI2 WWP2 ZNF17 ZNF181 ZNF302 ZNF329 ZNF398 ZNF426 ZNF670 ZNF711	1 interacting genes: OPTN
Entrez ID		10133	201475
HPRD ID		03891	18749
Ensembl ID		ENSG00000123240	ENSG00000206418
Uniprot IDs		Q96CV9	A0A3B3ITT1 Q6IQ22
PDB IDs		2LO4 2LUE 3VTV 3VTW 5AAZ 5B83 5EOA 5EOF 7CZM 9B0B 9B0Z 9B12 9IKQ	2IL1 8VH4 8VH5
Enriched GO Terms of Interacting Partners?		Autophagosome Cellular Response To Nitrogen Starvation Cytoplasmic Vesicle Phosphatidylethanolamine Binding Autophagy Autophagosome Maturation Endosome Autophagosome Assembly Ubiquitin Protein Ligase Binding Autophagosome Organization Autophagy Of Mitochondrion Establishment Of Protein Localization Macroautophagy Protein Transport Phospholipid Binding Autophagosome Membrane Vacuole Organization Mitophagy Myosin V Binding Cellular Response To Starvation Establishment Of Localization In Cell Recycling Endosome Membrane Protein-containing Complex Disassembly Response To Starvation Organelle Assembly Intracellular Transport Recycling Endosome Cellular Response To Nutrient Levels Intracellular Protein Localization Endosomal Transport Cellular Localization Lysosome Beta-tubulin Binding Centriolar Satellite Amyloid-beta Clearance By Transcytosis Response To Iron(II) Ion Regulation Of Cilium Assembly Vesicle-mediated Transport Cellular Response To Stress Cytoplasmic Vesicle Membrane Cytosol G Protein Activity Cytoplasm Intracellular Protein Transport Endocytic Recycling Regulation Of Protein Localization Exocytosis Endosome Membrane Catabolic Process Response To Nutrient Levels	Positive Regulation Of Xenophagy Negative Regulation Of Receptor Recycling Golgi Ribbon Formation Type 2 Mitophagy Cellular Response To Unfolded Protein Protein Localization To Golgi Apparatus Cellular Response To Topologically Incorrect Protein K63-linked Polyubiquitin Modification-dependent Protein Binding Regulation Of Receptor Recycling Golgi To Plasma Membrane Protein Transport Polyubiquitin Modification-dependent Protein Binding Mitophagy Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Negative Regulation Of Canonical NF-kappaB Signal Transduction Autophagosome Response To Unfolded Protein Positive Regulation Of Macroautophagy Post-Golgi Vesicle-mediated Transport Defense Response To Gram-negative Bacterium Autophagy Of Mitochondrion Recycling Endosome Membrane Golgi Organization Vesicle-mediated Transport To The Plasma Membrane Recycling Endosome Macroautophagy Positive Regulation Of Autophagy Protein Localization To Plasma Membrane Trans-Golgi Network Regulation Of Macroautophagy Establishment Of Protein Localization To Membrane Protein-macromolecule Adaptor Activity Protein Localization To Cell Periphery
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?