ADA and TERF2IP

Number of citations of the paper that reports this interaction (PubMedID 21044950)
82

Data Source:
BioGRID (two hybrid)

		ADA	TERF2IP
Description		adenosine deaminase	TERF2 interacting protein
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GO Annotations	Cellular Component	Cytoplasm Lysosome Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Cytoplasmic Vesicle Cytoplasmic Vesicle Lumen Anchoring Junction	Nuclear Chromosome Chromosome, Telomeric Region Nuclear Telomere Cap Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Cytoplasm Nuclear Body Shelterin Complex
	Molecular Function	Adenosine Deaminase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Deaminase Activity Metal Ion Binding 2'-deoxyadenosine Deaminase Activity	Protein Binding Phosphatase Binding Telomeric DNA Binding G-rich Strand Telomeric DNA Binding
	Biological Process	Allantoin Metabolic Process Response To Hypoxia In Utero Embryonic Development Trophectodermal Cell Differentiation Liver Development Placenta Development Germinal Center B Cell Differentiation Germinal Center Formation Positive Regulation Of Germinal Center Formation Negative Regulation Of Leukocyte Migration Mature B Cell Apoptotic Process Negative Regulation Of Mature B Cell Apoptotic Process Adenosine Catabolic Process Deoxyadenosine Catabolic Process AMP Catabolic Process Xenobiotic Metabolic Process Apoptotic Process Smooth Muscle Contraction Cell Adhesion Nucleotide Metabolic Process Purine Ribonucleoside Monophosphate Biosynthetic Process Positive Regulation Of Heart Rate Response To Purine-containing Compound Calcium-mediated Signaling T Cell Differentiation Lung Development Positive Regulation Of B Cell Proliferation Purine Nucleotide Salvage GMP Salvage T Cell Differentiation In Thymus Positive Regulation Of T Cell Differentiation In Thymus Regulation Of Cell-cell Adhesion Mediated By Integrin B Cell Proliferation T Cell Activation Negative Regulation Of Apoptotic Process Penile Erection Purine-containing Compound Salvage Hypoxanthine Salvage Amide Catabolic Process AMP Salvage Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of T Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Smooth Muscle Contraction DAMP Catabolic Process DATP Catabolic Process Adenosine Metabolic Process Hypoxanthine Biosynthetic Process Inosine Biosynthetic Process Xanthine Biosynthetic Process Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Lung Alveolus Development Peyer's Patch Development Embryonic Digestive Tract Development Negative Regulation Of Inflammatory Response Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Leukocyte Migration Negative Regulation Of Adenosine Receptor Signaling Pathway Negative Regulation Of Penile Erection Thymocyte Apoptotic Process Negative Regulation Of Thymocyte Apoptotic Process Mucus Secretion Negative Regulation Of Mucus Secretion	Telomere Maintenance Negative Regulation Of Protein Phosphorylation Regulation Of DNA-templated Transcription Telomere Maintenance Via Telomerase Regulation Of Double-strand Break Repair Via Homologous Recombination Telomere Maintenance Via Telomere Lengthening Telomere Capping Protection From Non-homologous End Joining At Telomere Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Intracellular Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of DNA Recombination At Telomere Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		Purine salvage Defective ADA disrupts (deoxy)adenosine deamination Ribavirin ADME	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere
Drugs		Pentostatin Dipyridamole FR221647 7,8-dihydroinosine FR117016 FR236913 6-hydroxy-1,6-dihydro purine nucleoside FR-234938 FR239087 FR230513 1-Deaza-Adenosine Nebularine (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol 1-((1R)-1-(HYDROXYMETHYL)-3-{6-[(3-PHENYLPROPANOYL)AMINO]-1H-INDOL-1-YL}PROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE 1-{(1R,2S)-2-HYDROXY-1-[2-(2-NAPHTHYLOXY)ETHYL]PROPYL}-1H-IMIDAZONE-4-CARBOXAMIDE 1-((1R,2S)-1-{2-[2-(4-CHLOROPHENYL)-1,3-BENZOXAZOL-7-YL]ETHYL}-2-HYDROXYPROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE
Diseases		T-B-Severe combined immunodeficiencies (SCIDs), including the following four diseases: Adenosine deaminase (ADA) deficiency; Recombinase activating gene (RAG) deficiencies; Artemis deficiency; Reticular dysgenesis
