UBE3C and TLK1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		UBE3C	TLK1
Description		ubiquitin protein ligase E3C	tousled like kinase 1
Image			No pdb structure
GO Annotations	Cellular Component	Proteasome Complex Nucleus	Nucleus Nucleoplasm
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Activity	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process	Regulation Of Chromatin Assembly Or Disassembly Chromatin Organization Protein Phosphorylation Intracellular Protein Transport Cellular Response To DNA Damage Stimulus Cell Cycle Chromosome Segregation Peptidyl-serine Phosphorylation Intracellular Signal Transduction
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs			Fostamatinib
Diseases
GWAS		Body mass index ( 25673413) Language impairment in frontotemporal lobe dementia ( 29724592) Quantitative traits ( 19197348) Response to citalopram treatment ( 19846067) Type 2 diabetes ( 30054458)	Health literacy ( 31250787) Liver enzyme levels (alkaline phosphatase) ( 33972514) Menopause (age at onset) ( 22267201 26414677) Platelet distribution width ( 32888494 27863252)
Interacting Genes		12 interacting genes: APP CAND2 CCNB1 GOLGA2 MTA2 PSMC5 PSMD2 TLK1 UBE2D1 UBE2D2 UBE2D3 UBE2L3	29 interacting genes: ASF1A ASF1B AURKA BEND7 BHLHB9 CHEK1 CXCR5 DPPA4 DYNLL2 H1-1 LHX2 LUZP4 MBP NBN PAX6 PINX1 PTPN11 RAD9A SNAP23 TFCP2 TLK2 TPM3 UBE3C YAF2 YWHAE ZNF655 ZNF773 ZNF829 ZSCAN22
Entrez ID		9690	9874
HPRD ID		15604	12232
Ensembl ID		ENSG00000009335	ENSG00000198586
Uniprot IDs		Q15386	Q9UKI8
PDB IDs		6K2C
Enriched GO Terms of Interacting Partners?
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