WWP2 and UBE2E3

Number of citations of the paper that reports this interaction (PubMedID 22496338)
65

Data Source:
BioGRID (two hybrid, pull down)

		WWP2	UBE2E3
Description		WW domain containing E3 ubiquitin protein ligase 2	ubiquitin conjugating enzyme E2 E3
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Membrane Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Transferase Activity Potassium Channel Inhibitor Activity Transmembrane Transporter Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Ubiquitin Protein Ligase Activity Transcription Regulator Inhibitor Activity	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Extracellular Transport Negative Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Transporter Activity Regulation Of Monoatomic Ion Transmembrane Transport Protein Modification Process Regulation Of Membrane Potential Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Notch Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Symbiont Entry Into Host Cell Negative Regulation Of Protein Transport Protein Autoubiquitination Protein K63-linked Ubiquitination Negative Regulation Of Potassium Ion Export Across Plasma Membrane	Protein Monoubiquitination Negative Regulation Of Gene Expression Protein Ubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination
Pathways		Regulation of PTEN stability and activity RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle NOTCH3 Activation and Transmission of Signal to the Nucleus	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Cataracts ( 34127677) Cataracts (operation) ( 31816047) Diastolic blood pressure ( 30578418) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31152163) FEV1 ( 30804560) Hand grip strength ( 29691431) Height ( 31562340 28552196) IgE levels ( 23146381) Knee osteoarthritis ( 30374069) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Lung function (FVC) ( 30804560) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Menarche (age at onset) ( 25231870) Myocardial infarction ( 33532862) Plantar fascial disorders ( 29534260) Platelet count ( 32888494) Pulse pressure ( 30578418) Smoking behaviour (cigarette pack-years) ( 30679032) Smoking initiation ( 33082346) Triglyceride levels ( 31928498) Triglycerides ( 30275531) Waist circumference ( 31928498)	Ankylosing spondylitis ( 23749187) Basophil count ( 32888494) Body mass index ( 25673413) Celiac disease ( 22057235 20190752) Celiac disease and Rheumatoid arthritis ( 26546613) Heel bone mineral density ( 30598549) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lymphocyte count ( 29403010) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Number of sexual partners ( 30643258) Obesity ( 21552555) QT interval ( 29213071) Red blood cell count ( 27863252 32888494) Risk-taking tendency (4-domain principal component model) ( 30643258) Serum alkaline phosphatase levels ( 33547301) Sweet taste preference ( 32572145) White blood cell count ( 27863252)
Interacting Genes		118 interacting genes: ANKRD44 ARRDC3 ATN1 ATOSB ATXN3 C3orf70 CALCOCO2 CDC34 CFAP36 CFTR CLCN5 CPSF6 DAG1 DIDO1 DVL2 EFCAB3 EGR2 ENTREP1 EWSR1 FAF1 FAM131B FAM131C FBXL18 FUT3 GADD45GIP1 GAS2L2 GGN GRAP2 HGS HNRNPUL1 IFIT2 IL2RG IL6R IST1 KHDRBS3 LGALS9B MED25 MED4 MIR19A MIR19B1 MIR92A1 NDFIP1 NDFIP2 NHERF2 NOTCH4 NUTF2 OPTN PAIP1 PATZ1 PDCD6IP PDLIM7 PLA2G15 PRKAA2 PSMD4 PSMF1 PTEN RABEP2 RAD23A RAD23B RASA1 RASD1 RNF11 RUSC1 SCAMP3 SCN5A SCNN1A SCNN1B SCNN1G SEC24D SF1 SFMBT1 SFTPC SMAD3 SMAD7 SMR3A SNRPB SNRPC SOX2 SPART SQSTM1 STAM TFAP2A THBS1 TICAM1 TNK2 TOM1 TOM1L2 TP53BP2 TRAF4 TRIP10 UBAC1 UBAP1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2J2 UBE2K UBE2L3 UBL7 UBQLN1 UBQLN4 UBTD1 USP5 USP7 VASP VPS37C WASF2 WBP1 WBP2 WDR5 WIPF1 ZNF688	98 interacting genes: ACVR1 ARID3A ARIH2 ARK2C ARRDC3 ASXL2 ATXN1 BARD1 BRCA1 CADPS2 CBL CHFR CHUK CNOT4 CUEDC1 CUL1 CUL3 CUL4A DAZAP2 DTX3 DTX3L DZIP3 HERC4 HMGB1 HTT IPO11 IRAK1 ITCH KLHL42 LAG3 MARCHF5 MDM2 MID1 MID2 MKRN3 MUL1 NEDD4L NFKBIA PGPEP1 PICK1 PJA1 PRKN RANGAP1 RBX1 RC3H2 RCBTB1 RFWD3 RING1 RMND5B RNF11 RNF111 RNF114 RNF115 RNF126 RNF13 RNF130 RNF14 RNF150 RNF166 RNF167 RNF181 RNF185 RNF2 RNF31 RNF4 RNF43 RNF5 RNF8 SAE1 SIAH1 SPOP STUB1 TGFBR1 TRIM2 TRIM27 TRIM32 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 TRIM54 TRIM55 TRIM62 TRIM63 TTC3 UBA1 UBA6 UBC UBOX5 UFM1 WBP2 WWP2 ZNF746 ZNF804A ZNRF1 ZNRF2 ZNRF4
Entrez ID		11060	10477
HPRD ID		03812	05000
Ensembl ID		ENSG00000198373	ENSG00000170035
Uniprot IDs		B4DHF6 O00308	Q969T4
PDB IDs		4Y07 5TJ7 5TJ8 5TJQ 6J1Z 6RSS 8EI5 8EI6 8EI7 8EI8 9EQH
Enriched GO Terms of Interacting Partners?		Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Proteolysis WW Domain Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Macromolecule Catabolic Process Ubiquitin Binding Protein Polyubiquitination Protein Modification By Small Protein Conjugation Endosome Catabolic Process Nucleoplasm Protein Ubiquitination Cytosol Post-translational Protein Modification Protein K48-linked Ubiquitination Multivesicular Body Assembly Multivesicular Body Organization Protein Metabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Binding Sensory Perception Of Salty Taste Regulation Of Proteasomal Protein Catabolic Process Endosome Organization Macroautophagy Regulation Of Proteolysis Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Metabolic Process Proteasomal Protein Catabolic Process Protein Catabolic Process Perinuclear Region Of Cytoplasm Proteasome Binding Autophagy Protein K11-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Ubiquitin-protein Transferase Activity Cellular Response To Aldosterone Sodium Channel Complex Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process	Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Protein Polyubiquitination Protein Modification Process Ubiquitin-protein Transferase Activity Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Transferase Activity Proteolysis Involved In Protein Catabolic Process Protein Metabolic Process Macromolecule Catabolic Process Zinc Ion Binding Proteolysis Protein Autoubiquitination Macromolecule Metabolic Process Catabolic Process Protein K48-linked Ubiquitination Metal Ion Binding Cytoplasm Protein K63-linked Ubiquitination Protein Catabolic Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Protein Monoubiquitination Response To Stress Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Signal Transduction Ubiquitin Ligase Complex Positive Regulation Of Catabolic Process Protein Destabilization Protein K6-linked Ubiquitination Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Innate Immune Response Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Autophagy Defense Response To Symbiont Positive Regulation Of Metabolic Process Cellular Response To Stress Defense Response To Other Organism
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