WFDC12 and SULF2

		WFDC12	SULF2
Description		WAP four-disulfide core domain 12	sulfatase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space Endoplasmic Reticulum Golgi Apparatus Golgi Stack Plasma Membrane Cell Surface
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity	Arylsulfatase Activity Calcium Ion Binding Protein Binding Glycosaminoglycan Binding N-acetylglucosamine-6-sulfatase Activity Sulfuric Ester Hydrolase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Antibacterial Humoral Response Defense Response To Bacterium Innate Immune Response	Kidney Development Chondrocyte Development Glomerular Filtration Response To Wounding Positive Regulation Of Vascular Endothelial Growth Factor Production Esophagus Smooth Muscle Contraction Positive Regulation Of Wnt Signaling Pathway Heparan Sulfate Proteoglycan Metabolic Process Glomerular Basement Membrane Development Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Embryonic Skeletal System Development Cartilage Development Bone Development Innervation Positive Regulation Of Canonical Wnt Signaling Pathway Liver Regeneration Positive Regulation Of Endothelin Production Regulation Of Hepatocyte Proliferation
Pathways
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756 34002096)	Academic attainment (English) ( 33594131) Apolipoprotein A1 levels ( 32203549) Attention deficit hyperactivity disorder (time to onset) ( 18937294) Cerebrospinal fluid AB1-42 levels ( 28247064) Depressive symptoms x herpes simplex 1 infection interaction ( 32564518) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) L-selectin levels ( 25576479) LDL levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429) Nephrotic syndrome (acquired) ( 21441931) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245)
Interacting Genes		12 interacting genes: ADA ASPH MMP9 NNAT RBPJL SGTA SGTB SLC39A7 SULF2 TP53TG5 UBQLN1 UBQLN2	1 interacting genes: WFDC12
Entrez ID		128488	55959
HPRD ID		15674	18130
Ensembl ID		ENSG00000168703	ENSG00000196562
Uniprot IDs		Q8WWY7	Q8IWU5
PDB IDs
Enriched GO Terms of Interacting Partners?		TRC Complex Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Proteolysis Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Transport Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Muscle Contraction Regulation Of Transport Regulation Of Proteasomal Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Protein Catabolic Process Smooth Muscle Contraction Mature B Cell Apoptotic Process Negative Regulation Of Adenosine Receptor Signaling Pathway Muscle System Process 2'-deoxyadenosine Deaminase Activity Xanthine Biosynthetic Process Negative Regulation Of Penile Erection Regulation Of Monoatomic Cation Transmembrane Transport Response To Endoplasmic Reticulum Stress Negative Regulation Of Store-operated Calcium Channel Activity Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Germinal Center Formation Negative Regulation Of Mucus Secretion Mononuclear Cell Differentiation Inosine Biosynthetic Process Penile Erection Hypoxanthine Salvage DATP Catabolic Process Peptidyl-aspartic Acid 3-dioxygenase Activity Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Protein Targeting To Membrane Negative Regulation Of G Protein-coupled Receptor Internalization Esophagus Smooth Muscle Contraction Autophagosome Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Negative Regulation Of Mature B Cell Apoptotic Process B Cell Differentiation DATP Metabolic Process
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