TLK1 and PINX1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TLK1	PINX1
Description		tousled like kinase 1	PIN2 (TERF1) interacting telomerase inhibitor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nuclear Chromosome Kinetochore Chromosome, Telomeric Region Nucleoplasm Nucleolus Mitochondrion Spindle
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity	Protein Binding Telomerase Inhibitor Activity Protein-containing Complex Binding Telomerase RNA Binding
	Biological Process	Regulation Of Chromatin Assembly Or Disassembly Chromatin Organization Protein Phosphorylation Intracellular Protein Transport Cellular Response To DNA Damage Stimulus Cell Cycle Chromosome Segregation Peptidyl-serine Phosphorylation Intracellular Signal Transduction	Telomere Maintenance Via Telomerase Mitotic Metaphase Plate Congression Negative Regulation Of Cell Population Proliferation Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Negative Regulation Of Telomerase Activity Protein Localization To Chromosome, Telomeric Region Protein Localization To Nucleolus Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Telomeric DNA Binding Positive Regulation Of Protein Localization To Nucleolus
Pathways
Drugs		Fostamatinib
Diseases
GWAS		Health literacy ( 31250787) Liver enzyme levels (alkaline phosphatase) ( 33972514) Menopause (age at onset) ( 22267201 26414677) Platelet distribution width ( 32888494 27863252)	Adventurousness ( 30643258) Anxiety/tension (special factor of neuroticism) ( 30867560) Aspartate aminotransferase levels ( 33547301) Autism spectrum disorder ( 30804558) Body shape index ( 34021172) Brain morphology (MOSTest) ( 32665545) Carotid intima media thickness ( 30510157 21909108) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Gut microbiota (beta diversity) ( 27723756) Lymphocyte counts ( 32888494 27863252) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (calcium channel blockers) ( 31015401) Retinal vascular caliber ( 21060863) Serum alkaline phosphatase levels ( 33547301) Systemic lupus erythematosus ( 26316170) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglyceride levels ( 28334899 32154731) Triglycerides ( 24097068 30275531 20686565) Type 2 diabetes ( 30054458) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494 27863252)
Interacting Genes		29 interacting genes: ASF1A ASF1B AURKA BEND7 BHLHB9 CHEK1 CXCR5 DPPA4 DYNLL2 H1-1 LHX2 LUZP4 MBP NBN PAX6 PINX1 PTPN11 RAD9A SNAP23 TFCP2 TLK2 TPM3 UBE3C YAF2 YWHAE ZNF655 ZNF773 ZNF829 ZSCAN22	21 interacting genes: AIDA APP ARHGEF10 BNIP1 C14orf119 CACYBP DLGAP2 EIF1AD GABPA GYS1 MCRS1 MPZ PAFAH1B2 PTP4A3 RP1L1 TERF1 TERT TLK1 TNPO2 TP63 UBL5
Entrez ID		9874	54984
HPRD ID		12232	05934
Ensembl ID		ENSG00000198586	ENSG00000254093
Uniprot IDs		Q9UKI8	Q96BK5
PDB IDs
Enriched GO Terms of Interacting Partners?
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