GWAS		Inflammatory bowel disease ( 28067908) Serum metabolite levels ( 33031748) Ulcerative colitis ( 23128233 28067908)	Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Weight ( 34074324)
Interacting Genes		12 interacting genes: ADORA1 ADORA2A ADORA2B DPP4 DRD1 GRB2 NR3C1 PIAS2 SGCD TERF2IP TINF2 WFDC12	123 interacting genes: ADA AIMP2 AK1 AKR1A1 AKR1B10 AKR7A3 AKT1 ANXA5 ANXA8L1 AP2B1 APEX1 ARPP21 BABAM1 BANP BCL7B C1orf174 CALML3 CHMP2B COTL1 CPNE2 CPNE3 CRK CRYBB1 CRYGS CTBP1 DBNL DDX23 DDX24 DDX39A DNMT3A DPP3 ENAH EPAS1 EPS8L1 ETS2 FABP2 GAGE5 GAMT GNMT GPAA1 H1-1 H2AC16 H4C2 HAAO HAGH HDGFL3 HMGB1 HMGB3 HMGN3 HMGN4 HNRNPK IDO1 IL1RN LANCL2 LGALSL MAGOHB MCM2 MDH1 MPG MRTO4 MT1X MT3 NAIF1 NASP NOL3 NPSR1 NUDT14 NUDT18 NXNL1 OCM2 OGFR PABIR1 PACSIN2 PACSIN3 PAFAH1B3 PCNP PCP4 PEA15 PGLS PGM1 PIAS1 PML PNMT PPP1R2 PPP6R3 PRDX6 PRX PTEN PTMA RABIF RAD50 RASSF5 RBBP9 RECQL4 RGMA RIF1 RPAP1 RPP25 S100P SBDS SCLY SCRN2 SET SNCG SP100 TALDO1 TBC1D10A TBCA TERF2 TMSB10 TMSB4Y TOR1AIP1 TSSC4 TWF2 UCHL1 VGLL4 WDR5 WIPI2 XAGE2 XPO1 XRCC5 ZNF146 ZNF414
Entrez ID		100	54386
HPRD ID		00038	05452
Ensembl ID		ENSG00000196839	ENSG00000166848
Uniprot IDs		A0A0S2Z381 F5GWI4 P00813	Q9NYB0
PDB IDs		3IAR 7RTG	1FEX 3K6G 4RQI 7OZ0 8RD4
Enriched GO Terms of Interacting Partners?		G Protein-coupled Adenosine Receptor Activity G Protein-coupled Adenosine Receptor Signaling Pathway Vasodilation Purinergic Nucleotide Receptor Signaling Pathway Circulatory System Process Blood Vessel Diameter Maintenance Regulation Of Tube Size Presynaptic Modulation Of Chemical Synaptic Transmission Synaptic Transmission, Glutamatergic Shelterin Complex Heterotrimeric G-protein Binding Defense Response Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Synaptic Transmission, Glutamatergic Nuclear Telomere Cap Complex Regulation Of Amine Transport Vascular Process In Circulatory System Protein Localization To Chromosome, Telomeric Region Response To Stress Telomere Capping Asymmetric Synapse Axolemma Maternal Behavior Prepulse Inhibition Synaptic Transmission, Dopaminergic Parental Behavior Long-term Synaptic Depression Regulation Of Glutamate Secretion Regulation Of Circadian Sleep/wake Cycle, Sleep G Protein-coupled Receptor Activity Presynaptic Membrane Regulation Of Circadian Sleep/wake Cycle Positive Regulation Of Synaptic Transmission Regulation Of Intracellular Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Motor Behavior Telomeric DNA Binding Endocytosis Response To Amphetamine Positive Regulation Of Synaptic Transmission, Glutamatergic Reproductive Behavior Positive Regulation Of Potassium Ion Transport Regulation Of Synaptic Transmission, GABAergic Temperature Homeostasis Modulation Of Chemical Synaptic Transmission Locomotory Behavior Behavioral Fear Response Behavioral Defense Response Negative Regulation Of Synaptic Transmission Negative Regulation Of Telomere Maintenance	Cytoplasm Protein Binding Cytosol Double-stranded Telomeric DNA Binding Nucleobase-containing Compound Metabolic Process Chromatin Organization Chromosome, Telomeric Region Telomere Organization Chromatin Remodeling Protein Domain Specific Binding Nucleus Telomere Maintenance Nucleoplasm Energy Reserve Metabolic Process Chromosome Organization Glycogen Metabolic Process Alcohol Dehydrogenase (NADP+) Activity Cellular Detoxification Of Aldehyde Extracellular Exosome Telomere Maintenance In Response To DNA Damage Myelin Maintenance Negative Regulation Of T-circle Formation Polysaccharide Metabolic Process Nucleic Acid Metabolic Process Nicotinamide Nucleotide Metabolic Process Maintenance Of Protein Localization In Organelle DNA Metabolic Process Plasma Membrane Organization Quinolinate Biosynthetic Process Allyl-alcohol Dehydrogenase Activity DNA Recombination Helicase Activity Regulation Of Growth Generation Of Precursor Metabolites And Energy Calcium-dependent Phospholipid Binding Negative Regulation Of DNA Metabolic Process Cadherin Binding Regulation Of Cellular Response To Stress Quinolinate Metabolic Process Mre11 Complex Negative Regulation Of Cellular Component Organization Carbohydrate Metabolic Process Regulation Of Cell Growth Actin Monomer Binding Positive Regulation Of Proteolysis Maintenance Of Protein Location In Cell RNA-templated DNA Biosynthetic Process
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