WFDC12 and NNAT

		WFDC12	NNAT
Description		WAP four-disulfide core domain 12	neuronatin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytoplasm
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity
	Biological Process	Antibacterial Humoral Response Defense Response To Bacterium Innate Immune Response	Brain Development Protein Lipoylation Positive Regulation Of Insulin Secretion
Pathways
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756 34002096)
Interacting Genes		12 interacting genes: ADA ASPH MMP9 NNAT RBPJL SGTA SGTB SLC39A7 SULF2 TP53TG5 UBQLN1 UBQLN2	3 interacting genes: APP NHLRC1 WFDC12
Entrez ID		128488	4826
HPRD ID		15674	04377
Ensembl ID		ENSG00000168703	ENSG00000053438
Uniprot IDs		Q8WWY7	A0A3B3ITN5 Q16517
PDB IDs
Enriched GO Terms of Interacting Partners?		TRC Complex Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Proteolysis Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Transport Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Muscle Contraction Regulation Of Transport Regulation Of Proteasomal Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Protein Catabolic Process Smooth Muscle Contraction Mature B Cell Apoptotic Process Negative Regulation Of Adenosine Receptor Signaling Pathway Muscle System Process 2'-deoxyadenosine Deaminase Activity Xanthine Biosynthetic Process Negative Regulation Of Penile Erection Regulation Of Monoatomic Cation Transmembrane Transport Response To Endoplasmic Reticulum Stress Negative Regulation Of Store-operated Calcium Channel Activity Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Germinal Center Formation Negative Regulation Of Mucus Secretion Mononuclear Cell Differentiation Inosine Biosynthetic Process Penile Erection Hypoxanthine Salvage DATP Catabolic Process Peptidyl-aspartic Acid 3-dioxygenase Activity Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Protein Targeting To Membrane Negative Regulation Of G Protein-coupled Receptor Internalization Esophagus Smooth Muscle Contraction Autophagosome Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Negative Regulation Of Mature B Cell Apoptotic Process B Cell Differentiation DATP Metabolic Process	Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Antibacterial Humoral Response Positive Regulation Of Toll Signaling Pathway Peptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Antimicrobial Humoral Response Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Humoral Immune Response Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Defense Response To Bacterium Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Response To Bacterium Antifungal Humoral Response Nuclear Envelope Lumen Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding
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