TLK1 and UBE3C

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		TLK1	UBE3C
Description		tousled like kinase 1	ubiquitin protein ligase E3C
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Proteasome Complex Nucleus
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity	Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Chromatin Assembly Or Disassembly Chromatin Organization Protein Phosphorylation Intracellular Protein Transport Cellular Response To DNA Damage Stimulus Cell Cycle Chromosome Segregation Peptidyl-serine Phosphorylation Intracellular Signal Transduction	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Fostamatinib
Diseases
GWAS		Health literacy ( 31250787) Liver enzyme levels (alkaline phosphatase) ( 33972514) Menopause (age at onset) ( 22267201 26414677) Platelet distribution width ( 32888494 27863252)	Body mass index ( 25673413) Language impairment in frontotemporal lobe dementia ( 29724592) Quantitative traits ( 19197348) Response to citalopram treatment ( 19846067) Type 2 diabetes ( 30054458)
Interacting Genes		29 interacting genes: ASF1A ASF1B AURKA BEND7 BHLHB9 CHEK1 CXCR5 DPPA4 DYNLL2 H1-1 LHX2 LUZP4 MBP NBN PAX6 PINX1 PTPN11 RAD9A SNAP23 TFCP2 TLK2 TPM3 UBE3C YAF2 YWHAE ZNF655 ZNF773 ZNF829 ZSCAN22	12 interacting genes: APP CAND2 CCNB1 GOLGA2 MTA2 PSMC5 PSMD2 TLK1 UBE2D1 UBE2D2 UBE2D3 UBE2L3
Entrez ID		9874	9690
HPRD ID		12232	15604
Ensembl ID		ENSG00000198586	ENSG00000009335
Uniprot IDs		Q9UKI8	Q15386
PDB IDs			6K2C
Enriched GO Terms of Interacting Partners?
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