ADA and WFDC12

		ADA	WFDC12
Description		adenosine deaminase	WAP four-disulfide core domain 12
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Cytoplasmic Vesicle Cytoplasmic Vesicle Lumen Anchoring Junction	Extracellular Region Extracellular Space
	Molecular Function	Adenosine Deaminase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Deaminase Activity Metal Ion Binding 2'-deoxyadenosine Deaminase Activity	Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity
	Biological Process	Allantoin Metabolic Process Response To Hypoxia In Utero Embryonic Development Trophectodermal Cell Differentiation Liver Development Placenta Development Germinal Center B Cell Differentiation Germinal Center Formation Positive Regulation Of Germinal Center Formation Negative Regulation Of Leukocyte Migration Mature B Cell Apoptotic Process Negative Regulation Of Mature B Cell Apoptotic Process Adenosine Catabolic Process Deoxyadenosine Catabolic Process AMP Catabolic Process Xenobiotic Metabolic Process Apoptotic Process Smooth Muscle Contraction Cell Adhesion Nucleotide Metabolic Process Purine Ribonucleoside Monophosphate Biosynthetic Process Positive Regulation Of Heart Rate Response To Purine-containing Compound Calcium-mediated Signaling T Cell Differentiation Lung Development Positive Regulation Of B Cell Proliferation Purine Nucleotide Salvage GMP Salvage T Cell Differentiation In Thymus Positive Regulation Of T Cell Differentiation In Thymus Regulation Of Cell-cell Adhesion Mediated By Integrin B Cell Proliferation T Cell Activation Negative Regulation Of Apoptotic Process Penile Erection Purine-containing Compound Salvage Hypoxanthine Salvage Amide Catabolic Process AMP Salvage Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of T Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Smooth Muscle Contraction DAMP Catabolic Process DATP Catabolic Process Adenosine Metabolic Process Hypoxanthine Biosynthetic Process Inosine Biosynthetic Process Xanthine Biosynthetic Process Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Lung Alveolus Development Peyer's Patch Development Embryonic Digestive Tract Development Negative Regulation Of Inflammatory Response Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Leukocyte Migration Negative Regulation Of Adenosine Receptor Signaling Pathway Negative Regulation Of Penile Erection Thymocyte Apoptotic Process Negative Regulation Of Thymocyte Apoptotic Process Mucus Secretion Negative Regulation Of Mucus Secretion	Antibacterial Humoral Response Defense Response To Bacterium Innate Immune Response
Pathways		Purine salvage Defective ADA disrupts (deoxy)adenosine deamination Ribavirin ADME
Drugs		Pentostatin Dipyridamole FR221647 7,8-dihydroinosine FR117016 FR236913 6-hydroxy-1,6-dihydro purine nucleoside FR-234938 FR239087 FR230513 1-Deaza-Adenosine Nebularine (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol 1-((1R)-1-(HYDROXYMETHYL)-3-{6-[(3-PHENYLPROPANOYL)AMINO]-1H-INDOL-1-YL}PROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE 1-{(1R,2S)-2-HYDROXY-1-[2-(2-NAPHTHYLOXY)ETHYL]PROPYL}-1H-IMIDAZONE-4-CARBOXAMIDE 1-((1R,2S)-1-{2-[2-(4-CHLOROPHENYL)-1,3-BENZOXAZOL-7-YL]ETHYL}-2-HYDROXYPROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE
Diseases		T-B-Severe combined immunodeficiencies (SCIDs), including the following four diseases: Adenosine deaminase (ADA) deficiency; Recombinase activating gene (RAG) deficiencies; Artemis deficiency; Reticular dysgenesis
GWAS		Inflammatory bowel disease ( 28067908) Serum metabolite levels ( 33031748) Ulcerative colitis ( 23128233 28067908)	Bipolar disorder ( 31043756 34002096)
Interacting Genes		12 interacting genes: ADORA1 ADORA2A ADORA2B DPP4 DRD1 GRB2 NR3C1 PIAS2 SGCD TERF2IP TINF2 WFDC12	12 interacting genes: ADA ASPH MMP9 NNAT RBPJL SGTA SGTB SLC39A7 SULF2 TP53TG5 UBQLN1 UBQLN2
Entrez ID		100	128488
HPRD ID		00038	15674
Ensembl ID		ENSG00000196839	ENSG00000168703
Uniprot IDs		A0A0S2Z381 F5GWI4 P00813	Q8WWY7
PDB IDs		3IAR 7RTG
Enriched GO Terms of Interacting Partners?		G Protein-coupled Adenosine Receptor Activity G Protein-coupled Adenosine Receptor Signaling Pathway Vasodilation Purinergic Nucleotide Receptor Signaling Pathway Circulatory System Process Blood Vessel Diameter Maintenance Regulation Of Tube Size Presynaptic Modulation Of Chemical Synaptic Transmission Synaptic Transmission, Glutamatergic Shelterin Complex Heterotrimeric G-protein Binding Defense Response Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Synaptic Transmission, Glutamatergic Nuclear Telomere Cap Complex Regulation Of Amine Transport Vascular Process In Circulatory System Protein Localization To Chromosome, Telomeric Region Response To Stress Telomere Capping Asymmetric Synapse Axolemma Maternal Behavior Prepulse Inhibition Synaptic Transmission, Dopaminergic Parental Behavior Long-term Synaptic Depression Regulation Of Glutamate Secretion Regulation Of Circadian Sleep/wake Cycle, Sleep G Protein-coupled Receptor Activity Presynaptic Membrane Regulation Of Circadian Sleep/wake Cycle Positive Regulation Of Synaptic Transmission Regulation Of Intracellular Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Motor Behavior Telomeric DNA Binding Endocytosis Response To Amphetamine Positive Regulation Of Synaptic Transmission, Glutamatergic Reproductive Behavior Positive Regulation Of Potassium Ion Transport Regulation Of Synaptic Transmission, GABAergic Temperature Homeostasis Modulation Of Chemical Synaptic Transmission Locomotory Behavior Behavioral Fear Response Behavioral Defense Response Negative Regulation Of Synaptic Transmission Negative Regulation Of Telomere Maintenance	TRC Complex Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Proteolysis Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Transport Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Muscle Contraction Regulation Of Transport Regulation Of Proteasomal Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Protein Catabolic Process Smooth Muscle Contraction Mature B Cell Apoptotic Process Negative Regulation Of Adenosine Receptor Signaling Pathway Muscle System Process 2'-deoxyadenosine Deaminase Activity Xanthine Biosynthetic Process Negative Regulation Of Penile Erection Regulation Of Monoatomic Cation Transmembrane Transport Response To Endoplasmic Reticulum Stress Negative Regulation Of Store-operated Calcium Channel Activity Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Germinal Center Formation Negative Regulation Of Mucus Secretion Mononuclear Cell Differentiation Inosine Biosynthetic Process Penile Erection Hypoxanthine Salvage DATP Catabolic Process Peptidyl-aspartic Acid 3-dioxygenase Activity Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Protein Targeting To Membrane Negative Regulation Of G Protein-coupled Receptor Internalization Esophagus Smooth Muscle Contraction Autophagosome Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Negative Regulation Of Mature B Cell Apoptotic Process B Cell Differentiation DATP Metabolic Process
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